Association of Sarcopenia With Performance on Multiple Cognitive Domains: Results From the ELSA-Brasil Study

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art_SZLEJF_Association_of_Sarcopenia_With_Performance_on_Multiple_Cognitive_2019.PDF (163.08 KB)
Citações na Scopus
26
Tipo de produção
article
Data de publicação
2019
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
OXFORD UNIV PRESS INC
Autores
Citação
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, v.74, n.11, p.1805-1811, 2019
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Background: Sarcopenia and cognitive impairment share pathophysiological paths and risk factors. Our aim was to investigate the association of sarcopenia and its defining components with cognitive performance in middle-aged and older adults. Methods: This cross-sectional analysis included 5,038 participants from the ELSA-Brasil Study, aged >= 55 years. Muscle mass was evaluated by bioelectrical impedance analysis and muscle strength by handgrip strength. Sarcopenia was defined according to the Foundation for the National Institutes of Health. Cognition was evaluated using delayed word recall test, semantic verbal fluency test, and trail making test version B. Possible confounders included sociodemographic characteristics, lifestyle, and clinical comorbidities. Results: The frequencies of sarcopenia, low muscle mass, and low muscle strength were 1.8%, 23.3%, and 4.4%, respectively. After adjustment for possible confounders, poorer performance on the verbal fluency test was associated with sarcopenia (beta = -0.20, 95% confidence interval [CI] = -0.38; -0.01, p = .03) and low muscle mass (beta = -0.08, 95% CI = -0.14; -0.01, p = .02). Low muscle strength was associated with poorer performance in the delayed word recall test (beta = -0.14, 95% CI = -0.27; -0.02, p = .02), verbal fluency test (beta = -0.14, 95% CI = -0.26; -0.02, p = .03), and trail making test (beta = -0.15, 95% CI = -0.27; -0.03, p = .01). Conclusions: Sarcopenia was associated with poorer performance on the verbal fluency test, and low muscle strength was associated with poorer performance in all cognitive tests in middle-aged and older adults.
Palavras-chave
Muscle mass, Muscle strength, Cognition, Older adult
URI
https://observatorio.fm.usp.br/handle/OPI/34284
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MCM
Artigos e Materiais de Revistas Científicas - HU
Artigos e Materiais de Revistas Científicas - LIM/20
Artigos e Materiais de Revistas Científicas - LIM/66