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https://observatorio.fm.usp.br/handle/OPI/34430
Title: | HERV-K and HERV-W transcriptional activity in myalgic encephalomyelitis/chronic fatigue syndrome |
Authors: | RODRIGUES, Lucas S.; NALI, Luiz H. da Silva; LEAL, Cibele O. D.; SABINO, Ester C.; LACERDA, Eliana M.; KINGDON, Caroline C.; NACUL, Luis; ROMANO, Camila M. |
Citation: | AUTOIMMUNITY HIGHLIGHTS, v.10, n.1, article ID UNSP 12, 5p, 2019 |
Abstract: | Background Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/MS) is an incapacitating chronic disease that dramatically compromise the life quality. The CFS/ME pathogenesis is multifactorial, and it is believed that immunological, metabolic and environmental factors play a role. It is well documented an increased activity of Human endogenous retroviruses (HERVs) from different families in autoimmune and neurological diseases, making these elements good candidates for biomarkers or even triggers for such diseases. Methods Here the expression of Endogenous retroviruses K and W (HERV-K and HERV-W) was determined in blood from moderately and severely affected ME/CFS patients through real time PCR. Results HERV-K was overexpressed only in moderately affected individuals but HERV-W showed no difference. Conclusions This is the first report about HERV-K differential expression in moderate ME/CFS. Although the relationship between HERVs and ME/CFS has yet to be proven, the observation of this phenomenon deserves further attention. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MIP Artigos e Materiais de Revistas Científicas - HC/IOT Artigos e Materiais de Revistas Científicas - IMT Artigos e Materiais de Revistas Científicas - LIM/46 Artigos e Materiais de Revistas Científicas - LIM/52 |
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art_RODRIGUES_HERVK_and_HERVW_transcriptional_activity_in_myalgic_encephalomyelitischronic_2019.PDF | publishedVersion (English) | 629.83 kB | Adobe PDF | View/Open |
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