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https://observatorio.fm.usp.br/handle/OPI/3887
Title: | Vaccine-Induced Gag-Specific T Cells Are Associated With Reduced Viremia After HIV-1 Infection |
Authors: | JANES, Holly; FRIEDRICH, David P.; KRAMBRINK, Amy; SMITH, Rebecca J.; KALLAS, Esper G.; HORTON, Helen; CASIMIRO, Danilo R.; CARRINGTON, Mary; GERAGHTY, Daniel E.; GILBERT, Peter B.; MCELRATH, M. Juliana; FRAHM, Nicole |
Citation: | JOURNAL OF INFECTIOUS DISEASES, v.208, n.8, p.1231-1239, 2013 |
Abstract: | The contribution of host T-cell immunity and HLA class I alleles to the control of human immunodeficiency virus (HIV-1) replication in natural infection is widely recognized. We assessed whether vaccine-induced T-cell immunity, or expression of certain HLA alleles, impacted HIV-1 control after infection in the Step MRKAd5/HIV-1 gag/pol/nef study. Vaccine-induced T cells were associated with reduced plasma viremia, with subjects targeting >= 3 gag peptides presenting with half-log lower mean viral loads than subjects without Gag responses. This effect was stronger in participants infected proximal to vaccination and was independent of our observed association of HLA-B(star)27, -B(star)57 and -B(star)58:01 alleles with lower HIV-1 viremia. These findings support the ability of vaccine-induced T-cell responses to influence postinfection outcome and provide a rationale for the generation of T-cell responses by vaccination to reduce viremia if protection from acquisition is not achieved. Clinical trials identifier: NCT00095576. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MCM Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - LIM/60 Artigos e Materiais de Revistas Científicas - ODS/03 |
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