LIM/45 - Laboratório de Neurologia Translacional

O Laboratório de Neurologia Translacional é ligado ao Departamento de Neurologia da Faculdade de Medicina da Universidade de São Paulo (FMUSP).

Linhas de pesquisa: regeneração do sistema nervoso central; terapia celular; neurologia experimental; neurocirurgia funcional; neuropatias neurocirúrgicas; tumores do sistema nervoso; base do crânio; más-formações craniofaciais; doença de Parkinson e distúrbios do sistema extrapiramidal.

Site oficial: http://limhc.fm.usp.br/portal/lim45-laboratorio-de-neurologia-translacional/

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Recent Submissions

  1. Electroconvulsive therapy for treating patients with agitation and related behavioral disorders due to dementia: a systematic review

    DEMENTIA & NEUROPSYCHOLOGIA, v.17, p.e20230007, 2023

    ABSTRACT Behavioral disturbances are clinically relevant in patients with dementia, and pharmacological regimens to mitigate these symptoms have provided limited results. Proven to be effective in several psychiatric conditions, electroconvulsive therapy is a potentially beneficial strategy for t...

  2. Brazilian experts' consensus on the treatment of infantile epileptic spasm syndrome in infants

    ARQUIVOS DE NEURO-PSIQUIATRIA, v.81, n.9, p.844-856, 2023

    Background Infantile epileptic spasms syndrome (IESS) is a rare but severe condition affecting children early and is usually secondary to an identifiable brain disorder. It is related to psychomotor deterioration in childhood and epilepsy in adult life. Treatment is challenging as infantile spasm...

  3. E.L., a modern-day Phineas Gage: Revisiting frontal lobe injury

    LANCET REGIONAL HEALTH-AMERICAS, v.14, article ID 100340, 17p, 2022

    Background How the prefrontal cortex (PFC) recovers its functionality following lesions remains a conundrum. Recent work has uncovered the importance of transient low-frequency oscillatory activity (LFO; < 4 Hz) for the recovery of an injured brain. We aimed to determine whether persistent cortic...

  4. Enhancing meningioma resection: a comprehensive study on the safety and effectiveness of Onyx™ presurgical embolization

    NEUROSURGICAL REVIEW, v.46, n.1, article ID 299, 11p, 2023

    Presurgical embolization (PE) has emerged as an interesting strategy to help turn brain tumor resection more amenable. This study aims to systematically review the safety and effectiveness of Onyx (TM) PE in meningioma resection. We followed Cochrane Collaboration and PRISMA for systematic review...

  5. Elevated salivary copper concentration in patients with Wilson's disease

    PARKINSONISM & RELATED DISORDERS, v.116, article ID 105893, 3p, 2023

  6. Doing More with Less on Intracranial Pressure Monitoring

    WORLD NEUROSURGERY, v.178, p.93-95, 2023

    BACKGROUND: Intracranial pressure (ICP) management based on predetermined thresholds is not accurate in light of recent research on cerebrovascular physiology. Interpersonal and intrapersonal variations will lead ICP elevations to reach individualized thresholds for intracranial compliance impair...

  7. Is transcranial direct current stimulation (tDCS) effective to improve cognition and functionality after severe traumatic brain injury? A perspective article and hypothesis

    FRONTIERS IN HUMAN NEUROSCIENCE, v.17, article ID 1162854, 8p, 2023

    Severe traumatic brain injury (sTBI) is an important cause of disability and mortality and affects people of all ages. Current scientific evidence indicates that motor dysfunction and cognitive impairment are the main limiting factors in patients with sTBI. Transcranial direct current stimulation...

  8. The (in)visible Brazilians: A perspective review on the need for brain health and dementia research with Brazilian immigrants in the United States

    ALZHEIMERS & DEMENTIA-TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS, v.9, n.3, article ID e12425, 13p, 2023

    Introduction: The Brazilian population in the United States (U.S.), a Latinx subgroup, is rapidly growing and aging but remains underrepresented in U.S. health research. In addition to group-specific genetic and environmental risks, Brazilian immigrants and their offspring in the U.S. likely have...

  9. The (in)visible Brazilians: A perspective review on the need for brain health and dementia research with Brazilian immigrants in the United States ( vol 9, e12425, 2023)

    ALZHEIMERS & DEMENTIA-TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS, v.9, n.4, article ID e12433, 1p, 2023

  10. Diagnostic Performance of an Eye-Tracking Assisted Visual Inference Language Test in the Assessment of Cognitive Decline due to Alzheimer's Disease

    JOURNAL OF ALZHEIMERS DISEASE, v.94, n.3, p.1105-1119, 2023

    Background: The assessment of language changes associated with visual search impairment can be an important diagnostic tool in the Alzheimer's disease (AD) continuum. Objective: Investigate the performance of an eye-tracking assisted visual inference language task in differentiating subjects with...