The effect of frequency of activity interruptions in prolonged sitting on postprandial glucose metabolism: A randomized crossover trial

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art_THORSEN_The_effect_of_frequency_of_activity_interruptions_in_2019.PDF (516.56 KB)
Citações na Scopus
20
Tipo de produção
article
Data de publicação
2019
Editora
W B SAUNDERS CO-ELSEVIER INC
DOI
Indexadores
Scopus
Web of Science
PubMed
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ISSN da Revista
Título do Volume
Autores
THORSEN, Ida K.
JOHANSEN, Mette Y.
PILMARK, Nanna S.
JESPERSEN, Naja Z.
BRINKLOV, Cecilie F.
DUNSTAN, David W.
KARSTOFT, Kristian
PEDERSEN, Bente K.
RIED-LARSEN, Mathias
Autor de Grupo de pesquisa
Editores
Coordenadores
Organizadores
Citação
METABOLISM-CLINICAL AND EXPERIMENTAL, v.96, p.1-7, 2019
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Objective: The primary objective was to test the hypothesis that increased frequency of interruptions in prolonged sitting reduces postprandial glycemia independent of energy intake and expenditure. Materials/Methods: Healthy, sedentary, centrally obese men (n = 14; age*, 28.2 (23.4; 38.3) years; BMI, 31.9 +/- 6.7 kg/m 2 ; VO(2)max*, 39.5 (38.8; 40.9) ml/min/kg; HbA1c, 53 +/- 0.4% (34.1 +/- 42 mmol/mol); mean +/- SD (*median (25th; 75th percentile)) completed four 8-h interventions in randomized order: 1) uninterrupted sitting (SIT), 2) sitting interrupted by 2 min of walking (-30% of VO2max) every 20th minute (INT20), 3) sitting interrupted by 6 min of walking every hour (INT60), and 4) sitting interrupted by 12 min of walking every second hour (INT120). A standardized test drink was served at the beginning of and 4 h into the intervention (total of 2310 +/- 247 kcal; 50% energy from carbohydrate, 50% energy from fat). Outcomes induded the difference in the 8-h total area under the curve (tAUC) for primarily plasma glucose, and secondarily plasma insulin and C-peptide during INT20, INT60, and INT120 compared to SIT. Results: No difference [95% CI] was observed in the primary outcome, the 8-h tAUC for the plasma glucose, during INT20, INT60, and INT120 compared to SIT ( -65.3 mmol/I*min [ - 256.3 ; 125.7], +53.8 mmol/l*min [ - 143.1; 250.8], and +18.6 mmol/l*min [-172.4; 209.6], respectively). Conclusions: Interrupting sitting with increasing frequency did not reduce the postprandial plasma glucose response to prolonged sitting in healthy, sedentary, centrally obese men.
Palavras-chave
Sedentary behavior, Walking, Cardiometabolic risk, Postprandial glucose metabolism, Postprandial lipid metabolism, Substrate oxidation
URI
https://observatorio.fm.usp.br/handle/OPI/33232
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Coleções
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/17
Artigos e Materiais de Revistas Científicas - ODS/03