The effectiveness of maternal pertussis vaccination in protecting newborn infants in Brazil: A case-control study
Carregando...
Citações na Scopus
27
Tipo de produção
article
Data de publicação
2019
Título da Revista
ISSN da Revista
Título do Volume
Editora
ELSEVIER SCI LTD
Autores
FERNANDES, Eder Gatti
SATO, Ana Paula S.
VAZ-DE-LIMA, Lourdes R. A.
RODRIGUES, Marcela
LEITE, Daniela
BRITO, Cyro A. de
CARVALHANAS, Telma Regina M. P.
RAMOS, Maria Ligia Bacciote Nerger
SATO, Helena Keico
Citação
VACCINE, v.37, n.36, p.5481-5484, 2019
Resumo
Introduction: In 2014, the Brazilian Ministry of Health (MoH) recommended Tdap to pregnant women in response to a significant increase in the incidence of pertussis among infants. The present study assessed the effectiveness of maternal immunization in preventing pertussis in infants. Methods: An unmatched case-control study was undertaken in Sao Paulo State, Brazil from February 2015 to July 2016. Cases were infants aged <8 weeks at onset of pertussis reported to the Surveillance System and confirmed by real-time polymerase chain reaction or culture. Four to six healthy infants were selected as controls per case from birth certificates in the Information System on Live Births database. General characteristics and mother's vaccination status were compared between cases and controls. The vaccine effectiveness (VE) was calculated as 1 - odds ratio (OR). For the adjusted VE, the OR was calculated using logistic regression analysis. Results: Forty-two cases and 248 controls were enrolled in the study. Mothers of 8 cases (19.1%) and 143 controls (57.4%) were vaccinated during pregnancy, resulting in an unadjusted VE of 82.6% (95% confidence interval [CI], 60.8-92.3%). The VE was unchanged after adjusting for maternal age and monthly household income. Conclusion: Maternal pertussis vaccination during pregnancy was effective in protecting infants aged <8 weeks from pertussis.
Palavras-chave
Bordetella pertussis, Maternal immunization, Pertussis vaccine, Case-control study, Brazil
Referências
- Abu Raya B, 2016, CLIN INFECT DIS, V63, P143, DOI 10.1093/cid/ciw233
- Amirthalingam G, 2014, LANCET, V384, P1521, DOI 10.1016/S0140-6736(14)60686-3
- [Anonymous], 2015, Wkly Epidemiol Rec, V90, P433
- Baxter R, 2017, PEDIATRICS, V139, DOI 10.1542/peds.2016-4091
- Dabrera G, 2015, CLIN INFECT DIS, V60, P333, DOI 10.1093/cid/ciu821
- Eberhardt CS, 2016, CLIN INFECT DIS, V62, P829, DOI 10.1093/cid/ciw027
- Arlant LHF, 2014, EXPERT REV ANTI-INFE, V12, P1265, DOI 10.1586/14787210.2014.948846
- Fernandes EG, 2018, BMC INFECT DIS, V18, DOI 10.1186/s12879-018-3004-1
- Guimaraes LM, 2015, BMC INFECT DIS, V15, DOI 10.1186/s12879-015-1222-3
- Mattoo S, 2005, CLIN MICROBIOL REV, V18, P326, DOI 10.1128/CMR.18.2.326-382.2005
- Naidu MA, 2016, AM J OBSTET GYNECOL, V215, DOI 10.1016/j.ajog.2016.03.002
- Skoff TH, 2017, CLIN INFECT DIS, V65, P1977, DOI 10.1093/cid/cix724
- Tan Tina, 2005, Pediatr Infect Dis J, V24, pS10, DOI 10.1097/01.inf.0000160708.43944.99