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DC Field | Value | Language |
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dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | - |
dc.contributor.author | ZERATI, Marcelo | - |
dc.contributor.author | LEITE, Katia R. M. | - |
dc.contributor.author | PONTES-JUNIOR, Jose | - |
dc.contributor.author | SEGRE, Cesar Camara | - |
dc.contributor.author | REIS, Sabrina Thalita | - |
dc.contributor.author | SROUGI, Miguel | - |
dc.contributor.author | DALL'OGLIO, Marcos Francisco | - |
dc.date.accessioned | 2014-01-28T22:16:05Z | - |
dc.date.available | 2014-01-28T22:16:05Z | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | INTERNATIONAL BRAZ J UROL, v.39, n.4, p.484-492, 2013 | - |
dc.identifier.issn | 1677-5538 | - |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/3861 | - |
dc.description.abstract | Introduction: The knowledge about the molecular biology of clear cell renal cell carcinoma (ccRCC) is evolving, and Carbonic Anhydrase type IX (CA-IX) has emerged as a potential prognostic marker in this challenging disease. However, most of the literature about CA-IX on ccRCC comes from series on metastatic cancer, with a lack of series on non-metastatic cancer. The objective is to evaluate the expression of CA-IX in a cohort of non-metastatic ccRCC, correlating with 1) overall survival, and 2) with established prognostic parameters (T stage, tumor size, Fuhrman nuclear grade, microvascular invasion and peri-renal fat invasion). Materials and Methods: This is a retrospective cohort study. We evaluated 95 patients with non-metastatic clear cell renal cell carcinoma, as to the expression of CA-IX. The analyzed parameters where: overall survival (OS), TNM stage, tumor size (TS), Fuhrman nuclear grade (FNG), microvascular invasion (MVI), peri-renal fat invasion (PFI). We utilized a custom built tissue microarray, and the immunoexpression was digitally quantified using the Photoshop (R) software. Results: The mean follow-up time was 7.9 years (range 1.9 to 19.5 years). The analysis of CA-IX expression against the selected prognostic parameters showed no correlation. The results are as follows: Overall survival (p = 0.790); T stage (p = 0.179); tumor size (p = 0.143); grouped Fuhrman nuclear grade (p = 0.598); microvascular invasion (p = 0.685), and peri-renal fat invasion (p = 0.104). Conclusion: Carbonic anhydrase type IX expression does not correlate with overall survival and conventional prognostic parameters in non-metastatic clear cell renal cell carcinoma. | - |
dc.description.sponsorship | FAPESP (State of Sao Paulo Agency for Research Support) [2008/52908-8] | - |
dc.language.iso | eng | - |
dc.publisher | BRAZILIAN SOC UROL | - |
dc.relation.ispartof | International Braz J Urol | - |
dc.rights | openAccess | - |
dc.subject | Carcinoma | - |
dc.subject | Renal Cell | - |
dc.subject | Tissue Array Analysis | - |
dc.subject | Immunohistochemistry | - |
dc.subject | Carbonic Anhydrases | - |
dc.subject.other | inducible factor 1-alpha | - |
dc.subject.other | image-analysis | - |
dc.subject.other | independent predictor | - |
dc.subject.other | molecular markers | - |
dc.subject.other | prognostic value | - |
dc.subject.other | tumor specimens | - |
dc.subject.other | adobe-photoshop | - |
dc.subject.other | breast-cancer | - |
dc.subject.other | genetic-basis | - |
dc.subject.other | expression | - |
dc.title | Carbonic Anhydrase IX is Not a Predictor of Outcomes in Non-Metastatic Clear Cell Renal Cell Carcinoma - A Digital Analysis of Tissue Microarray | - |
dc.type | article | - |
dc.rights.holder | Copyright BRAZILIAN SOC UROL | - |
dc.identifier.doi | 10.1590/S1677-5538.IBJU.2013.04.05 | - |
dc.identifier.pmid | 24054396 | - |
dc.subject.wos | Urology & Nephrology | - |
dc.type.category | original article | - |
dc.type.version | publishedVersion | - |
hcfmusp.description.beginpage | 484 | - |
hcfmusp.description.endpage | 492 | - |
hcfmusp.description.issue | 4 | - |
hcfmusp.description.volume | 39 | - |
hcfmusp.origem | WOS | - |
hcfmusp.origem.id | WOS:000327879200005 | - |
hcfmusp.origem.id | 2-s2.0-84885340191 | - |
hcfmusp.origem.id | SCIELO:S1677-55382013000400484 | - |
hcfmusp.publisher.city | RIO DE JANEIRO | - |
hcfmusp.publisher.country | BRAZIL | - |
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dc.description.index | MEDLINE | - |
hcfmusp.remissive.sponsorship | FAPESP | - |
hcfmusp.citation.scopus | 9 | - |
hcfmusp.scopus.lastupdate | 2024-04-12 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MCG Artigos e Materiais de Revistas Científicas - HC/ICESP Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - LIM/55 Artigos e Materiais de Revistas Científicas - ODS/03 |
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