Hepatitis C virus infection status and associated factors among a multi-site sample of people who used illicit drugs in the Amazon region

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.author OLIVEIRA-FILHO, Aldemir B.
SANTOS, Francisco Junior A.
SILVA, Fabricio Quaresma
RAIOL, Nairis Costa
COSTA, Camila Carla S.
PIAUIENSE, Juliana Nadia F.
MARTINS, Luisa Caricio
CARDOSO, Yasmin Maria N.
MICELI, Jeruza Ferraz F. Di
RESQUE, Rafael Lima
SILVA-OLIVEIRA, Glaucia C.
PINHEIRO, Luiz Marcelo L.
MACHADO, Luiz Fernando A.
PINHO, Joao Renato R. FMUSP-HC
LEMOS, Jose Alexandre R.
KUPEK, Emil
FISCHER, Benedikt
dc.date.issued 2019
dc.identifier.citation BMC INFECTIOUS DISEASES, v.19, article ID 634, 10p, 2019
dc.identifier.issn 1471-2334
dc.identifier.uri http://observatorio.fm.usp.br/handle/OPI/33266
dc.description.abstract BackgroundElevated rates of Hepatitis C Virus (HCV) infection have been reported in epidemiological studies with people who used illicit drugs (PWUIDs) in different Brazilian regions. In Brazil's Amazon region, studies have already identified the common use of illicit drugs among adolescents and the high prevalence of HCV infections among PWUIDs. However, all studies done with PWUIDs were conducted with small samples and within limited geographic coverage. This study determined the prevalence and risk factors for HCV infection in PWUIDs in the Amazon region, northern Brazil, as well as estimating the prevalence and factors associated with the HCV spontaneous clearance (HSC).MethodsThis cross-sectional study accessed 1666 PWUIDs from multiple municipalities of the Amazon region. Socio-demographic, economic, drug use and health-related information were collected through interviews. Blood samples collected were tested for the presence of anti-HCV antibodies and RNA-HCV. HCV genotypes were identified by real-time polymerase chain reaction (PCR). Logistic regressions were run to identify factors independently associated with HCV infection status and HSC.ResultsIn total, 577 (34.6%) featured HCV antibodies, of which 384 (23.1%) had active HCV infection and 193 (11.6%) indicated HSC. Genotypes 1 (80.2%) and 3 (18.8%) were detected. HCV infection status was associated with the length of illicit drug use history, factors related to parenteral and sexual transmission, and factors of socio-economic marginalization leading to potential risk activities for HCV. HSC was associated with the ethnic (including indigenous) background of participants.ConclusionsHigh levels of HCV infection were detected in PWUIDs. Genotype 1 was predominant. Intense use of illicit drugs, unprotected sexual intercourse, high number of sexual partners and social marginalization were associated with all HCV infection. HSC was associated with origin (Amazonian-born) and non-white (e.g., Black or Indigenous) of PWUIDs. These findings emphasize the need for improve HCV prevention and control services and care for PWUIDs in the Brazilian Amazon region.
