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https://observatorio.fm.usp.br/handle/OPI/34027
Title: | MTTP polymorphisms and hepatic steatosis in individuals chronically infected with hepatitis C virus |
Authors: | PRATA, Thamiris Vaz Gago; SILVA, Dayane de Souza Rodrigues da; MANCHIERO, Caroline; DANTAS, Bianca Peixoto; MAZZA, Celso Carmo; NUNES, Arielle Karen da Silva; ABDALA, Edson; FIGUEIREDO, Gerusa Maria; TENGAN, Fatima Mitiko; MAGRI, Mariana Cavalheiro |
Citation: | ARCHIVES OF VIROLOGY, v.164, n.10, p.2559-2563, 2019 |
Abstract: | Polymorphisms in the microsomal triglyceride transfer protein (MTTP) gene were genotyped in individuals who were chronically infected with hepatitis C virus (HCV). In the 236 patients, the frequencies of risk alleles of the -164T/C (rs1800804), -400A/T (rs1800803) and H297Q (rs2306985) polymorphisms were 0.30, 0.41 and 0.50, respectively. A significant association between the risk alleles of the -164T/C and -400A/T polymorphisms combined with HCV genotype 3 infection and the occurrence of steatosis was detected (p = 0.004 and p = 0.032), suggesting that a combination of host and viral factors can potentially be used to predict hepatic steatosis. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MIP Artigos e Materiais de Revistas Científicas - FM/MPR Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - HC/InCor Artigos e Materiais de Revistas Científicas - LIM/47 Artigos e Materiais de Revistas Científicas - LIM/52 Artigos e Materiais de Revistas Científicas - ODS/03 |
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