Long-term decrease in immediate early gene expression after electroconvulsive seizures

Show simple item record

dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.author CALAIS, Julien Braga
VALVASSORI, Samira S.
RESENDE, Wilson R.
FEIER, Gustavo
ATHIE, Maria Carolina Pedro
RIBEIRO, Sidarta
GATTAZ, Wagner Farid FMUSP-HC
QUEVEDO, Joao
OJOPI, Elida Benquique
dc.date.issued 2013
dc.identifier.citation JOURNAL OF NEURAL TRANSMISSION, v.120, n.2, p.259-266, 2013
dc.identifier.issn 0300-9564
dc.identifier.uri http://observatorio.fm.usp.br/handle/OPI/4230
dc.description.abstract Electroconvulsive therapy (ECT) is a well-established psychiatric treatment for severe depression. Despite its clinical utility, post-ECT memory deficits are a common side effect. Neuronal plasticity and memory consolidation are intimately related to the expression of immediate early genes (IEG), such as Egr1, Fos and Arc. Changes in IEG activation have been postulated to underlie long-term neuronal adaptations following electroconvulsive seizures (ECS), an animal model of ECT. To test this hypothesis, we used real-time PCR to examine the effect of acute and chronic ECS (8 sessions, one every other day) on the long-term (> 24 h) expression of IEG Egr1, Fos and Arc in the hippocampus, a brain region implicated both in the pathophysiology of depression as well as in memory function. We observed a transient increase in Egr1 and Fos expression immediately after ECS, followed by a long-term decrease of IEG levels after both acute and chronic ECS. A separate group of animals, submitted to the same chronic ECS protocol and then subjected to open field or passive avoidance tasks, confirmed robust memory deficits 2 weeks after the last chronic ECS. The possible role of IEG downregulation on long-term learning deficits observed following ECS are discussed.
dc.description.sponsorship · National Council of Technological and Scientific Development (CNPq)
· Coordination for the Improvement of Higher Level Personnel (Capes)
· Associacao Beneficente Alzira Denise Hertzog da Silva (ABADHS) [FMUSP-HC/LIM-27]
· State of Sao Paulo Research Foundation (FAPESP)
dc.language.iso eng
dc.publisher SPRINGER WIEN
dc.relation.ispartof Journal of Neural Transmission
dc.rights restrictedAccess
dc.subject Arc; Egr1; Electroconvulsive seizures; Fos
dc.subject.other rat-brain; c-fos; transcription factors; messenger-rna; synaptic plasticity; memory; therapy; hippocampus; induction; potentiation
dc.title Long-term decrease in immediate early gene expression after electroconvulsive seizures
dc.type article
dc.rights.holder Copyright SPRINGER WIEN
dc.description.group LIM/27
dc.identifier.doi 10.1007/s00702-012-0861-4
dc.identifier.pmid 22875635
dc.type.category original article
dc.type.version publishedVersion
hcfmusp.author GATTAZ, Wagner Farid:FM:MPS
hcfmusp.author.external · CALAIS, Julien Braga:Univ Sao Paulo, Fac Med, Lab Neurociencias LIM 27, Hosp Clin,Inst Psiquiatria, Sao Paulo, Brazil
· VALVASSORI, Samira S.:Univ So Santa Catarina, Ctr Excellence Appl Neurosci Santa Catarina NENAS, Postgrad Program Hlth Sci, Hlth Sci Unit, BR-88806000 Criciuma, SC, Brazil
· RESENDE, Wilson R.:Univ So Santa Catarina, Ctr Excellence Appl Neurosci Santa Catarina NENAS, Postgrad Program Hlth Sci, Hlth Sci Unit, BR-88806000 Criciuma, SC, Brazil
· FEIER, Gustavo:Univ So Santa Catarina, Ctr Excellence Appl Neurosci Santa Catarina NENAS, Postgrad Program Hlth Sci, Hlth Sci Unit, BR-88806000 Criciuma, SC, Brazil
· ATHIE, Maria Carolina Pedro:Univ Sao Paulo, Fac Med, Lab Neurociencias LIM 27, Hosp Clin,Inst Psiquiatria, Sao Paulo, Brazil
· RIBEIRO, Sidarta:Edmond & Lily Safra Int Inst Neurosci Natal ELS I, Natal, RN, Brazil; Fed Univ Rio Grande Norte UFRN, Inst Nacl Ciencia & Tecnol Interfaces Cerebo Maqu, Natal, RN, Brazil
· QUEVEDO, Joao:Univ So Santa Catarina, Ctr Excellence Appl Neurosci Santa Catarina NENAS, Postgrad Program Hlth Sci, Hlth Sci Unit, BR-88806000 Criciuma, SC, Brazil