dc.description.sponsorship · Ministerio da Saude/Secretaria de Vigilancia em Saude (MS/SVS)
· Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ)
· CNPQ fellowships
· Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) fellowships
dc.language.iso eng
dc.publisher BMC
dc.relation.ispartof BMC Infectious Diseases
dc.rights openAccess
dc.subject HCV; Epidemiology; Spontaneous clearance; People who used illicit drugs; Brazil; Amazon
dc.subject.other hcv infection; global epidemiology; inject drugs; cocaine users; prevalence; transmission; genotypes; crack; risk; hiv
dc.title Hepatitis C virus infection status and associated factors among a multi-site sample of people who used illicit drugs in the Amazon region
dc.type article
dc.rights.holder Copyright BMC
dc.description.group LIM/03
dc.identifier.doi 10.1186/s12879-019-4270-2
dc.identifier.pmid 31315569
dc.type.category original article
dc.type.version publishedVersion
hcfmusp.author PINHO, Joao Renato R.:HC:ICHC
hcfmusp.author.external · OLIVEIRA-FILHO, Aldemir B.:Univ Fed Para, Lab Celulas & Patogenos, Grp Estudo & Pesquisa Populacoes Vulneraveis GEPP, Inst Estudos Costeiros, Campus Braganca,Alameda Leandro Ribeiro S-N, Braganca, PA, Brazil
· SANTOS, Francisco Junior A.:Univ Fed Para, Lab Celulas & Patogenos, Grp Estudo & Pesquisa Populacoes Vulneraveis GEPP, Inst Estudos Costeiros, Campus Braganca,Alameda Leandro Ribeiro S-N, Braganca, PA, Brazil
· SILVA, Fabricio Quaresma:Univ Fed Para, Lab Celulas & Patogenos, Grp Estudo & Pesquisa Populacoes Vulneraveis GEPP, Inst Estudos Costeiros, Campus Braganca,Alameda Leandro Ribeiro S-N, Braganca, PA, Brazil
· RAIOL, Nairis Costa:Univ Fed Para, Lab Celulas & Patogenos, Grp Estudo & Pesquisa Populacoes Vulneraveis GEPP, Inst Estudos Costeiros, Campus Braganca,Alameda Leandro Ribeiro S-N, Braganca, PA, Brazil
· COSTA, Camila Carla S.:Univ Fed Para, Lab Celulas & Patogenos, Grp Estudo & Pesquisa Populacoes Vulneraveis GEPP, Inst Estudos Costeiros, Campus Braganca,Alameda Leandro Ribeiro S-N, Braganca, PA, Brazil; Univ Fed Para, Lab Patol Clin Doencas Tropicais, Nucleo Med Trop, Belem, Para, Brazil
· PIAUIENSE, Juliana Nadia F.:Univ Fed Para, Lab Celulas & Patogenos, Grp Estudo & Pesquisa Populacoes Vulneraveis GEPP, Inst Estudos Costeiros, Campus Braganca,Alameda Leandro Ribeiro S-N, Braganca, PA, Brazil; Univ Fed Para, Lab Patol Clin Doencas Tropicais, Nucleo Med Trop, Belem, Para, Brazil
· MARTINS, Luisa Caricio:Univ Fed Para, Lab Patol Clin Doencas Tropicais, Nucleo Med Trop, Belem, Para, Brazil
· CARDOSO, Yasmin Maria N.:Univ Fed Amapa, Lab Toxicol & Quim Farmaceut, Ctr Ciencias Biol & Saude, Macapa, AP, Brazil
· MICELI, Jeruza Ferraz F. Di:Univ Fed Amapa, Lab Toxicol & Quim Farmaceut, Ctr Ciencias Biol & Saude, Macapa, AP, Brazil
· RESQUE, Rafael Lima:Univ Fed Amapa, Lab Toxicol & Quim Farmaceut, Ctr Ciencias Biol & Saude, Macapa, AP, Brazil
· SILVA-OLIVEIRA, Glaucia C.:Univ Fed Para, Lab Celulas & Patogenos, Grp Estudo & Pesquisa Populacoes Vulneraveis GEPP, Inst Estudos Costeiros, Campus Braganca,Alameda Leandro Ribeiro S-N, Braganca, PA, Brazil
· PINHEIRO, Luiz Marcelo L.:Univ Fed Para, Fac Ciencias Biol, Campus Marajo Soure, Soure, PA, Brazil
· MACHADO, Luiz Fernando A.:Univ Fed Para, Lab Virol, Inst Ciencias Biol, Belem, PA, Brazil
· LEMOS, Jose Alexandre R.:Univ Fed Para, Programa Posgrad Profiss Anal Clin, Inst Ciencias Biol, Belem, PA, Brazil
· KUPEK, Emil:Univ Fed Santa Catarina, Dept Saude Publ, Florianopolis, SC, Brazil
· FISCHER, Benedikt:CAMH, Inst Mental Hlth Policy Res, Toronto, ON, Canada; Univ Toronto, Dept Psychiat, Toronto, ON, Canada; Univ Auckland, Fac Med & Hlth Sci, Grafton, AK, New Zealand
hcfmusp.origem.id WOS:000475922100006
hcfmusp.origem.id 2-s2.0-85069456855
hcfmusp.publisher.city LONDON
hcfmusp.publisher.country ENGLAND
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dc.description.index MEDLINE
hcfmusp.citation.wos 0
hcfmusp.affiliation.country Brasil
hcfmusp.affiliation.country Nova Zelândia


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