Frequency of Leishmania spp. infection among HIV-infected patients living in an urban area in Brazil: a cross-sectional study

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art_CUNHA_Frequency_of_Leishmania_spp_infection_among_HIVinfected_patients_2020.PDF (584.4 KB)
Citações na Scopus
6
Tipo de produção
article
Data de publicação
2020
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
BMC
Autores
CUNHA, M. A.
LAGO, M. M.
IBANES, A. S.
OUKI, L. M.
SIMOES NETO, E. A.
FONSECA, F. F.
SILVA, M. A. L.
Citação
BMC INFECTIOUS DISEASES, v.20, n.1, article ID 885, 10p, 2020
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
BackgroundThere is little information about the frequency of Leishmania infection in asymptomatic people living with HIV (PLWH) and about the performance of laboratory diagnostic methods in coinfected patients in Latin America. The main objective of this study is to evaluate the frequency of Leishmania spp. infection in HIV-infected patients living in an urban area in Brazil.MethodsTo detect Leishmania infection, diagnostic tests were performed to detect anti-Leishmania antibodies (ELISA using Leptomonas seymouri antigens; ELISA using rK39 antigens; ELISA using rK28 antigens; indirect fluorescent-antibody test (IFAT); direct agglutination test (DAT)) and Leishmania DNA (polymerase chain reaction (PCR) with the target genes kDNA and ITS-1).ResultsThe frequency of at least one positive test was 15%. For ELISA using Leptomonas antigens and IFAT, there was an association between CD4+ T lymphocyte counts and test positivity, with a higher positivity of these tests in more immunosuppressed patients (CD4+ T cell count <200/mm(3)).ConclusionsAccording to our data, there was a high prevalence of Leishmania spp. infections in this population living with HIV. Although there is the possibility of cross-reaction, some tests that are considered highly specific for the diagnosis of Leishmania infection were positive. There was also an association between the positivity of some tests studied and lower values of CD4+ T lymphocytes.
Palavras-chave
Leishmaniasis, Acquired immunodeficiency syndrome, Diagnosis, Prevalence
URI
https://observatorio.fm.usp.br/handle/OPI/39236
Referências
  1. Alvar J, 1997, CLIN MICROBIOL REV, V10, P298, DOI 10.1128/CMR.10.2.298
  2. Alvar J, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0035671
  3. [Anonymous], 2014, VISC LEISHM SURV CON
  4. [Anonymous], 2011, LEISHM HIST EP TREND, P7
  5. [Anonymous], 2018, TECHN MAN DIAGN HIV
  6. Aransay AM, 2000, APPL ENVIRON MICROB, V66, P1933, DOI 10.1128/AEM.66.5.1933-1938.2000
  7. Badaro R, 1996, J INFECT DIS, V173, P758, DOI 10.1093/infdis/173.3.758
  8. Barbosaor WL, 2015, AM J TROP MED HYG, V93, P967, DOI 10.4269/ajtmh.14-0798
  9. da Silva MRB, 2018, PARASITOL RES, V117, P419, DOI 10.1007/s00436-017-5716-3
  10. Boelaert M, 2004, AM J TROP MED HYG, V70, P72, DOI 10.4269/ajtmh.2004.70.72
  11. Braz RFS, 2002, AM J TROP MED HYG, V67, P344, DOI 10.4269/ajtmh.2002.67.344
  12. Carranza-Tamayo CO, 2009, T ROY SOC TROP MED H, V103, P743, DOI 10.1016/j.trstmh.2009.01.014
  13. Cota GF, 2011, PLOS NEGLECT TROP D, V5, DOI 10.1371/journal.pntd.0001153
  14. Cota GF, 2013, AM J TROP MED HYG, V89, P570, DOI 10.4269/ajtmh.13-0239
  15. Cota GF, 2012, PLOS NEGLECT TROP D, V6, DOI 10.1371/journal.pntd.0001665
  16. Coura-Vital W, 2014, PLOS NEGLECT TROP D, V8, DOI 10.1371/journal.pntd.0003374
  17. de Paiva-Cavalcanti M, 2015, CELL BIOSCI, V5, DOI 10.1186/s13578-015-0021-2
