Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration

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art_NOORDAM_Multiancestry_sleepbySNP_interaction_analysis_in_126926_individuals_reveals_2019.PDF (2.18 MB)
Citações na Scopus
48
Tipo de produção
article
Data de publicação
2019
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
NATURE PUBLISHING GROUP
Autores
NOORDAM, Raymond
BOS, Maxime M.
WANG, Heming
WINKLER, Thomas W.
BENTLEY, Amy R.
KILPELAINEN, Tuomas O.
VRIES, Paul S. de
SUNG, Yun Ju
SCHWANDER, Karen
CADE, Brian E.
Citação
NATURE COMMUNICATIONS, v.10, article ID 5121, 13p, 2019
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Both short and long sleep are associated with an adverse lipid profile, likely through different biological pathways. To elucidate the biology of sleep-associated adverse lipid profile, we conduct multi-ancestry genome-wide sleep-SNP interaction analyses on three lipid traits (HDL-c, LDL-c and triglycerides). In the total study sample (discovery + replication) of 126,926 individuals from 5 different ancestry groups, when considering either long or short total sleep time interactions in joint analyses, we identify 49 previously unreported lipid loci, and 10 additional previously unreported lipid loci in a restricted sample of European-ancestry cohorts. In addition, we identify new gene-sleep interactions for known lipid loci such as LPL and PCSK9. The previously unreported lipid loci have a modest explained variance in lipid levels: most notable, gene-short-sleep interactions explain 4.25% of the variance in triglyceride level. Collectively, these findings contribute to our understanding of the biological mechanisms involved in sleep-associated adverse lipid profiles.
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URI
https://observatorio.fm.usp.br/handle/OPI/34324
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Artigos e Materiais de Revistas Científicas - FM/MCP
Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - LIM/13