Fecal bile acid profile after Roux-en-Y gastric bypass and its association with the remission of type 2 diabetes in obese women: A preliminary study

Imagem de Miniatura
Arquivos
art_CARDINELLI_Fecal_bile_acid_profile_after_RouxenY_gastric_bypass_2019.PDF (995.55 KB)
Citações na Scopus
18
Tipo de produção
article
Data de publicação
2019
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
CHURCHILL LIVINGSTONE
Autores
PUDENZI, Marcos Albieri
ANGOLINI, Celio Fernando F.
EBERLIN, Marcos N.
Citação
CLINICAL NUTRITION, v.38, n.6, p.2906-2912, 2019
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Objective: To assess the influence of Roux-en-Y gastric by-pass (RYGB) on fecal bile acid (BA) profile and its relationship with postoperative remission of type 2 diabetes (T2D). Methods: Fecal samples were collected 3 and 12 months after RYGB from diabetic obese women who were responsive (n = 12) and non-responsive (n = 8) to postoperative remission of T2D. Fecal BA profile was accessed by liquid chromatography coupled to tandem mass spectrometry in a targeted approach. Results: Relative to pre-operative levels, a total of 10 fecal BA profiles decreased after RYGB (ANOVA, p <= 0.05) with significant fold-changes for glycochenodeoxycholic, glycocholic, taurocholic, and taurochenodeoxycholic acids at 3-months postoperatively, and for glycochenodeoxycholic, glycocholic and taurocholic acids at 12 months postoperatively (Benjamini-Hochberg, p < 0.05). Postoperative changes in fecal BA were different between responsive and non-responsive women, with a significant reduction in more sub-fractions of BA in responsive women than in non-responsive women, and a marked difference in the temporal behavior of cholic acid (CA) and chenodeoxycholic acid (CDCA), thus reflecting changes in CA/CDCA ratio, and tauroursodeoxycolic (TUDCA) levels between these responsiveness groups (ANOVA, p <= 0.05). Conclusion: RYGB induces a marked reduction in the concentration of fecal BA, which is heterogeneous according to T2D responsiveness.
Palavras-chave
Fecal bile acids, Bariatric surgery, Type 2 diabetes
URI
https://observatorio.fm.usp.br/handle/OPI/34410
Referências
  1. BENJAMINI Y, 1995, J R STAT SOC B, V57, P289
  2. Bhutta HY, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0122273
  3. Buchwald H, 2004, JAMA-J AM MED ASSOC, V292, P1724, DOI 10.1001/jama.292.14.1724
  4. Buse JB, 2009, DIABETES CARE, V32, P2133, DOI 10.2337/dc09-9036
  5. Chiang JYL, 2013, COMPR PHYSIOL, V3, P1191, DOI 10.1002/cphy.c120023
  6. Chiang JYL, 2009, J LIPID RES, V50, P1955, DOI 10.1194/jlr.R900010-JLR200
  7. da Silva MM, 2014, NUTR HOSP, V30, P1240, DOI 10.3305/nh.2014.30.6.7828
  8. Fiorucci S, 2015, TRENDS MOL MED, V21, P702, DOI 10.1016/j.molmed.2015.09.001
  9. Graessler J, 2013, PHARMACOGENOMICS J, V13, P514, DOI 10.1038/tpj.2012.43
  10. Halilbasic E, 2013, J HEPATOL, V58, P155, DOI 10.1016/j.jhep.2012.08.002
  11. Jurate K, 2017, ANN HEPATOL, V16, P569, DOI 10.5604/01.3001.0010.0294
  12. Kars M, 2010, DIABETES, V59, P1899, DOI 10.2337/db10-0308
  13. KIMURA A, 1991, J PEDIATR GASTR NUTR, V12, P383, DOI 10.1097/00005176-199104000-00018
  14. Kohli R, 2013, J CLIN ENDOCR METAB, V98, pE708, DOI 10.1210/jc.2012-3736
  15. Kong LC, 2013, AM J CLIN NUTR, V98, P16, DOI 10.3945/ajcn.113.058743
  16. Kumar DP, 2016, J BIOL CHEM, V291, P6626, DOI 10.1074/jbc.M115.699504
  17. Lee YY, 2010, BIOCHEM BIOPH RES CO, V397, P735, DOI 10.1016/j.bbrc.2010.06.022
  18. Li Tiangang, 2015, Adv Pharmacol, V74, P263, DOI 10.1016/bs.apha.2015.04.003
  19. Lindqvist A, 2017, PLOS ONE, V12, DOI [10.1371/journal.pone.013137, 10.1371/journal.pone.0173137]
  20. Maggard MA, 2005, ANN INTERN MED, V142, P547, DOI 10.7326/0003-4819-142-7-200504050-00013
  21. Martineau MG, 2015, DIABETES CARE, V38, P243, DOI 10.2337/dc14-2143
  22. Matsuzaki Y, 2002, BBA-MOL BASIS DIS, V1588, P139, DOI 10.1016/S0925-4439(02)00157-6
  23. NAGENGAST FM, 1995, EUR J CANCER, V31A, P1067, DOI 10.1016/0959-8049(95)00216-6
  24. Nie YF, 2015, J ZHEJIANG UNIV-SC B, V16, P436, DOI 10.1631/jzus.B1400327
  25. Ocvirk Soren, 2017, Curr Nutr Rep, V6, P315, DOI 10.1007/s13668-017-0219-5
  26. Paridaens A, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18010214
  27. Pires M. J., 2004, Revista Portuguesa de Ciencias Veterinarias, V99, P137
  28. PORIES WJ, 1995, ANN SURG, V222, P339, DOI 10.1097/00000658-199509000-00011
  29. Ramsay SL, 2012, U.S. Patent, Patent No. [US8265877 B2, 8265877, 8,265,877]
  30. Ridlon JM, 2014, CURR OPIN GASTROEN, V30, P332, DOI 10.1097/MOG.0000000000000057
  31. Risstad H, 2017, SURG OBES RELAT DIS, V13, P1544, DOI 10.1016/j.soard.2017.05.024
  32. Sala P, 2016, J INT MED RES, V44, P1359, DOI 10.1177/0300060516667862
  33. Schauer PR, 2003, ANN SURG, V238, P467, DOI 10.1097/01.sla.0000089851.41115.1b
  34. Steinert RE, 2013, OBESITY, V21, pE660, DOI 10.1002/oby.20522
  35. Team R. Core, 2015, R LANG ENV STAT COMP
  36. Thomas C, 2009, CELL METAB, V10, P167, DOI 10.1016/j.cmet.2009.08.001
  37. Vallim TQD, 2013, CELL METAB, V17, P657, DOI 10.1016/j.cmet.2013.03.013
  38. Wahlstrom A, 2016, CELL METAB, V24, P41, DOI 10.1016/j.cmet.2016.05.005
  39. Xia JG, 2009, NUCLEIC ACIDS RES, V37, pW652, DOI 10.1093/nar/gkp356
  40. Zhang YQ, 2006, P NATL ACAD SCI USA, V103, P1006, DOI 10.1073/pnas.0506982103

Coleções
Artigos e Materiais de Revistas Científicas - FM/MGT
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/18
Artigos e Materiais de Revistas Científicas - LIM/35
Artigos e Materiais de Revistas Científicas - ODS/03