Human papillomavirus is not associated to non-small cell lung cancer: data from a prospective cross-sectional study

Imagem de Miniatura
Arquivos
art_SILVA_Human_papillomavirus_is_not_associated_to_nonsmall_cell_2019.PDF (757.24 KB)
Citações na Scopus
10
Tipo de produção
article
Data de publicação
2019
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
BMC
Autores
SILVA, Estela Maria
MARIANO, Vania Sammartino
PASTREZ, Paula Roberta Aguiar
PINTO, Miguel Cordoba
SCAPULATEMPO-NETO, Cristovam
SYRJANEN, Kari Juhani
Citação
INFECTIOUS AGENTS AND CANCER, v.14, n.1, article ID 18, 7p, 2019
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Background The pathogenesis of lung cancer is triggered by a combination of genetic and environmental factors, being the tobacco smoke the most important risk factor. Nevertheless, the incidence of lung cancer in non-smokers is gradually increasing, which demands the search for different other etiological factors such as occupational exposure, previous lung disease, diet among others. In the early 80's a theory linked specific types of human papillomavirus (HPV) to lung cancer due to morphological similarities of a subset of bronchial squamous cell carcinomas with other HPV-induced cancers. Since then, several studies revealed variable rates of HPV DNA detection. The current study aimed to provide accurate information on the prevalence of HPV DNA in lung cancer. Methods Biopsies were collected from 77 newly diagnosed non-small cell lung cancer (NSCLC) patients treated at the Thoracic Oncology Department at Barretos Cancer Hospital. The samples were formalin fixed and paraffin embedded (FFPE), histologic analysis was performed by an experienced pathologist. DNA was extracted from FFPE material using a commercial extraction kit and HPV DNA detection was evaluated by multiplex PCR and HPV16 specific real-time PCR. Results HPV was not identified in any of the samples analysed (69). Conclusions Our data demonstrated a lack of HPV DNA in a series of NSCL cancers.
Palavras-chave
Non-small cell lung cancer, Lung neoplasms, Papillomaviridae, Papillomavirus DNA
URI
https://observatorio.fm.usp.br/handle/OPI/33466
Referências
  1. Akhtar N, 2017, CURR PROB CANCER, V41, P328, DOI 10.1016/j.currproblcancer.2017.07.002
  2. Anantharaman D, 2014, CANCER RES, V74, P3525, DOI 10.1158/0008-5472.CAN-13-3548
  3. de Oliveira THA, 2018, J CANCER RES CLIN, V144, P2367, DOI 10.1007/s00432-018-2748-8
  4. Begum S, 2003, CLIN CANCER RES, V9, P6469
  5. Bishop JA, 2012, AM J SURG PATHOL, V36, P142, DOI 10.1097/PAS.0b013e3182395c7b
  6. Chang SY, 2015, HUM PATHOL, V46, P1592, DOI 10.1016/j.humpath.2015.07.012
  7. Ciotti M, 2006, ONCOL REP, V16, P183
  8. de Freitas AC, 2016, J CANCER RES CLIN, V142, P2415, DOI 10.1007/s00432-016-2197-1
  9. Doxtader EE, 2012, HUM PATHOL, V43, P327, DOI 10.1016/j.humpath.2011.05.010
