Accuracy and cost-effectiveness of different screening strategies for identifying undiagnosed COPD among primary care patients (>= 40 years) in China: a cross-sectional screening test accuracy study: findings from the Breathe Well group

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art_PAN_Accuracy_and_costeffectiveness_of_different_screening_strategies_for_2021.PDF (986.36 KB)
Citações na Scopus
10
Tipo de produção
article
Data de publicação
2021
DOI
Scopus
Web of Science
PubMed
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Editora
BMJ PUBLISHING GROUP
Autores
PAN, Zihan
DICKENS, Andrew P.
CHI, Chunhua
KONG, Xia
ENOCSON, Alexandra
COOPER, Brendan
ADAB, Peymane
CHENG, Kar Keung
SITCH, Alice J.
JOWETT, Sue
Citação
BMJ OPEN, v.11, n.9, article ID e051811, 12p, 2021
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Unidades Organizacionais
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Objectives To examine the accuracy and cost-effectiveness of various chronic obstructive pulmonary disease (COPD) screening tests and combinations within a Chinese primary care population. Design Screening test accuracy study. Setting Urban and rural community health centres in four municipalities of China: Beijing (north), Chengdu (southwest), Guangzhou (south) and Shenyang (northeast). Participants Community residents aged 40 years and above who attended community health centres for any reason were invited to participate. 2445 participants (mean age 59.8 (SD 9.6) years, 39.1% (n=956) male) completed the study (February-December 2019), 68.9% (n=1684) were never-smokers and 3.6% (n=88) had an existing COPD diagnosis. 13.7% (n=333) of participants had spirometry-confirmed airflow obstruction. Interventions Participants completed six index tests (screening questionnaires (COPD Diagnostic Questionnaire, COPD Assessment in Primary Care To Identify Undiagnosed Respiratory Disease and Exacerbation Risk (CAPTURE), Chinese Symptom-Based Questionnaire (C-S130), COPD-SQ), microspirometry (COPD-6), peak flow (model of peak flow meters used in the study (USPE)) and the reference test (ndd Easy On-PC). Primary and secondary outcomes Cases were defined as those with forced expiratory volume in one second (FEV1)/forced vital capacity (FVC) below the lower limit of normal (LLN-GLI) on the reference test. Performance of individual screening tests and their combinations was evaluated, with cost-effectiveness analyses providing cost per additional true case detected. Results Airflow measurement devices (sensitivities 64.9% (95% CI 59.5% to 70.0%) and 67.3% (95% CI 61.9% to 72.3%), specificities 89.7% (95% CI 88.4% to 91.0%) and 82.6% (95% CI 80.9% to 84.2%) for microspirometry and peak flow, respectively) generally performed better than questionnaires, the most accurate of which was C-SBQ (sensitivity 63.1% (95% CI 57.6% to 68.3%) specificity 74.2% (95% CI 72.3% to 76.1%)). The combination of C-SBQ and microspirometry used in parallel maximised sensitivity (81.4%) (95% CI 76.8% to 85.4%) and had specificity of 68.0% (95% CI 66.0% to 70.0%), with an incremental cost-effectiveness ratio of (sic)64.20 (CNY385) per additional case detected compared with peak flow. Conclusions Simple screening tests to identify undiagnosed COPD within the primary care setting in China is possible, and a combination of C-SBQ and microspirometry is the most sensitive and cost-effective. Further work is required to explore optimal cut-points and effectiveness of programme implementation.
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URI
https://observatorio.fm.usp.br/handle/OPI/42580
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Coleções
Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - LIM/05
Artigos e Materiais de Revistas Científicas - ODS/03