A Systematic Review and International Web-Based Survey of Randomized Controlled Trials in the Perioperative and Critical Care Setting: Interventions Increasing Mortality

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art_SARTINI_A_Systematic_Review_and_International_WebBased_Survey_of_2019.PDF (1.12 MB)
Citações na Scopus
10
Tipo de produção
article
Data de publicação
2019
Editora
W B SAUNDERS CO-ELSEVIER INC
DOI
Indexadores
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Autores
SARTINI, Chiara
LOMIVOROTOV, Vladimir
PISANO, Antonio
RIHA, Hynek
REDAELLI, Martina Baiardo
LOPEZ-DELGADO, Juan Carlos
PIERI, Marina
FOMINSKIY, Evgeny
LIKHVANTSEV, Valery
Autor de Grupo de pesquisa
Editores
Coordenadores
Organizadores
Citação
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA, v.33, n.10, p.2685-2694, 2019
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Objective: Reducing mortality is a key target in critical care and perioperative medicine. The authors aimed to identify all nonsurgical interventions (drugs, techniques, strategies) shown by randomized trials to increase mortality in these clinical settings. Design: A systematic review of the literature followed by a consensus-based voting process. Setting: A web-based international consensus conference. Participants: Two hundred fifty-one physicians from 46 countries. Interventions: The authors performed a systematic literature search and identified all randomized controlled trials (RCTs) showing a significant increase in unadjusted landmark mortality among surgical or critically ill patients. The authors reviewed such studies during a meeting by a core group of experts. Studies selected after such review advanced to web-based voting by clinicians in relation to agreement, clinical practice, and willingness to include each intervention in international guidelines. Measurements and Main Results: The authors selected 12 RCTs dealing with 12 interventions increasing mortality: diaspirin-crosslinked hemoglobin (92% of agreement among web voters), overfeeding, nitric oxide synthase inhibitor in septic shock, human growth hormone, thyroxin in acute kidney injury, intravenous salbutamol in acute respiratory distress syndrome, plasma-derived protein C concentrate, aprotinin in high-risk cardiac surgery, cysteine prodrug, hypothermia in meningitis, methylprednisolone in traumatic brain injury, and albumin in traumatic brain injury (72% of agreement). Overall, a high consistency (ranging from 80% to 90%) between agreement and clinical practice was observed. Conclusion: The authors identified 12 clinical interventions showing increased mortality supported by randomized controlled trials with nonconflicting evidence, and wide agreement upon clinicians on a global scale.
Palavras-chave
anesthesia, mortality, consensus conference, critically ill, perioperative, democracy-based medicine
URI
https://observatorio.fm.usp.br/handle/OPI/33973
Referências
  1. Acker CG, 2000, KIDNEY INT, V57, P293, DOI 10.1046/j.1523-1755.2000.00827.x
  2. Annane D, 2013, JAMA-J AM MED ASSOC, V310, P1809, DOI 10.1001/jama.2013.280502
  3. Bellomo R., 2014, REDUCING MORTALITY P, P1
  4. Blessberger H, 2014, COCHRANE DB SYST REV, V9
