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https://observatorio.fm.usp.br/handle/OPI/4029
Title: | Self-collection for high-risk HPV detection in Brazilian women using the caFeHPV (TM) test |
Authors: | LORENZI, Adriana Tarla; FREGNANI, Jose Humberto T. G.; POSSATI-RESENDE, Julio Cesar; NETO, Cristovam Scapulatempo; VILLA, Luisa Lina; LONGATTO-FILHO, Adhemar |
Citation: | GYNECOLOGIC ONCOLOGY, v.131, n.1, p.131-134, 2013 |
Abstract: | Objective. Cervical cancer is the second most common cancer among Brazilian women. High-risk human papillomavirus (hr-HPV) persistence is the primary cause of cervical neoplasia. Early detection of hr-HPV is important for identifying women at risk for developing cervical lesions. Approximately 85% of new cases of cervical cancer worldwide and 50% of the total cervical cancer deaths occurred in developing countries. Here, a new methodology to support a cervical cancer screening program was evaluated in women from various Brazilian regions. Methods. Two thousand women aged 18-77 years were enrolled in an opportunistic cervical cancer screening program and were randomized into self-vaginal or health professional-guided cervical sampling groups. The Qiagen careHPV (TM) test was performed on all samples. Pap tests were performed on all women using liquid-based cytology. Results. Positive hr-HPV results were obtained in 12.3% (245/2000) of women; similar rates were observed in self- or health professional-collected samples. Eighty-nine percent (1719/2000) of cervical cytologies classified as normal were negative to hr-HPV. Among the cytological samples, 36.6% classified as ASC-US + were positive to hr-HPV, 78.8% were LSIL and 75.0% were HSIL. Conclusions. Self-sampled and health professional-sampled vaginal/cervical specimens did not differ in their rates of detection of hr-HPV. Therefore, HPV DNA testing in self-sampled vaginal cells is an alternative to primary screening in low-resource settings. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MDR Artigos e Materiais de Revistas Científicas - LIM/14 Artigos e Materiais de Revistas Científicas - LIM/24 Artigos e Materiais de Revistas Científicas - ODS/03 |
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