Please use this identifier to cite or link to this item:
https://observatorio.fm.usp.br/handle/OPI/33433
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | |
dc.contributor.author | SOUSA, L. F. A. de | |
dc.contributor.author | PAUPITZ, J. A. | |
dc.contributor.author | AIKAWA, N. E. | |
dc.contributor.author | TAKAYAMA, L. | |
dc.contributor.author | CAPARBO, V. F. | |
dc.contributor.author | PEREIRA, R. M. R. | |
dc.date.accessioned | 2019-09-23T14:15:41Z | - |
dc.date.available | 2019-09-23T14:15:41Z | - |
dc.date.issued | 2019 | |
dc.identifier.citation | LUPUS, v.28, n.10, p.1224-1232, 2019 | |
dc.identifier.issn | 0961-2033 | |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/33433 | - |
dc.description.abstract | Objective Juvenile-onset systemic lupus erythematosus (JoSLE) is associated with low bone mass for age and fractures; nevertheless, risk factors for bone impairment are poorly understood. The aim of this study was to evaluate risk factors for bone mass loss in JoSLE patients. Methods Forty-nine female JoSLE patients were evaluated at baseline and after a 3.5-year follow-up regarding clinical, laboratory (including bone turnover markers), areal bone mineral density (aBMD) and bone microarchitecture parameters using high-resolution peripheral quantitative computed tomography (HR-pQCT). Based on the difference between final and baseline aBMD value, the patients were divided into three groups: aBMD gain (BG), aBMD loss (BL) and aBMD no change (NC). Results The mean patient age was 18.7 +/- 3.3 years. Sixty-one percent of patients presented with aBMD gain, 18.4% aBMD loss, and 20.4% remained stable during this follow-up period. Comparing the BL with the BG group, there was a higher frequency of alcohol consumption (p = 0.009), a higher frequency of inadequate calcium intake (p = 0.047) and lower levels of baseline procollagen type 1 amino-terminal propeptide (P1NP) (p = 0.036) in the BL group. Moreover, worsening of HR-pQCT parameters trabecular volumetric density (p = 0.003) and cortical thickness (p = 0.009) was observed in the BL group. In addition, a higher frequency of renal activity was observed comparing the BL + NC with the BG group (p = 0.036). Conclusions This is the first longitudinal study that has analyzed the risk factors of bone loss in JoSLE patients. The authors emphasize the importance of evaluating lifestyle habits and renal disease activity in these young women. Furthermore, this study suggests that trabecular and cortical compartments deteriorated, and low levels of P1NP may be a predictor of bone impairment in JoSLE. | eng |
dc.description.sponsorship | Conselho Nacional de Ciencia e Tecnologia [301805/2013-0] | |
dc.description.sponsorship | Federico Foundation | |
dc.language.iso | eng | |
dc.publisher | SAGE PUBLICATIONS LTD | eng |
dc.relation.ispartof | Lupus | |
dc.rights | restrictedAccess | eng |
dc.subject | Musculoskeletal | eng |
dc.subject | renal lupus | eng |
dc.subject | systemic lupus erythematosus | eng |
dc.subject.other | vertebral fracture assessment | eng |
dc.subject.other | x-ray absorptiometry | eng |
dc.subject.other | mineral density | eng |
dc.subject.other | vitamin-d | eng |
dc.subject.other | microarchitecture | eng |
dc.subject.other | osteoporosis | eng |
dc.subject.other | alcohol | eng |
dc.subject.other | calcium | eng |
dc.subject.other | disease | eng |
dc.subject.other | deterioration | eng |
dc.title | Risk factors for bone loss in juvenile-onset systemic lupus erythematosus: a prospective study | eng |
dc.type | article | eng |
dc.rights.holder | Copyright SAGE PUBLICATIONS LTD | eng |
dc.identifier.doi | 10.1177/0961203319869467 | |
dc.identifier.pmid | 31409184 | |
dc.subject.wos | Rheumatology | eng |
dc.type.category | original article | eng |
dc.type.version | publishedVersion | eng |
hcfmusp.description.articlenumber | UNSP 0961203319869467 | |
hcfmusp.description.beginpage | 1224 | |
hcfmusp.description.endpage | 1232 | |
hcfmusp.description.issue | 10 | |
hcfmusp.description.volume | 28 | |
hcfmusp.origem | WOS | |
hcfmusp.origem.id | WOS:000483295100001 | |
hcfmusp.origem.id | 2-s2.0-85071507671 | |
hcfmusp.publisher.city | LONDON | eng |
hcfmusp.publisher.country | ENGLAND | eng |
hcfmusp.relation.reference | Berg KM, 2008, AM J MED, V121, P406, DOI 10.1016/j.amjmed.2007.12.012 | eng |
hcfmusp.relation.reference | Brandi ML, 2009, RHEUMATOLOGY, V48, pIV3, DOI 10.1093/rheumatology/kep273 | eng |
hcfmusp.relation.reference | Carbonare LD, 2004, J ENDOCRINOL INVEST, V27, P99, DOI 10.1007/BF03350919 | eng |
hcfmusp.relation.reference | Casella CB, 2012, LUPUS, V21, P1335, DOI 10.1177/0961203312454929 | eng |
