Risk factors for loss of residual renal function in children treated with chronic peritoneal dialysis
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Citações na Scopus
35
Tipo de produção
article
Data de publicação
2015
Editora
ELSEVIER SCIENCE INC
Indexadores
Título da Revista
ISSN da Revista
Título do Volume
Autores
HA, Il-Soo
YAP, Hui K.
MUNARRIZ, Reyner L.
ZAMBRANO, Pedro H.
FLYNN, Joseph T.
BILGE, Ilmay
SZCZEPANSKA, Maria
LAI, Wai-Ming
ANTONIO, Zenaida L.
GULATI, Ashima
Autor de Grupo de pesquisa
Int Pediatric Peritoneal Dialysis
Editores
Coordenadores
Organizadores
Citação
KIDNEY INTERNATIONAL, v.88, n.3, p.605-613, 2015
Resumo
In dialyzed patients, preservation of residual renal function is associated with better survival, lower morbidity, and greater quality of life. To analyze the evolution of residual diuresis over time, we prospectively monitored urine output in 401 pediatric patients in the global IPPN registry who commenced peritoneal dialysis (PD) with significant residual renal function. Associations of patient characteristics and time-variant covariates with daily urine output and the risk of developing oligoanuria (under 100 ml/m(2)/day) were analyzed by mixed linear modeling and Cox regression analysis including time-varying covariates. With an average loss of daily urine volume of 130 ml/m(2) per year, median time to oligoanuria was 48 months. Residual diuresis significantly subsided more rapidly in children with glomerulopathies, lower diuresis at start of PD, high ultrafiltration volume, and icodextrin use. Administration of diuretics significantly reduced oligoanuria risk, whereas the prescription of renin-angiotensin system antagonists significantly increased the risk oligoanuria. Urine output on PD was significantly associated in a negative manner with glomerulopathies (-584 ml/m(2)) and marginally with the use of icodextrin (-179 ml/m(2)) but positively associated with the use of biocompatible PD fluid (+111 ml/m(2)). Children in both Asia and North America had consistently lower urine output compared with those in Europe perhaps due to regional variances in therapy. Thus, in children undergoing PD, residual renal function depends strongly on the cause of underlying kidney disease and may be modifiable by diuretic therapy, peritoneal ultrafiltration, and choice of PD fluid.
Palavras-chave
children, oligoanuria, peritoneal dialysis, registry, risk factors, urine volume
Referências
- Bakkaloglu SA, 2009, NEPHROL DIAL TRANSPL, V24, P3525, DOI 10.1093/ndt/gfp297
- Bernardo Ana, 2009, Adv Perit Dial, V25, P110
- Borzych-Duzalka D, 2013, J AM SOC NEPHROL, V24, P665, DOI 10.1681/ASN.2012050433
- Bragg-Gresham JL, 2007, AM J KIDNEY DIS, V49, P426, DOI 10.1053/j.ajkd.2006.12.012
- Caravaca F, 2002, PERITON DIALYSIS INT, V22, P414
- Chadha V, 2001, PERITON DIALYSIS INT, V21, pS179
- Cho Y, 2014, COCHRANE DB SYST REV, V3
- Cho Y, 2013, KIDNEY INT, V84, P969, DOI 10.1038/ki.2013.190
- Coronel F, 2007, PERITON DIALYSIS INT, V27, P454
- Drechsler C, 2009, AM J KIDNEY DIS, V53, P1014, DOI 10.1053/j.ajkd.2008.11.027
- Fan SLS, 2008, KIDNEY INT, V73, P200, DOI 10.1038/sj.ki.5002574
- FEBER J, 1994, PEDIATR NEPHROL, V8, P579, DOI 10.1007/BF00858132
- Guzzo I, 2009, PEDIATR NEPHROL, V24, P1391, DOI 10.1007/s00467-009-1144-7
- Haag-Weber M, 2010, NEPHROL DIAL TRANSPL, V25, P2288, DOI 10.1093/ndt/gfq087
- Harambat J, 2013, AM J TRANSPLANT, V13, P2066, DOI 10.1111/ajt.12288
- Herget-Rosenthal S, 2012, KIDNEY BLOOD PRESS R, V35, P233, DOI 10.1159/000332887
- Hidaka H, 2003, NEPHROLOGY, V8, P184, DOI 10.1046/j.1440-1797.2003.00156.x
- Hiroshige K, 1996, PERITON DIALYSIS INT, V16, P307
- Hufnagel C, 1999, NEPHROL DIAL TRANSPL, V14, P1224, DOI 10.1093/ndt/14.5.1224
- Jafar TH, 2003, ANN INTERN MED, V139, P244, DOI 10.7326/0003-4819-139-4-200308190-00006
- Johnson DW, 2012, J AM SOC NEPHROL, V23, P1097, DOI 10.1681/ASN.2011121201
- Johnson DW, 2003, PERITON DIALYSIS INT, V23, P276
- Kim S, 2009, NEPHROL DIAL TRANSPL, V24, P2899, DOI 10.1093/ndt/gfp054
- Lang SM, 2001, PERITON DIALYSIS INT, V21, P52
- Liao CT, 2008, PERITON DIALYSIS INT, V28, pS191
- Liao CT, 2009, NEPHROL DIAL TRANSPL, V24, P2909, DOI 10.1093/ndt/gfp056
- Lui SL, 2012, AM J KIDNEY DIS, V60, P966, DOI 10.1053/j.ajkd.2012.05.018
- Lysaght M J, 1991, ASAIO Trans, V37, P598
- Marron B, 2008, KIDNEY INT, V73, pS42, DOI 10.1038/sj.ki.5002600
- Medcalf JF, 2001, KIDNEY INT, V59, P1128, DOI 10.1046/j.1523-1755.2001.00598.x
- Michels WM, 2011, CLIN J AM SOC NEPHRO, V6, P537, DOI 10.2215/CJN.00470110
- Misra M, 2001, KIDNEY INT, V59, P754, DOI 10.1046/j.1523-1755.2001.059002754.x
- Moist LM, 2000, J AM SOC NEPHROL, V11, P556
- Natl High Blood Pressure Educ Prog, 2004, PEDIATRICS, V114, P555
- Perl J, 2009, AM J KIDNEY DIS, V53, P1068, DOI 10.1053/j.ajkd.2009.02.012
- Shemin D, 2000, PERITON DIALYSIS INT, V20, P439
- Shin SK, 1999, PERITON DIALYSIS INT, V19, P138
- Singhal MK, 2000, PERITON DIALYSIS INT, V20, P429
- Takatori Y, 2011, CLIN J AM SOC NEPHRO, V6, P1337, DOI 10.2215/CJN.10041110
- VANOLDEN RW, 1992, AM J NEPHROL, V12, P351, DOI 10.1159/000168471
- Wang AYM, 2006, KIDNEY INT, V69, P1726, DOI 10.1038/sj.ki.5000382
- Wuhl E, 2009, NEW ENGL J MED, V361, P1639, DOI 10.1056/NEJMoa0902066