Pulmonary arteriovenous malformations: diagnostic and treatment characteristics

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.author SALIBE-FILHO, William FMUSP-HC
PILOTO, Bruna Mamprim FMUSP-HC
OLIVEIRA, Ellen Pierre de FMUSP-HC
CASTRO, Marcela Araujo FMUSP-HC
MOTTA-LEAL-FILHO, Joaquim Mauricio da FMUSP-HC
dc.date.issued 2019
dc.identifier.citation JORNAL BRASILEIRO DE PNEUMOLOGIA, v.45, n.4, article ID UNSP e20180137, 7p, 2019
dc.identifier.issn 1806-3713
dc.identifier.uri http://observatorio.fm.usp.br/handle/OPI/33459
dc.description.abstract Objective: To present a case series of pulmonary arteriovenous malformations (PAVMs), describing the main clinical findings, the number/location of pulmonary vascular abnormalities, the clinical complications, and the treatment administered. Methods: This was a retrospective observational study evaluating patients with PAVM divided into two groups: hereditary hemorrhagic telangiectasia (HHT); and idiopathic PAVM (iPAVM). Results: A total of 41 patients were selected for inclusion, but only 33 had PAVMs. After clinical evaluation, 27 and 6 were diagnosed with HHT and iPAVM, respectively. In the HHT group, the mean age was 49.6 years and 88.9% were female. In that group, 4 patients had an SpO(2) of < 90% and the most common clinical finding was epistaxis. In the iPAVM group, the mean age was 48.1 years and 83.3% were female. In that group, 3 patients had an SpO(2) of < 90%. Computed tomographic pulmonary angiography showed that most of the PAVMs were in the lower lobes: 56.4% in the HHT group and 85.7% in the iPAVM group. Embolization was performed in 23 patients (in both groups). At this writing, 10 patients are scheduled to undergo the procedure. One of the patients who underwent embolization was subsequently referred for pulmonary resection. Conclusions: In both of the PAVM groups, there was a predominance of women and of fistulas located in the lower lobes. Few of the patients had respiratory symptoms, and most had an SpO(2) > 90%. The treatment chosen for all patients was percutaneous transcatheter embolization.
dc.language.iso eng
dc.relation.ispartof Jornal Brasileiro de Pneumologia
dc.rights openAccess
dc.subject Telangiectasia; hereditary hemorrhagic; Arteriovenous malformations/diagnosis; Arteriovenous malformations/therapy
dc.subject.other to-left shunt; follow-up; hypoxemia; hypertension; management
dc.title Pulmonary arteriovenous malformations: diagnostic and treatment characteristics
dc.type article
dc.description.group LIM/09
dc.identifier.doi 10.1590/1806-3713/e20180137
dc.identifier.pmid 31241656
dc.type.category original article
dc.type.version publishedVersion
hcfmusp.author SALIBE-FILHO, William:FM:
hcfmusp.author PILOTO, Bruna Mamprim:HC:INCOR
hcfmusp.author OLIVEIRA, Ellen Pierre de:HC:INCOR
hcfmusp.author CASTRO, Marcela Araujo:HC:INCOR
hcfmusp.author AFFONSO, Breno Boueri:HC:INRAD
hcfmusp.author MOTTA-LEAL-FILHO, Joaquim Mauricio da:HC:INCOR
hcfmusp.author BORTOLINI, Edgar:HC:INCOR
hcfmusp.author TERRA-FILHO, Mario:FM:MCP
hcfmusp.origem.id WOS:000482663400012
hcfmusp.origem.id 2-s2.0-85068850377
hcfmusp.publisher.city BRASILIA DF
hcfmusp.publisher.country BRAZIL
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dc.description.index MEDLINE
dc.identifier.eissn 1806-3756
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