Please use this identifier to cite or link to this item:
https://observatorio.fm.usp.br/handle/OPI/33208
Title: | The Immunomodulatory Potential of Wharton's Jelly Mesenchymal Stem/Stromal Cells |
Authors: | PALADINO, Fernanda Vieira; RODRIGUES, Juliana de Moraes; SILVA, Aline da; GOLDBERG, Anna Carla |
Citation: | STEM CELLS INTERNATIONAL, article ID 3548917, 7p, 2019 |
Abstract: | The benefits attributed to mesenchymal stem/stromal cells (MSC) in cell therapy applications are mainly attributed to the secretion of factors, which exhibit immunomodulatory and anti-inflammatory effects and stimulate angiogenesis. Despite the desirable features such as high proliferation levels, multipotency, and immune response regulation, there are important variables that must be considered. Although presenting similar morphological aspects, MSC collected from different tissues can form heterogeneous cellular populations and, therefore, manifest functional differences. Thus, the source of MSC should be a factor to be considered in the development of novel therapies. The following text presents an updated review of recent research outcomes related to Wharton's jelly mesenchymal stem/stromal cells (WJ-MSC), harvested from umbilical cords and considered novel and potential candidates for the development of cell-based approaches. This text highlights information on how WJ-MSC affect immune responses in comparison with other sources of MSC. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/Outros |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
art_PALADINO_The_Immunomodulatory_Potential_of_Whartons_Jelly_Mesenchymal_StemStromal_2019.PDF | publishedVersion (English) | 1.7 MB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.