hcfmusp.relation.reference | Farias Júnior José Cazuza de, 2012, Rev. bras. epidemiol., V15, P198, DOI 10.1590/S1415-790X2012000100018 | eng |
hcfmusp.relation.reference | Domiciano DS, 2013, ARTHRIT CARE RES, V65, P809, DOI 10.1002/acr.21905 | eng |
hcfmusp.relation.reference | DUKE PM, 1980, PEDIATRICS, V66, P918 | eng |
hcfmusp.relation.reference | El Maghraoui A, 2006, J CLIN DENSITOM, V9, P281, DOI 10.1016/j.jocd.2006.03.014 | eng |
hcfmusp.relation.reference | Flynn A, 2003, P NUTR SOC, V62, P851, DOI 10.1079/PNS2003301 | eng |
hcfmusp.relation.reference | Fuller H, 2015, REV BRAS REUMATOL, V55, P352, DOI [10.1016/j.rbr.2014.07.010, 10.1016/j.rbre.2014.07.010] | eng |
hcfmusp.relation.reference | Garcia-Valdecasas-Campelo E, 2006, ALCOHOL ALCOHOLISM, V41, P261, DOI 10.1093/alcalc/agl004 | eng |
hcfmusp.relation.reference | GENANT HK, 1993, J BONE MINER RES, V8, P1137, DOI 10.1002/jbmr.5650080915 | eng |
hcfmusp.relation.reference | Gladman D, 1996, ARTHRITIS RHEUM, V39, P363, DOI 10.1002/art.1780390303 | eng |
hcfmusp.relation.reference | Graves DT, 1999, FRONT BIOSCI, V4, P571 | eng |
hcfmusp.relation.reference | Haskelberg H, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0038377 | eng |
hcfmusp.relation.reference | Hlaing TT, 2014, ANN CLIN BIOCHEM, V51, P189, DOI 10.1177/0004563213515190 | eng |
hcfmusp.relation.reference | Ibanez D, 2005, J RHEUMATOL, V32, P824 | eng |
hcfmusp.relation.reference | Lee C, 2005, RHEUM DIS CLIN N AM, V31, P363, DOI 10.1016/j.rdc.2005.01.004 | eng |
hcfmusp.relation.reference | Leslie WD, 2003, GASTROENTEROLOGY, V125, P941, DOI 10.1016/S0016-5085(03)01062-X | eng |
hcfmusp.relation.reference | Lewiecki EM, 2008, BONE, V43, P1115, DOI 10.1016/j.bone.2008.08.106 | eng |
hcfmusp.relation.reference | Lilleby V, 2005, ARTHRITIS RHEUM, V52, P2051, DOI 10.1002/art.21115 | eng |
hcfmusp.relation.reference | Lim LSH, 2012, ANN RHEUM DIS, V71, P1686, DOI 10.1136/annrheumdis-2011-200805 | eng |
hcfmusp.relation.reference | Lima GL, 2018, OSTEOPOROSIS INT, V29, P587, DOI 10.1007/s00198-017-4316-5 | eng |
hcfmusp.relation.reference | Lucas R, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0046940 | eng |
hcfmusp.relation.reference | Mikosch P, 2014, WIEN MED WOCHENSCHR, V164, P15, DOI 10.1007/s10354-013-0258-5 | eng |
hcfmusp.relation.reference | NIEVES JW, 1995, AM J EPIDEMIOL, V141, P342, DOI 10.1093/aje/141.4.342 | eng |
hcfmusp.relation.reference | Paupitz JA, 2016, OSTEOPOROSIS INT, V27, P1839, DOI 10.1007/s00198-015-3461-y | eng |
hcfmusp.relation.reference | Petri M, 2012, ARTHRITIS RHEUM-US, V64, P2677, DOI 10.1002/art.34473 | eng |
hcfmusp.relation.reference | Resende AL, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0106728 | eng |
hcfmusp.relation.reference | Pereira RMR, 2010, CLINICS, V65, P1197, DOI 10.1590/S1807-59322010001100024 | eng |
hcfmusp.relation.reference | Seguro LPC, 2015, OSTEOPOROSIS INT, V26, P459, DOI 10.1007/s00198-014-2860-9 | eng |
hcfmusp.relation.reference | Suh KT, 2005, CLIN ORTHOP RELAT R, P220, DOI 10.1097/01.blo.0000150568.16133.3c | eng |
hcfmusp.relation.reference | Tang XL, 2013, LUPUS, V22, P1162, DOI 10.1177/0961203313498802 | eng |
hcfmusp.relation.reference | Tang XL, 2013, OSTEOPOROSIS INT, V24, P1817, DOI 10.1007/s00198-012-2177-5 | eng |
hcfmusp.relation.reference | Tang XL, 2012, J RHEUMATOL, V39, P1955, DOI 10.3899/jrheum.120213 | eng |
hcfmusp.relation.reference | Teichmann J, 1999, RHEUMATOL INT, V18, P137, DOI 10.1007/s002960050072 | eng |
hcfmusp.relation.reference | VALIMAKI MJ, 1994, BMJ-BRIT MED J, V309, P230, DOI 10.1136/bmj.309.6949.230 | eng |
hcfmusp.relation.reference | Vasikaran S, 2011, OSTEOPOROSIS INT, V22, P391, DOI 10.1007/s00198-010-1501-1 | eng |
hcfmusp.relation.reference | Wang YS, 2003, CLIN ORTHOP RELAT R, P213, DOI 10.1097/01.blo.0000063602.67412.83 | eng |
hcfmusp.relation.reference | Wise GE, 2002, CRIT REV ORAL BIOL M, V13, P323, DOI 10.1177/154411130201300403 | eng |
hcfmusp.relation.reference | Wosje KS, 2000, NUTR REV, V58, P253 | eng |
dc.description.index | MEDLINE | eng |
dc.identifier.eissn | 1477-0962 | |
hcfmusp.citation.scopus | 2 | - |
hcfmusp.scopus.lastupdate | 2024-03-29 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MCM Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - LIM/17 |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
art_SOUSA_Risk_factors_for_bone_loss_in_juvenileonset_systemic_2019.PDF Restricted Access | publishedVersion (English) | 106.53 kB | Adobe PDF | View/Open Request a copy |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.