A generalizable method for estimating duration of HIV infections using clinical testing history and HIV test results
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Citações na Scopus
15
Tipo de produção
article
Data de publicação
2019
Título da Revista
ISSN da Revista
Título do Volume
Editora
LIPPINCOTT WILLIAMS & WILKINS
Autores
PILCHER, Christopher D.
PORCO, Travis C.
FACENTE, Shelley N.
GREBE, Eduard
DELANEY, Kevin P.
MASCIOTRA, Silvina
KASSANJEE, Reshma
BUSCH, Michael P.
MURPHY, Gary
OWEN, S. Michele
Autor de Grupo de pesquisa
Consortium Evaluation Performance
Citação
AIDS, v.33, n.7, p.1231-1240, 2019
Resumo
Objective: To determine the precision of new and established methods for estimating duration of HIV infection. Design: A retrospective analysis of HIV testing results from serial samples in commercially available panels, taking advantage of extensive testing previously conducted on 53 seroconverters. Methods: We initially investigated four methods for estimating infection timing: method 1, 'Fiebig stages' based on test results from a single specimen; method 2, an updated '4th gen' method similar to Fiebig stages but using antigen/antibody tests in place of the p24 antigen test; method 3, modeling of 'viral ramp-up' dynamics using quantitative HIV-1 viral load data from antibody-negative specimens; and method 4, using detailed clinical testing history to define a plausible interval and best estimate of infection time. We then investigated a 'two-step method' using data from both methods 3 and 4, allowing for test results to have come from specimens collected on different days. Results: Fiebig and '4th gen' staging method estimates of time since detectable viremia had similar and modest correlation with observed data. Correlation of estimates from both new methods (3 and 4), and from a combination of these two ('two-step method') was markedly improved and variability significantly reduced when compared with Fiebig estimates on the same specimens. Conclusion: The new 'two-step' method more accurately estimates timing of infection and is intended to be generalizable to more situations in clinical medicine, research, and surveillance than previous methods. An online tool is now available that enables researchers/clinicians to input data related to method 4, and generate estimated dates of detectable infection.
Palavras-chave
duration of infection, HIV disease staging, HIV infection dating, HIV staging, HIV testing
Referências
- Ananworanich J, 2013, RETROVIROLOGY, V10, DOI 10.1186/1742-4690-10-56
- Cohen MS, 2010, J INFECT DIS, V202, pS270, DOI 10.1086/655651
- Cohen SE, 2019, LANCET HIV, V6, pE43, DOI 10.1016/S2352-3018(18)30288-1
- da Motta LR, 2013, J VIROL METHODS, V194, P132, DOI 10.1016/j.jviromet.2013.08.016
- Delaney KP, 2017, SEX TRANSM DIS, V44, P747, DOI 10.1097/OLQ.0000000000000736
- Delaney KP, 2017, CLIN INFECT DIS, V64, P53, DOI 10.1093/cid/ciw666
- Donnell D, 2017, AIDS, V31, P2007, DOI [10.1097/QAD.0000000000001577, 10.1097/qad.0000000000001577]
- Eller L, 2013, C RETR OPP INF CROI
- Fidler S, 2013, NEW ENGL J MED, V368, P207, DOI 10.1056/NEJMoa1110039
- Fiebig EW, 2003, AIDS, V17, P1871, DOI 10.1097/00002030-200309050-00005
- Grebe E., 2018, BIORXIV, DOI [10.1101/323808, DOI 10.1101/323808]
- Green N, 2017, AIDS, V31, P287, DOI 10.1097/QAD.0000000000001308
- Grinsztejn B, 2014, LANCET INFECT DIS, V14, P281, DOI 10.1016/S1473-3099(13)70692-3
- Henrich TJ, 2017, PLOS MED, V14, DOI 10.1371/journal.pmed.1002417
- Herout S, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0152910
- Kuhar DT, 2013, INFECT CONT HOSP EP, V34, P875, DOI 10.1086/672271
- Li JZ, 2016, AIDS, V30, P343, DOI 10.1097/QAD.0000000000000953
- Lundgren D, 2015, NEW ENGL J MED, V373, P795, DOI 10.1056/NEJMoa1506816
- Masciotra S, 2013, J CLIN VIROL, V58, pE54, DOI 10.1016/j.jcv.2013.07.002
- Masciotra S, 2011, J CLIN VIROL, V52, pS17, DOI 10.1016/j.jcv.2011.09.011
- Moyer VA, 2013, ANN INTERN MED, V159, P349, DOI 10.7326/0003-4819-159-5-201309030-00672
- Murphy G, 2017, EPIDEMIOL INFECT, V145, P925, DOI 10.1017/S0950268816002910
- Owen SM, 2008, J CLIN MICROBIOL, V46, P1588, DOI 10.1128/JCM.02196-07
- Panel on Treatment of Pregnant Women with HIV Infection and Prevention of Perinatal Transmission, 2018, REC US ANT DRUGS TRA
- Perry KR, 2008, TRANSFUSION MED, V18, P228, DOI 10.1111/j.1365-3148.2008.00874.x
- Pilcher CD, 2017, JAIDS-J ACQ IMM DEF, V74, P44, DOI 10.1097/QAI.0000000000001134
- Priddy FH, 2007, JAIDS-J ACQ IMM DEF, V44, P196, DOI 10.1097/01.qai.0000254323.86897.36
- Rosenberg ES, 2000, NATURE, V407, P523, DOI 10.1038/35035103
- Rutstein SE, 2017, J INT AIDS SOC, V20, DOI 10.7448/IAS.20.1.21579
- Takata H, 2017, SCI TRANSL MED, V9, DOI 10.1126/scitranslmed.aag1809
- UNAIDS/WHO Working Group on Global HIV/AIDS and STI Surveillance, 2011, US ASS REC INF EST H