Assessment of avidity related to IgG subclasses in SARS-CoV-2 Brazilian infected patients
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Citações na Scopus
39
Tipo de produção
article
Data de publicação
2021
Título da Revista
ISSN da Revista
Título do Volume
Editora
NATURE PORTFOLIO
Autores
MOURA, Andrew D.
COSTA, Hernan H. M. da
CORREA, Victor A.
LIMA, Ana K. de S.
GASPARI, Elizabeth De
HONG, Marisa A.
CUNHA-JUNIOR, Jair P.
PRUDENCIO, Carlos R.
Citação
SCIENTIFIC REPORTS, v.11, n.1, article ID 17642, 13p, 2021
Resumo
SARS-CoV-2 is considered a global emergency, resulting in an exacerbated crisis in the health public in the world. Although there are advances in vaccine development, it is still limited for many countries. On the other hand, an immunological response that mediates protective immunity or indicates that predict disease outcome in SARS-CoV-2 infection remains undefined. This work aimed to assess the antibody levels, avidity, and subclasses of IgG to RBD protein, in symptomatic patients with severe and mild forms of COVID-19 in Brazil using an adapted in-house RBD-IgG ELISA. The RBD IgG-ELISA showed 100% of specificity and 94.3% of sensibility on detecting antibodies in the sera of hospitalized patients. Patients who presented severe COVID-19 had higher anti-RBD IgG levels compared to patients with mild disease. Additionally, most patients analyzed displayed low antibody avidity, with 64.4% of the samples of patients who recovered from the disease and 84.6% of those who died in this avidity range. Our data also reveals an increase of IgG1 and IgG3 levels since the 8th day after symptoms onset, while IgG4 levels maintained less detectable during the study period. Surprisingly, patients who died during 8-14 and 15-21 days also showed higher anti-RBD IgG4 levels in comparison with the recovered (P < 0.05), suggesting that some life-threatening patients can elicit IgG4 to RBD antibody response in the first weeks of symptoms onset. Our findings constitute the effort to clarify IgG antibodies' kinetics, avidity, and subclasses against SARS-CoV-2 RBD in symptomatic patients with COVID-19 in Brazil, highlighting the importance of IgG antibody avidity in association with IgG4 detection as tool laboratory in the follow-up of hospitalized patients with more significant potential for life-threatening.
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Referências
- Amanat F, 2020, NAT MED, V26, P1033, DOI 10.1038/s41591-020-0913-5
- Amanat F, 2020, IMMUNITY, V52, P583, DOI 10.1016/j.immuni.2020.03.007
- Andersen KG, 2020, NAT MED, V26, P450, DOI 10.1038/s41591-020-0820-9
- Azkur AK, 2020, ALLERGY, V75, P1564, DOI 10.1111/all.14364
- Bachmann MF, 1997, SCIENCE, V276, P2024, DOI 10.1126/science.276.5321.2024