  10. Edge SB, 2010, ANN SURG ONCOL, V17, P1471, DOI 10.1245/s10434-010-0985-4
  11. Ferlay J, 2015, INT J CANCER, V136, pE359, DOI 10.1002/ijc.29210
  12. Gheit T, 2007, J CLIN MICROBIOL, V45, P2537, DOI 10.1128/JCM.00747-07
  13. Giuliani L, 2007, ANTICANCER RES, V27, P2697
  14. Halec G, 2013, INT J CANCER, V132, P63, DOI 10.1002/ijc.27605
  15. Hasegawa Y, 2014, LUNG CANCER, V83, P8, DOI 10.1016/j.lungcan.2013.10.002
  16. Iwakawa R, 2010, CANCER SCI, V101, P1891, DOI [10.1111/j.1349-7006.2010.01622, 10.1111/j.1349-7006.2010.01622.x]
  17. Joh J, 2010, EXP MOL PATHOL, V89, P222, DOI 10.1016/j.yexmp.2010.08.001
  18. Kim Y, 2018, BMC CANCER, V18, DOI 10.1186/s12885-018-4748-0
  19. Klein F, 2009, LUNG CANCER, V65, P13, DOI 10.1016/j.lungcan.2008.10.003
  20. Koshiol J, 2011, J NATL CANCER I, V103, P501, DOI 10.1093/jnci/djr003
  21. Malhotra J, 2016, EUR RESPIR J, V48, P889, DOI 10.1183/13993003.00359-2016
  22. MEISELS A, 1976, ACTA CYTOL, V20, P505
  23. Munoz N, 2006, VACCINE, V24, P1, DOI 10.1016/j.vaccine.2006.05.115
  24. Ragin C, 2014, CARCINOGENESIS, V35, P1267, DOI 10.1093/carcin/bgu038
  25. Sagerup CMT, 2014, ACTA ONCOL, V53, P952, DOI 10.3109/0284186X.2013.879608
  26. Sarchianaki E, 2014, TUMOR BIOL, V35, P3203, DOI 10.1007/s13277-013-1419-2
  27. Schmitt M, 2006, J CLIN MICROBIOL, V44, P504, DOI 10.1128/JCM.44.2.504-512.2006
  28. Singhi AD, 2010, CANCER-AM CANCER SOC, V116, P2166, DOI 10.1002/cncr.25033
  29. Srinivasan M, 2009, CARCINOGENESIS, V30, P1722, DOI 10.1093/carcin/bgp177
  30. Sun S, 2007, NAT REV CANCER, V7, P778, DOI 10.1038/nrc2190
  31. Syrjanen K, 2012, ANTICANCER RES, V32, P625
  32. Syrjanen K, 2012, ANTICANCER RES, V32, P3235
  33. SYRJANEN KJ, 1979, ARCH GESCHWULSTFORSC, V49, P436
  34. SYRJANEN KJ, 1979, RESPIRATION, V38, P299
  35. SYRJANEN KJ, 1979, ARCH GYNECOL, V227, P153, DOI 10.1007/BF02103290
  36. Thun MJ, 2002, ONCOGENE, V21, P7307, DOI 10.1038/sj.onc.1205807
  37. Travis WD, 2015, J THORAC ONCOL, V10, P1243, DOI 10.1097/JTO.0000000000000630
  38. van Boerdonk RAA, 2013, J THORAC ONCOL, V8, P711, DOI 10.1097/JTO.0b013e3182897c14
  39. Walboomers JMM, 1999, J PATHOL, V189, P12, DOI 10.1002/(SICI)1096-9896(199909)189:1<12::AID-PATH431>3.0.CO;2-F
  40. Whiteman DC, 2016, CANCER EPIDEMIOL, V44, P203, DOI 10.1016/j.canep.2016.06.013
  41. Xiong WM, 2017, ONCOTARGET, V8, P96419, DOI 10.18632/oncotarget.21682
  42. Yu Y, 2013, CLIN RESPIR J, V7, P27, DOI 10.1111/j.1752-699X.2011.00277.x
  43. Zhai K, 2015, J CLIN VIROL, V63, P84, DOI 10.1016/j.jcv.2014.09.014
  44. Zhang R, 2019, IRAN J PUBLIC HEALTH, V48, P1

Coleções
Artigos e Materiais de Revistas Científicas - FM/MDR
Artigos e Materiais de Revistas Científicas - HC/ICESP
Artigos e Materiais de Revistas Científicas - IMT
Artigos e Materiais de Revistas Científicas - LIM/14
Artigos e Materiais de Revistas Científicas - LIM/24
Artigos e Materiais de Revistas Científicas - ODS/03