LIM/13 - Laboratório de Genética e Cardiologia Molecular
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Understanding yellow fever-associated myocardial injury: an autopsy study
EBIOMEDICINE, v.96, article ID 104810, 15p, 2023
Background Yellow fever (YF) is a viral hemorrhagic fever, endemic in parts of South America and Africa. There is scarce evidence about the pathogenesis of the myocardial injury. The objective of this study is to evaluate the cardiac pathology in fatal cases of YF.Methods This retrospective autop...
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Survival of Heart Transplant Patients with Chagas' Disease Under Different Antiproliferative Immunosuppressive Regimens
ARQUIVOS BRASILEIROS DE CARDIOLOGIA, v.120, n.10, article ID e20230133, 8p, 2023
Background: Chagas' disease (CD) is an important cause of heart transplantation (HT). The main obstacle is Chagas' disease reactivation (CDR), usually associated to high doses of immunosuppressants. Previous studies have suggested an association of mycophenolate mofetil with increased CDR. Howeve...
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Before and after AlphaFold2: An overview of protein structure prediction
FRONTIERS IN BIOINFORMATICS, v.3, article ID 1120370, 8p, 2023
Three-dimensional protein structure is directly correlated with its function and its determination is critical to understanding biological processes and addressing human health and life science problems in general. Although new protein structures are experimentally obtained over time, there is st...
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Peripheral Artery Disease Diagnosed by Pulse Palpation as a Predictor of Coronary Artery Disease in Patients with Chronic Kidney Disease
JOURNAL OF CLINICAL MEDICINE, v.12, n.18, article ID 5882, 10p, 2023
There is a need of simple, inexpensive, and reliable noninvasive testing to predict coronary artery disease (CAD) in patients with chronic kidney disease (CKD), where the prevalence of cardiovascular (CV) events and death is elevated. We analyzed the association between peripheral artery disease ...
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Artificial Intelligence-Driven Screening System for Rapid Image-Based Classification of 12-Lead ECG Exams: A Promising Solution for Emergency Room Prioritization
IEEE ACCESS, v.11, p.121739-121752, 2023
The electrocardiogram (ECG) serves as a valuable diagnostic tool, providing crucial information about life-threatening cardiac conditions such as atrial fibrillation and myocardial infarction. A prompt and efficient assessment of ECG exams in environments such as Emergency Rooms (ERs) can signifi...
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Generation and validation of a classification model to diagnose familial hypercholesterolaemia in adults
ATHEROSCLEROSIS, v.383, article ID 117314, 8p, 2023
Background and aims: The early diagnosis of familial hypercholesterolaemia is associated with a significant reduction in cardiovascular disease (CVD) risk. While the recent use of statistical and machine learning algorithms has shown promising results in comparison with traditional clinical crite...
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Association between carotid intima-media thickness and cognitive decline differs by race
ALZHEIMERS & DEMENTIA, v.19, n.8, p.3528-3536, 2023
IntroductionCommon carotid intima-media thickness (cIMT) is a marker of subclinical atherosclerosis and is associated with cognitive decline. Although carotid atherosclerosis is more frequent in White than in Black participants, little is known whether race modifies the association between cIMT a...
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The Effect of Gene Editing by CRISPR-Cas9 of miR-21 and the Indirect Target MMP9 in Metastatic Prostate Cancer
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.24, n.19, article ID 14847, 15p, 2023
Prostate cancer (PCa) has a high prevalence and represents an important health problem, with an increased risk of metastasis. With the advance of CRISPR-Cas9 genome editing, new possibilities have been created for investigating PCa. The technique is effective in knockout oncogenes, reducing tumor...
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DEEP LEARNING BASED UV FACIAL IMAGING GENERATION
2023 IEEE 20TH INTERNATIONAL SYMPOSIUM ON BIOMEDICAL IMAGING, ISBI, 2023
Skin health has become a topic of interest in the recent years. To ensure a better diagnosis and treatment, the analysis of high-quality skin databases is crucial. In this regard, UV imaging is a valuable tool in detecting melanoma and other skin conditions. However, UV images present some challe...
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CARDIORENAL DYSFUNCTION IN MICE SUBMITTED TO AORTIC STENOSIS AND TREATED WITH SODIUM OXALATE
JOURNAL OF HYPERTENSION, v.41, suppl.3, p.E227-E227, 2023
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