Please use this identifier to cite or link to this item:
https://observatorio.fm.usp.br/handle/OPI/4123| Title: | Convergence of two major pathophysiologic mechanisms in nasal polyposis: immune response to Staphylococcus aureus and airway remodeling |
| Authors: | PEZATO, Rogerio; BALSALOBRE, Leonardo; LIMA, Milena; BEZERRA, Thiago F. P.; VOEGELS, Richard L.; GREGORIO, Luis Carlos; STAMM, Aldo Cassol; ZELE, Thibaut van |
| Citation: | JOURNAL OF OTOLARYNGOLOGY-HEAD & NECK SURGERY, v.42, article ID 27, 5p, 2013 |
| Abstract: | This review is addressed two pathophysiologic mechanisms implicated in the pathogenesis of nasal polyposis: the unique remodeling process found in nasal polyp tissue and the immune response of patients with nasal polyposis to Staphylococcus aureus. These two theories converge to the same direction in different aspects, including decreased extracellular matrix production, impaired T regulation and favoring of a Th2 immune response. In patients with nasal polyposis, an exaggerated immune response to Staphylococcus aureus may aggravate the airway remodeling process. |
| Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MOF Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - LIM/32 |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| art_BEZERRA_Convergence_of_two_major_pathophysiologic_mechanisms_in_nasal_2013.PDF | publishedVersion (English) | 258.87 kB | Adobe PDF |  View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.