· OJOPI, Elida Benquique:Univ Sao Paulo, Fac Med, Lab Neurociencias LIM 27, Hosp Clin,Inst Psiquiatria, Sao Paulo, Brazil
hcfmusp.origem.id 2-s2.0-84878403211
hcfmusp.origem.id WOS:000314043000002
hcfmusp.publisher.city WIEN
hcfmusp.publisher.country AUSTRIA
hcfmusp.relation.reference · Barichello T, 2004, NEUROCHEM RES, V29, P1749, DOI 10.1023/B:NERE.0000035811.06277.b3
· Bohbot V, 1996, P NATL ACAD SCI USA, V93, P4016, DOI 10.1073/pnas.93.9.4016
· Chaudhuri A, 1997, NEUROREPORT, V8, pR3, DOI 10.1097/00001756-199709080-00002
· Clayton DF, 2000, NEUROBIOL LEARN MEM, V74, P185, DOI 10.1006/nlme.2000.3967
· Falconer DW, 2010, PSYCHOL MED, V40, P1017, DOI 10.1017/S0033291709991243
· Fleischmann A, 2003, J NEUROSCI, V23, P9116
· Gil GA, 2004, MOL BIOL CELL, V15, P1881, DOI 10.1091/mbc.E03-09-0705
· Grimm R, 1997, BEHAV BRAIN RES, V84, P109, DOI 10.1016/S0166-4328(97)83330-X
· Guzowski JF, 2000, J NEUROSCI, V20, P3993
· Herdegen T, 1998, BRAIN RES REV, V28, P370, DOI 10.1016/S0165-0173(98)00018-6
· Hernandez PJ, 2006, LEARN MEMORY, V13, P599, DOI 10.1101/lm.335006
· HOPE BT, 1994, J NEUROSCI, V14, P4318
· Jones MW, 2001, NAT NEUROSCI, V4, P289, DOI 10.1038/85138
· Jung HY, 1996, BIOL PSYCHIAT, V40, P503, DOI 10.1016/0006-3223(95)00430-0
· Knapska E, 2004, PROG NEUROBIOL, V74, P183, DOI 10.1016/j.pneurobio.2004.05.007
· Lanahan A, 1997, J NEUROSCI, V17, P2876
· Larsen MH, 2005, BRAIN RES, V1064, P161, DOI 10.1016/j.brainres.2005.09.039
· LINK W, 1995, P NATL ACAD SCI USA, V92, P5734, DOI 10.1073/pnas.92.12.5734
· Lisanby SH, 2000, ARCH GEN PSYCHIAT, V57, P581, DOI 10.1001/archpsyc.57.6.581
· Lisanby SH, 2007, NEW ENGL J MED, V357, P1939, DOI 10.1056/NEJMct075234
· McDaniel WW, 2006, J ECT, V22, P103, DOI 10.1097/00124509-200606000-00005
· Morinobu S, 1997, SYNAPSE, V25, P313, DOI 10.1002/(SICI)1098-2396(199704)25:4<313::AID-SYN1>3.0.CO;2-D
· National Institutes of Health, 1985, EL THER NIH CONS STA, V5, P1
· NIKOLAEV E, 1992, BRAIN RES BULL, V28, P479, DOI 10.1016/0361-9230(92)90050-8
· Nobler MS, 2008, J ECT, V24, P40, DOI 10.1097/YCT.0b013e31815d6957
· O'Donovan KJ, 1998, J NEUROCHEM, V70, P1241
· Pfaffl M. W., 2004, A Z QUANTITATIVE PCR, P87
· Rapanelli M, 2009, NEUROSCIENCE, V163, P1031, DOI 10.1016/j.neuroscience.2009.07.037
· Reus GZ, 2008, N-S ARCH PHARMACOL, V376, P295, DOI 10.1007/s00210-007-0235-x
· Ribeiro S, 2004, PLOS BIOL, V2, P126, DOI 10.1371/journal.pbio.0020024
· Ronnback A, 2005, BRAIN RES, V1046, P137, DOI 10.1016/j.brainres.2005.03.051
· Rose D, 2003, BRIT MED J, V326, P1363, DOI 10.1136/bmj.326.7403.1363
· Sackeim HA, 2007, NEUROPSYCHOPHARMACOL, V32, P244, DOI 10.1038/sj.npp.1301180
· Sanchez Gonzalez R, 2009, ACTAS ESP PSIQUIATRI, V37, P343
· Smith GE, 2010, J CLIN PSYCHIAT, V71, P185, DOI 10.4088/JCP.08m04797gre
· Sng JCG, 2004, BIOL PHARM BULL, V27, P606, DOI 10.1248/bpb.27.606
· SQUIRE LR, 1986, ANN NY ACAD SCI, V462, P307, DOI 10.1111/j.1749-6632.1986.tb51265.x
· Trepel C, 1999, CEREB CORTEX, V9, P300, DOI 10.1093/cercor/9.3.300
· Tsankova NM, 2004, J NEUROSCI, V24, P5603, DOI 10.1523/JNEUROSCI.0589-04.2004
· Tzingounis AV, 2006, NEURON, V52, P403, DOI 10.1016/j.neuron.2006.10.016
· Vandesompele J, 2002, GENOME BIOL, V3, DOI 10.1186/gb-2002-3-7-research0034
· Wallace CS, 1998, J NEUROSCI, V18, P26
· Waltereit R, 2001, J NEUROSCI, V21, P5484
· Watanabe Y, 1996, J NEUROSCI, V16, P3827
· WEEKS D, 1980, BRIT J PSYCHIAT, V137, P26, DOI 10.1192/bjp.137.1.26
· Willems E, 2008, ANAL BIOCHEM, V379, P127, DOI 10.1016/j.ab.2008.04.036
· WINSTON SM, 1990, J NEUROCHEM, V54, P1920, DOI 10.1111/j.1471-4159.1990.tb04892.x
· WISDEN W, 1990, NEURON, V4, P603, DOI 10.1016/0896-6273(90)90118-Y
dc.description.index MEDLINE
hcfmusp.citation.scopus 9
hcfmusp.citation.wos 7
hcfmusp.affiliation.country Brasil


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search DSpace



Browse

My Account

Statistics