Early Parental Death and Risk of Psychosis in Offspring: A Six-Country Case-Control Study
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Citações na Scopus
9
Tipo de produção
article
Data de publicação
2019
Editora
MDPI
Indexadores
Título da Revista
ISSN da Revista
Título do Volume
Autores
MISRA, Supriya
GELAYE, Bizu
KOENEN, Karestan C.
WILLIAMS, David R.
BORBA, Christina P. C.
QUATTRONE, Diego
FORTI, Marta Di
CASCIA, Caterina La
BARBERA, Daniele La
TARRICONE, Ilaria
Autor de Grupo de pesquisa
EU-GEI WP2 Grp
Editores
Coordenadores
Organizadores
Citação
JOURNAL OF CLINICAL MEDICINE, v.8, n.7, article ID 1081, 13p, 2019
Resumo
Evidence for early parental death as a risk factor for psychosis in offspring is inconclusive. We analyzed data from a six-country, case-control study to examine the associations of early parental death, type of death (maternal, paternal, both), and child's age at death with psychosis, both overall and by ethnic group. In fully adjusted multivariable mixed-effects logistic regression models, experiencing early parental death was associated with 1.54-fold greater odds of psychosis (95% confidence interval (CI): 1.23, 1.92). Experiencing maternal death had 2.27-fold greater odds (95% CI: 1.18, 4.37), paternal death had 1.14-fold greater odds (95% CI: 0.79, 1.64), and both deaths had 4.42-fold greater odds (95% CI: 2.57, 7.60) of psychosis compared with no early parental death. Experiencing parental death between 11 and 16 years of age had 2.03-fold greater odds of psychosis than experiencing it before five years of age (95% CI: 1.02, 4.04). In stratified analyses, experiencing the death of both parents had 9.22-fold greater odds of psychosis among minority ethnic groups (95% CI: 2.02-28.02) and no elevated odds among the ethnic majority (odds ratio (OR): 0.96; 95% CI: 0.10-8.97), which could be due in part to the higher prevalence of early parental death among minority ethnic groups but should be interpreted cautiously given the wide confidence intervals.
Palavras-chave
childhood adversities, early parental death, early bereavement, ethnic minorities, psychosis, schizophrenia, population-based, case-control, multi-country
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