Neurogenic neuroprotection: Future perspectives

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP MANDEL, Mauricio FMUSP-HC
FONOFF, Erich Talamoni FMUSP-HC
TEIXEIRA, Manoel Jacobsen FMUSP-HC
CHADI, Gerson FMUSP-HC 2012
dc.identifier.citation TRANSLATIONAL NEUROSCIENCE, v.3, n.4, p.399-412, 2012
dc.identifier.issn 2081-3856
dc.description.abstract Neurogenic neuroprotection elicited by deep brain stimulation is emerging as a promising approach for treating patients with ischemic brain lesions. In rats, stimulation of the fastigial nucleus, but not dentate nucleus, has been shown to reduce the volume of focal infarction. Protection of neural tissue is a rapid intervention that has a relatively long-lasting effect, rendering fastigial nucleus stimulation (FNS) a potentially valuable method for clinical application. We review some of the main findings of animal experimental research from a clinical perspective. Results: Although the complete mechanisms of neuroprotection induced by FNS remain unclear, important data has been presented in the last two decades. The acute effect of electrical stimulation of the fastigial nucleus is likely mediated by a prolonged opening of potassium channels, and the sustained effect appears to be linked to inhibition of the apoptotic cascade. A better understanding of the cellular and molecular mechanisms underlying neurogenic neuroprotection by stimulation of deep brain nuclei, with special attention to the fastigial nucleus, can contribute toward improving neurological outcomes in ischemic brain insults.
dc.description.sponsorship · FAPESP (Sao Paulo State Foundation of Research Support)
· CNPQ (Brazilian National Counsel of Technological and Scientific Development)
dc.language.iso eng
dc.publisher VERSITA
dc.relation.ispartof Translational Neuroscience
dc.rights restrictedAccess
dc.subject Neurogenic neuroprotection; Fastigial nucleus; Stroke; Cerebrovascular accident; Subarachnoid hemorrhage
dc.subject.other spinal-cord stimulation; cerebellar fastigial nucleus; cerebral-blood-flow; rostral ventrolateral medulla; nitric-oxide synthase; acute ischemic-stroke; aneurysmal subarachnoid hemorrhage; intercellular-adhesion molecule-1; staurosporine-induced apoptosis; cortical spreading depression
dc.title Neurogenic neuroprotection: Future perspectives
dc.type article
dc.rights.holder Copyright VERSITA LIM/45 LIM/26
dc.identifier.doi 10.2478/s13380-012-0047-4
dc.type.category original article
dc.type.version publishedVersion MANDEL, Mauricio:HC:ICHC FONOFF, Erich Talamoni:HC:IPQ BOR-SENG-SHU, Edson:HC:ICHC TEIXEIRA, Manoel Jacobsen:FM:MNE CHADI, Gerson:FM:MNE 2-s2.0-84871428406 WOS:000311519900011 WARSAW POLAND
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