  18. de Ruiter CM, 2014, J CLIN MICROBIOL, V52, P3147, DOI 10.1128/JCM.00372-14
  19. Diro E, 2015, PLOS NEGLECT TROP D, V9, DOI 10.1371/journal.pntd.0003738
  20. Echchakery M, 2018, PARASITOL RES, V117, P1237, DOI 10.1007/s00436-018-5805-y
  21. ELHARITH A, 1988, J CLIN MICROBIOL, V26, P1321, DOI 10.1128/JCM.26.7.1321-1325.1988
  22. Ferreira GR, 2018, AM J TROP MED HYG, V98, P126, DOI 10.4269/ajtmh.16-0883
  23. Ferreira LR, 2014, ACTA TROP, V131, P41, DOI 10.1016/j.actatropica.2013.11.010
  24. Garrote JI, 2004, AM J TROP MED HYG, V71, P403, DOI 10.4269/ajtmh.2004.71.403
  25. GRADONI L, 1993, T ROY SOC TROP MED H, V87, P94, DOI 10.1016/0035-9203(93)90441-R
  26. Guimaraes M C, 1974, Rev Inst Med Trop Sao Paulo, V16, P145
  27. Hirve S, 2016, PLOS NEGLECT TROP D, V10, DOI 10.1371/journal.pntd.0004896
  28. Jarvis JN, 2013, CURR OPIN INFECT DIS, V26, P1, DOI 10.1097/QCO.0b013e32835c2198
  29. Kesper N, 2017, REV INST MED TROP SP, V59, DOI [10.1590/S1678-9946201759001, 10.1590/s1678-9946201759001]
  30. Elmahallawy EK, 2014, J INFECT DEV COUNTR, V8, P961, DOI 10.3855/jidc.4310
  31. Lachaud L, 2000, J CLIN MICROBIOL, V38, P236
  32. Lindoso JA, 2014, PLOS NEGLECT TROP D, V8, DOI 10.1371/journal.pntd.0003136
  33. Ministry of Health, 2016, EPIDEMIOLOGICAL B, P14
  34. Mock DJ, 2012, PLOS PATHOG, V8, DOI 10.1371/journal.ppat.1002635
  35. Morales MA, 2002, J INFECT DIS, V185, P1533, DOI 10.1086/340219
  36. Moreno EC, 2006, REV SOC BRAS MED TRO, V39, P421, DOI 10.1590/S0037-86822006000500001
  37. Moreno EC, 2009, PLOS NEGLECT TROP D, V3, DOI 10.1371/journal.pntd.0000536
  38. Mukhtar M, 2015, T ROY SOC TROP MED H, V109, P594, DOI 10.1093/trstmh/trv060
  39. Murray HW, 2005, LANCET, V366, P1561, DOI 10.1016/S0140-6736(05)67629-5
  40. Nascimento ET, 2011, T ROY SOC TROP MED H, V105, P298, DOI 10.1016/j.trstmh.2011.01.006
  41. Nascimento Maria do Desterro Soares Brandão, 2005, Cad. Saúde Pública, V21, P1801, DOI 10.1590/S0102-311X2005000600028
  42. Orsini M, 2012, T ROY SOC TROP MED H, V106, P283, DOI 10.1016/j.trstmh.2012.01.008
  43. Pasquau F, 2005, EUR J CLIN MICROBIOL, V24, P411, DOI 10.1007/s10096-005-1342-6
  44. Patil RR, 2012, HUM VACC IMMUNOTHER, V8, P725, DOI 10.4161/hv.19542
  45. de Albuquerque LCP, 2014, REV SOC BRAS MED TRO, V47, P38, DOI 10.1590/0037-8682-0180-2013
  46. Peruhype-Magalhaes V, 2012, MEM I OSWALDO CRUZ, V107, P951, DOI 10.1590/S0074-02762012000700019
  47. Pizzuto M, 2001, J CLIN MICROBIOL, V39, P357, DOI 10.1128/JCM.39.1.357-361.2001
  48. Pourabbas B, 2013, AM J TROP MED HYG, V88, P868, DOI 10.4269/ajtmh.12-0440
  49. Rangel O, 2013, B EPIDEMIOL PAUL, V10, P3
  50. Schonian G, 2003, DIAGN MICR INFEC DIS, V47, P349, DOI 10.1016/S0732-8893(03)00093-2
  51. Umezawa ES, 1996, J CLIN MICROBIOL, V34, P2143, DOI 10.1128/JCM.34.9.2143-2147.1996
  52. Vaish M, 2012, CLIN MICROBIOL INFEC, V18, P81, DOI 10.1111/j.1469-0691.2011.03540.x
  53. van Griensven J, 2014, PLOS NEGLECT TROP D, V8, DOI 10.1371/journal.pntd.0003023
  54. van Griensven J, 2012, INFECT DIS CLIN N AM, V26, P309, DOI 10.1016/j.idc.2012.03.005
  55. Viana LD, 2008, T ROY SOC TROP MED H, V102, P548, DOI 10.1016/j.trstmh.2008.02.007
  56. Werneck GL, 2014, REV SAUDE PUBL, V48, P851, DOI 10.1590/S0034-8910.2014048005615
  57. 2019, WHO TECH REP SER, V1016, P1

Coleções
Artigos e Materiais de Revistas Científicas - FM/MIP
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - IMT
Artigos e Materiais de Revistas Científicas - LIM/38
Artigos e Materiais de Revistas Científicas - LIM/49
Artigos e Materiais de Revistas Científicas - ODS/03