GATA3 and a dominant regulatory gene expression profile discriminate operational tolerance in human transplantation

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.author MORAES-VIEIRA, Pedro Manoel M. FMUSP-HC
TAKENAKA, Maisa C. S. FMUSP-HC
SILVA, Hernandez M. FMUSP-HC
MONTEIRO, Sandra Maria FMUSP-HC
AGENA, Fabiana FMUSP-HC
LEMOS, Francine FMUSP-HC
SAITOVITCH, David
KALIL, Jorge FMUSP-HC
COELHO, Veronica FMUSP-HC
dc.date.issued 2012
dc.identifier.citation CLINICAL IMMUNOLOGY, v.142, n.2, p.117-126, 2012
dc.identifier.issn 1521-6616
dc.identifier.uri http://observatorio.fm.usp.br/handle/OPI/423
dc.description.abstract Some organ-transplanted patients achieve a state of ""operational tolerance"" (01) in which graft function is maintained after the complete withdrawal of immunosuppressive drugs. We used a gene panel of regulatory/inflammatory molecules (FOXP3, GATA3, 100, TGFB1, TGFBR1/TBX21, TNF and IFNG) to investigate the gene expression profile in peripheral blood mononuclear cells of renal-transplanted individuals experiencing OT compared to transplanted individuals not displaying OT and healthy individuals (HI). OT subjects showed a predominant regulatory (REG) profile with higher gene expression of GATA3, FOXP3, TGFB1 and TGFB receptor 1 compared to the other groups. This predominant REG gene expression profile displayed stability over time. The significant GATA3 gene and protein expressions in OT individuals suggest that a Th2 deviation may be a relevant pathway to OT. Moreover, the capacity of the REG/INFLAMMA gene panel to discriminate OT by peripheral blood analysis indicates that this state has systemic repercussions.
dc.description.sponsorship · FAPESP
· CNPq
dc.language.iso eng
dc.publisher ACADEMIC PRESS INC ELSEVIER SCIENCE
dc.relation.ispartof Clinical Immunology
dc.rights restrictedAccess
dc.subject Operational tolerance; GATA-3; TGF-beta
dc.subject.other kidney-transplantation; peripheral-blood; immune tolerance; target genes; th2 clones; t-bet; recipients; individuals; acceptance; rejection
dc.title GATA3 and a dominant regulatory gene expression profile discriminate operational tolerance in human transplantation
dc.type article
dc.rights.holder Copyright ACADEMIC PRESS INC ELSEVIER SCIENCE
dc.description.group LIM/19
dc.identifier.doi 10.1016/j.clim.2011.08.015
dc.identifier.pmid 22019771
dc.type.category original article
dc.type.version publishedVersion
hcfmusp.author MORAES-VIEIRA, Pedro Manoel M.:FM:
hcfmusp.author TAKENAKA, Maisa C. S.:FM:
hcfmusp.author SILVA, Hernandez M.:FM:
hcfmusp.author MONTEIRO, Sandra Maria:HC:INCOR
hcfmusp.author AGENA, Fabiana:FM:
hcfmusp.author LEMOS, Francine:HC:ICHC
hcfmusp.author KALIL, Jorge:FM:MCM
hcfmusp.author COELHO, Veronica:HC:INCOR
hcfmusp.author.external · SAITOVITCH, David:Pontificia Univ Catolica Rio Grande do Sul, Sao Lucas Hosp, Div Nephrol, Porto Alegre, RS, Brazil
hcfmusp.origem.id 2-s2.0-84856536708
hcfmusp.origem.id WOS:000300388200006
hcfmusp.publisher.city SAN DIEGO
hcfmusp.publisher.country USA
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dc.description.index MEDLINE
hcfmusp.citation.scopus 25
hcfmusp.citation.wos 23
hcfmusp.affiliation.country Brasil


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