  5. BONE RC, 1987, NEW ENGL J MED, V317, P653, DOI 10.1056/NEJM198709103171101
  6. Bouri S, 2014, HEART, V100, P456, DOI 10.1136/heartjnl-2013-304262
  7. Braunschweig CA, 2015, JPEN-PARENTER ENTER, V39, P13, DOI 10.1177/0148607114528541
  8. Devereaux PJ, 2008, LANCET, V371, P1839, DOI 10.1016/S0140-6736(08)60601-7
  9. Devereaux PJ, 2015, NEW ENGL J MED, V373, P2258, DOI 10.1056/NEJMra1502824
  10. Ferguson ND, 2013, NEW ENGL J MED, V368, P795, DOI 10.1056/NEJMoa1215554
  11. Fergusson DA, 2008, NEW ENGL J MED, V358, P2319, DOI 10.1056/NEJMoa0802395
  12. Finfer S, 2009, NEW ENGL J MED, V360, P1283, DOI 10.1056/NEJMoa0810625
  13. Fuchs C, 2017, BRIT J ANAESTH, V119, P616, DOI 10.1093/bja/aex231
  14. Giakoumidakis K, 2013, HEART LUNG, V42, P146, DOI 10.1016/j.hrtlng.2012.12.007
  15. Greco M, 2015, J CARDIOTHOR VASC AN, V29, P506, DOI 10.1053/j.jvca.2014.11.005
  16. Kristensen SD, 2014, EUR HEART J, V35, P2383, DOI 10.1093/eurheartj/ehu282
  17. Landoni G, 2018, J CARDIOTHOR VASC AN, V32, P225, DOI 10.1053/j.jvca.2017.06.017
  18. Landoni G, 2017, J CARDIOTHOR VASC AN, V31, P719, DOI 10.1053/j.jvca.2016.07.017
  19. Landoni G, 2015, CRIT CARE MED, V43, P1559, DOI 10.1097/CCM.0000000000000974
  20. Landoni G, 2013, J CARDIOTHOR VASC AN, V27, P1384, DOI 10.1053/j.jvca.2013.06.028
  21. Lazar HL, 2004, CIRCULATION, V109, P1497, DOI 10.1161/01.CIR.0000121747.71054.79
  22. Lopez A, 2004, CRIT CARE MED, V32, P21, DOI 10.1097/01.CCM.0000105581.01815.C6
  23. Maca J, 2017, RESP CARE, V62, P113, DOI 10.4187/respcare.04716
  24. Morris PE, 2008, CRIT CARE MED, V36, P782, DOI 10.1097/CCM.0B013E318164E7E4
  25. Mourvillier B, 2013, JAMA-J AM MED ASSOC, V310, P2174, DOI 10.1001/jama.2013.280506
  26. Muzha I, 2004, LANCET, V364, P1321
  27. Myburgh J, 2007, NEW ENGL J MED, V357, P874
  28. Pappalardo F, 2016, INTENS CARE MED, V42, P1706, DOI 10.1007/s00134-016-4405-5
  29. Pearse RM, 2012, LANCET, V380, P1059, DOI 10.1016/S0140-6736(12)61148-9
  30. Perner A, 2012, NEW ENGL J MED, V367, P124, DOI 10.1056/NEJMoa1204242
  31. Pisano A, 2019, KAPLANS ESSENTIALS C, P538
  32. Pisano A, 2016, MINERVA ANESTESIOL, V82, P1107
  33. Pisano A, 2016, J CARDIOTHOR VASC AN, V30, P1386, DOI 10.1053/j.jvca.2016.05.005
  34. Ripolles Melchor J, 2016, MINERVA ANESTESIOL, V82, P1039
  35. Sartini C, 2018, J CARDIOTHORAC VASC
  36. Singer M, 2016, JAMA-J AM MED ASSOC, V315, P801, DOI 10.1001/jama.2016.0287
  37. Sloan EP, 1999, JAMA-J AM MED ASSOC, V282, P1857, DOI 10.1001/jama.282.19.1857
  38. Smith FG, 2012, LANCET, V379, P229, DOI 10.1016/S0140-6736(11)61623-1
  39. Takala J, 1999, NEW ENGL J MED, V341, P785, DOI 10.1056/NEJM199909093411102
  40. Van den Berghe G, 2006, NEW ENGL J MED, V354, P449, DOI 10.1056/NEJMoa052521
  41. Van den Berghe G, 2001, NEW ENGL J MED, V345, P1359, DOI 10.1056/NEJMoa011300
  42. Weiser TG, 2008, LANCET, V372, P139, DOI 10.1016/S0140-6736(08)60878-8
  43. Wijeysundera DN, 2014, CIRCULATION, V130, P2246, DOI 10.1161/CIR.0000000000000104
  44. Zimmerman JE, 2013, CRIT CARE, V17, DOI 10.1186/cc12695

Coleções
Artigos e Materiais de Revistas Científicas - FM/MCP
Artigos e Materiais de Revistas Científicas - HC/ICESP
Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - LIM/08