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DC Field | Value | Language |
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dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | |
dc.contributor.author | MURAI, Igor H. | |
dc.contributor.author | ROSCHEL, Hamilton | |
dc.contributor.author | DANTAS, Wagner S. | |
dc.contributor.author | GIL, Saulo | |
dc.contributor.author | MEREGE-FILHO, Carlos | |
dc.contributor.author | CLEVA, Roberto de | |
dc.contributor.author | SA-PINTO, Ana L. De | |
dc.contributor.author | LIMA, Fernanda | |
dc.contributor.author | SANTO, Marco A. | |
dc.contributor.author | BENATTI, Fabiana B. | |
dc.contributor.author | KIRWAN, John P. | |
dc.contributor.author | PEREIRA, Rosa M. | |
dc.contributor.author | GUALANO, Bruno | |
dc.date.accessioned | 2019-11-06T18:47:21Z | - |
dc.date.available | 2019-11-06T18:47:21Z | - |
dc.date.issued | 2019 | |
dc.identifier.citation | JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, v.104, n.10, p.4639-4650, 2019 | |
dc.identifier.issn | 0021-972X | |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/34009 | - |
dc.description.abstract | Context: Bone loss after bariatric surgery potentially could be mitigated by exercise. Objective: To investigate the role of exercise training (ET) in attenuating bariatric surgery-induced bone loss. Design: Randomized, controlled trial. Setting: Referral center for bariatric surgery. Patients: Seventy women with severe obesity, aged 25 to 55 years, who underwent Roux-en-Y gastric bypass (RYGB). Intervention: Supervised, 6-month, ET program after RYGB vs. standard of care (RYGB only). Outcomes: Areal bone mineral density (aBMD) was the primary outcome. Bone microarchitecture, bone turnover, and biochemical markers were secondary outcomes. Results: Surgery significantly decreased femoral neck, total hip, distal radius, and whole body aBMD (P < 0.001); and increased bone turnover markers, including collagen type I C-telopeptide (CTX), procollagen type I N-propeptide (P1NP), sclerostin, and osteopontin (P < 0.05). Compared with RYGB only, exercise mitigated the percent loss of aBMD at femoral neck [estimated mean difference (EMD), -2.91%; P = 0.007;], total hip (EMD, -2.26%; P = 0.009), distal radius (EMD, -1.87%; P = 0.038), and cortical volumetric bone mineral density at distal radius (EMD, -2.09%; P = 0.024). Exercise also attenuated CTX (EMD, -0.20 ng/mL; P = 0.002), P1 NP (EMD, -17.59 ng/mL; P = 0.024), and sclerostin levels (EMD, -610 pg/mL; P = 0.046) in comparison with RYGB. Exercise did not affect biochemical markers (e.g., 25(OH)D, calcium, intact PTH, phosphorus, and magnesium). Conclusion: Exercise mitigated bariatric surgery-induced bone loss, possibly through mechanisms involving suppression in bone turnover and sclerostin. Exercise should be incorporated in postsurgery care to preserve bone mass. | eng |
dc.description.sponsorship | Fundacao de Amparo a Pesquisa do Estado de Sao PauloFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2015/02833-5, 2016/10993-5, 2017/01427-9] | |
dc.description.sponsorship | Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior Brasil (CAPES)CAPES [001] | |
dc.language.iso | eng | |
dc.publisher | ENDOCRINE SOC | eng |
dc.relation.ispartof | Journal of Clinical Endocrinology & Metabolism | |
dc.rights | restrictedAccess | eng |
dc.subject.other | bariatric surgery | eng |
dc.subject.other | postmenopausal women | eng |
dc.subject.other | structural-changes | eng |
dc.subject.other | body-composition | eng |
dc.subject.other | sclerostin | eng |
dc.subject.other | association | eng |
dc.subject.other | mass | eng |
dc.subject.other | density | eng |
dc.subject.other | metabolism | eng |
dc.subject.other | resistance | eng |
dc.title | Exercise Mitigates Bone Loss in Women With Severe Obesity After Roux-en-Y Gastric Bypass: A Randomized Controlled Trial | eng |
dc.type | article | eng |
dc.rights.holder | Copyright ENDOCRINE SOC | eng |
dc.identifier.doi | 10.1210/jc.2019-00074 | |
dc.identifier.pmid | 31322672 | |
dc.subject.wos | Endocrinology & Metabolism | eng |
dc.type.category | original article | eng |
dc.type.version | publishedVersion | eng |
hcfmusp.author.external | MURAI, Igor H.:Univ Sao Paulo, Appl Physiol & Nutr Res Grp, Lab Assessment & Conditioning Rheumatol, Sch Phys Educ & Sport,Hosp Clin HCFMUSP,Fac Med F, BR-01246903 Sao Paulo, Brazil | |
hcfmusp.author.external | DANTAS, Wagner S.:Univ Sao Paulo, Appl Physiol & Nutr Res Grp, Lab Assessment & Conditioning Rheumatol, Sch Phys Educ & Sport,Hosp Clin HCFMUSP,Fac Med F, BR-01246903 Sao Paulo, Brazil | |
hcfmusp.author.external | GIL, Saulo:Univ Sao Paulo, Appl Physiol & Nutr Res Grp, Lab Assessment & Conditioning Rheumatol, Sch Phys Educ & Sport,Hosp Clin HCFMUSP,Fac Med F, BR-01246903 Sao Paulo, Brazil | |
hcfmusp.author.external | MEREGE-FILHO, Carlos:Univ Sao Paulo, Appl Physiol & Nutr Res Grp, Lab Assessment & Conditioning Rheumatol, Sch Phys Educ & Sport,Hosp Clin HCFMUSP,Fac Med F, BR-01246903 Sao Paulo, Brazil | |
hcfmusp.author.external | KIRWAN, John P.:Pennington Biomed Res Ctr, Integrat Physiol & Mol Metab Grp, Baton Rouge, LA 70808 USA | |
hcfmusp.description.beginpage | 4639 | |
hcfmusp.description.endpage | 4650 | |
hcfmusp.description.issue | 10 | |
hcfmusp.description.volume | 104 | |
hcfmusp.origem | WOS | |
hcfmusp.origem.id | WOS:000489712300045 | |
hcfmusp.origem.id | 2-s2.0-85071995465 | |
hcfmusp.publisher.city | WASHINGTON | eng |
hcfmusp.publisher.country | USA | eng |
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dc.description.index | MEDLINE | eng |
dc.identifier.eissn | 1945-7197 | |
hcfmusp.citation.scopus | 49 | - |
hcfmusp.scopus.lastupdate | 2024-03-29 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MCM Artigos e Materiais de Revistas Científicas - FM/MGT Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - LIM/17 Artigos e Materiais de Revistas Científicas - LIM/35 Artigos e Materiais de Revistas Científicas - ODS/03 |
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