- Bauer G, 2021, INT J INFECT DIS, V106, P61, DOI 10.1016/j.ijid.2021.01.061
- Benner SE, 2020, J INFECT DIS, V222, P1974, DOI 10.1093/infdis/jiaa581
- Bilich T, 2021, SCI TRANSL MED, V13, DOI 10.1126/scitranslmed.abf7517
- BOPPANA SB, 1995, J INFECT DIS, V171, P1115, DOI 10.1093/infdis/171.5.1115
- Cassaniti I, 2020, J MED VIROL, V92, P1724, DOI 10.1002/jmv.25800
- Castro R, 2020, BRAZ J INFECT DIS, V24, P180, DOI 10.1016/j.bjid.2020.04.003
- Cavacini LA, 2003, AIDS RES HUM RETROV, V19, P785, DOI 10.1089/088922203769232584
- Chan KH, 2007, CLIN VACCINE IMMUNOL, V14, P1433, DOI 10.1128/CVI.00056-07
- Chen NS, 2020, LANCET, V395, P507, DOI 10.1016/S0140-6736(20)30211-7
- De Azevedo M. S. P., 2021, JMIR PUBLIC HLTH SUR
- Dobano C, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-10195-z
- Eisen HN, 2014, CANCER IMMUNOL RES, V2, P381, DOI 10.1158/2326-6066.CIR-14-0029
- Engin AB, 2020, ENVIRON TOXICOL PHAR, V78, DOI 10.1016/j.etap.2020.103411
- Felipe Rocha da Silva S, RES SQUARE, DOI [10.21203/rs.3.rs-402349/v2, DOI 10.21203/RS.3.RS-402349/V2]
- Delgado MF, 2009, NAT MED, V15, P34, DOI 10.1038/nm.1894
- Frasca D, 2017, CLIN EXP IMMUNOL, V187, P64, DOI 10.1111/cei.12824
- Frasca D, 2013, IMMUN AGEING, V10, DOI 10.1186/1742-4933-10-14
- Gaspar EB., 2021, HUM VACC IMMUNOTHER, DOI [10.1080/21645515.2021.1920272, DOI 10.1080/21645515.2021.1920272]
- Greiner M, 1996, J IMMUNOL METHODS, V191, P93, DOI 10.1016/0022-1759(96)00013-0
- Guan W.-J., 2002, CLIN CHARACTERISTICS
- Guo L, 2020, CLIN INFECT DIS, V71, P778, DOI 10.1093/cid/ciaa310
- Hsueh PR, 2004, CLIN MICROBIOL INFEC, V10, P1062, DOI 10.1111/j.1469-0691.2004.01009.x
- Huynh A., 2020, DEV SEROLOGICAL ASSA, V2009
- Iwasaki A, 2020, NAT REV IMMUNOL, V20, P339, DOI 10.1038/s41577-020-0321-6
- Jiang SB, 2020, TRENDS IMMUNOL, V41, P545, DOI 10.1016/j.it.2020.04.008
- JUNKER AK, 1994, J MED VIROL, V43, P119, DOI 10.1002/jmv.1890430204
- Kaneko M, 2017, J INFECT CHEMOTHER, V23, P173, DOI 10.1016/j.jiac.2016.12.001
- KAWANO Y, 1994, J IMMUNOL, V153, P4948
- Kellam P, 2020, J GEN VIROL, V101, P791, DOI 10.1099/jgv.0.001439
- Khatri I, 2020, FRONT IMMUNOL, V11, DOI 10.3389/fimmu.2020.570018
- Kontio M, 2012, J INFECT DIS, V206, P1542, DOI 10.1093/infdis/jis568
- Krammer F, 2020, NATURE, V586, P516, DOI 10.1038/s41586-020-2798-3
- Kweon OJ, 2020, PLOS ONE, V15, DOI 10.1371/journal.pone.0240395
- Lai L, 2007, VIROLOGY, V369, P153, DOI 10.1016/j.virol.2007.07.017
- Lazzarotto T, 2000, VIRAL IMMUNOL, V13, P137, DOI 10.1089/vim.2000.13.137
- Liu XM, 2020, EMERG MICROBES INFEC, V9, P1269, DOI 10.1080/22221751.2020.1773324
- Long QX, 2020, NAT MED, V26, P1200, DOI 10.1038/s41591-020-0965-6
- Long QX, 2020, NAT MED, V26, P845, DOI 10.1038/s41591-020-0897-1
- MARTIN KA, 1994, J INFECT DIS, V170, P991, DOI 10.1093/infdis/170.4.991
