Pancreatic endosonographic findings and clinical correlation in Crohn's disease
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Citações na Scopus
4
Tipo de produção
article
Data de publicação
2019
Editora
HOSPITAL CLINICAS, UNIV SAO PAULO
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Título do Volume
Autores
MALLUTA, Everson Fernando
NISHITOKUKADO, Lecia
LORDELLO, Maria Laura Lacava
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Citação
CLINICS, v.74, article ID e853, 6p, 2019
Resumo
OBJECTIVES: We aimed to evaluate the incidence of pancreatic alterations in Crohn's disease using endoscopic ultrasound (EUS) and to correlate the number of alterations with current clinical data. METHODS: Patients diagnosed with Crohn's disease (n= 51) were examined using EUS, and 11 variables were analyzed. A control group consisted of patients with no history of pancreatic disease or Crohn's disease. Patients presenting with three or more alterations underwent magnetic resonance imaging (MRI). Pancreatic function was determined using a fecal elastase assay. RESULTS: Two of the 51 patients (3.9%) presented with four EUS alterations, 3 (5.9%) presented with three, 11 (21.5%) presented with two, and 13 (25.5%) presented with one; in the control group, only 16% presented with one EUS alteration (p< 0.001). Parenchymal abnormalities accounted for 39 of the EUS findings, and ductal abnormalities accounted for 11. Pancreatic lesions were not detected by MRI. Low fecal elastase levels were observed in 4 patients, none of whom presented with significant pancreatic alterations after undergoing EUS. Ileal involvement was predictive of the number of EUS alterations. CONCLUSION: A higher incidence of pancreatic abnormalities was found in patients with Crohn's disease than in individuals in the control group. The majority of these abnormalities are related to parenchymal alterations. In this group of patients, future studies should be conducted to determine whether such morphological abnormalities could evolve to induce exocrine or endocrine pancreatic insufficiency and, if so, identify the risk factors and determine which patients should undergo EUS.
Palavras-chave
Crohn's Disease, Pancreatitis, Pancreatic Exocrine Insufficiency, Endosonography, Cholangiopancreatography
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