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https://observatorio.fm.usp.br/handle/OPI/33260
Title: | Treatment of post-intubation laryngeal granulomas: systematic review and proportional meta-analysis |
Authors: | RIMOLI, Caroline Fernandes; MARTINSA, Regina Helena Garcia; CATANEO, Daniele Cristina; IMAMURA, Rui; CATANEO, Antonio Jose Maria |
Citation: | BRAZILIAN JOURNAL OF OTORHINOLARYNGOLOGY, v.84, n.6, p.781-789, 2018 |
Abstract: | Introduction: Laryngeal granulomas post intubation are benign but recurrent lesions. There is no consensus for its treatment. Objective: To describe the effectiveness of different treatment modalities for primary or recurrent laryngeal granulomas resulting from endotracheal intubation. Methods: Systematic review and proportional meta-analysis. Eligibility criteria-experimental or observational studies with at least five subjects. Outcomes studied-granuloma resolution, recurrence, and time for resolution. Databases used-Pubmed, Embase, Lilacs, and Cochrane. The Stats Direct 3.0.121 program was used. Results: Six studies were selected, with 85 patients. The treatments registered were: antireflux therapy, speech therapy, anti-inflammatory drugs, steroids, antibiotics, zinc sulfate and surgery. 85 patients from six studies had primary treatment: surgery +/- associations (41 patients), resolution chance 75% (95% CI: 0.3-100%, I-2 = 90%), absolute relapse risk 25% (95% CI: 0.2-71%); medical treatment (44 patients), resolution chance 86% (95% CI: 67-97%); and absolute relapse risk 14% (95% CI: 3-33%). There was no significant difference between groups. Three studies, encompassing 19 patients, analyzed secondary treatment (failure or recurrence after primary treatment); three subjects presented new recurrence. The time needed to resolve the lesions varied from immediate, after surgery, to 23 months, for inhaled steroid. Conclusion: There is no evidence of high quality that proves the efficacy of any treatment for laryngeal granulomas resulting from endotracheal intubation. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - LIM/32 |
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