- Mazzini L, 2021, J IMMUNOL METHODS, V489, DOI 10.1016/j.jim.2020.112937
- Menezes P. D. L., 2020, BRAZIL IS PROJECTED, DOI [10.1101/2020.04.28.20083675, DOI 10.1101/2020.04.28.20083675]
- Miot Hélio Amante, 2017, J. vasc. bras., V16, P88, DOI 10.1590/1677-5449.041117
- Nagao-Dias AT, 2007, BRAZ J INFECT DIS, V11, P215, DOI 10.1590/S1413-86702007000200009
- OMS, 2020, WHO COVID 19 WEEKL E, V1, P4
- Padoan A, 2020, CLIN CHEM LAB MED, V58, P1081, DOI 10.1515/cclm-2020-0443
- Pegu P, 2013, J VIROL, V87, P1708, DOI 10.1128/JVI.02544-12
- Nguyen-Contant P, 2020, MBIO, V11, DOI 10.1128/mBio.01991-20
- Poland GA, 2020, LANCET, V396, P1595, DOI 10.1016/S0140-6736(20)32137-1
- PULLEN GR, 1986, J IMMUNOL METHODS, V86, P83, DOI 10.1016/0022-1759(86)90268-1
- Puschnik A, 2013, PLOS NEGLECT TROP D, V7, DOI 10.1371/journal.pntd.0002274
- Rai P, 2021, APPL MICROBIOL BIOT, V105, P441, DOI 10.1007/s00253-020-11061-5
- Rebello CJ, 2020, INT J OBESITY, V44, P1810, DOI 10.1038/s41366-020-0640-5
- Ribas RM, 2020, TRAVEL MED INFECT DI, V37, DOI 10.1016/j.tmaid.2020.101675
- Santana SS, 2012, IMMUNOL LETT, V143, P193, DOI 10.1016/j.imlet.2012.02.008
- Satoguina JS, 2005, J IMMUNOL, V174, P4718, DOI 10.4049/jimmunol.174.8.4718
- Scohy A, 2020, J CLIN VIROL, V129, DOI 10.1016/j.jcv.2020.104455
- Seo S, 2009, KOREAN J LAB MED, V29, P557, DOI 10.3343/kjlm.2009.29.6.557
- Shih HI, 2020, BIOMED J, V43, P341, DOI 10.1016/j.bj.2020.05.021
- Siracusano G, 2020, FRONT IMMUNOL, V11, DOI 10.3389/fimmu.2020.01049
- Stadlbauer Daniel, 2020, Curr Protoc Microbiol, V57, pe100, DOI 10.1002/cpmc.100
- Stromer A., 2020, DIAGNOSTIC ACCURACY, V2015
- Suthar MS, 2020, CELL REP MED, V1, DOI [10.1016/j.xcrm.2020.100040, 10.1101/2020.05.03.20084442]
- Tai WB, 2020, CELL MOL IMMUNOL, V17, P613, DOI 10.1038/s41423-020-0400-4
- Valdivia A, 2021, J MED VIROL, V93, P1141, DOI 10.1002/jmv.26344
- Walls AC, 2020, CELL, V181, P281, DOI [10.1016/j.cell.2020.02.058, 10.1016/j.cell.2020.11.032]
- Walsh EE, 2020, NEW ENGL J MED, V383, P2439, DOI 10.1056/NEJMoa2027906
- Wang P, 2020, J VIROL METHODS, V283, DOI 10.1016/j.jviromet.2020.113919
- Ward S, 2020, J ALLERGY CLIN IMMUN, V146, P23, DOI 10.1016/j.jaci.2020.05.012
- Wolf J, 2020, CLIN CHIM ACTA, V511, P352, DOI 10.1016/j.cca.2020.10.035
- Wolfel R, 2020, NATURE, V588, pE35, DOI [10.1159/000505601, 10.1038/s41586-020-2984-3, 10.1038/s41586-020-2196-x]
- World Health Organization, 2020, LAB BIOS GUID REL CO
- Yang HS, 2020, CLIN CHIM ACTA, V509, P117, DOI 10.1016/j.cca.2020.06.004
- Zhang JJ, 2021, ALLERGY, V76, P533, DOI [10.1111/all.14238, 10.1111/all.14496]
- Zhang YJ, 2021, LANCET INFECT DIS, V21, P181, DOI 10.1016/S1473-3099(20)30843-4
- Zhao JJ, 2020, CLIN INFECT DIS, V71, P2027, DOI 10.1093/cid/ciaa344
- Zheng J, 2020, INT J BIOL SCI, V16, P1678, DOI 10.7150/ijbs.45053