Please use this identifier to cite or link to this item:
https://observatorio.fm.usp.br/handle/OPI/4455| Title: | HIV-1 Proviral DNA Loads (as Determined by Quantitative PCR) in Patients Subjected to Structured Treatment Interruption after Antiretroviral Therapy Failure |
| Authors: | KOMNINAKIS, Shirley V.; SANTOS, Domingos E. M.; SANTOS, Carlos; OLIVEROS, Marcia P. R.; SANABANI, Sabri; DIAZ, Ricardo S. |
| Citation: | JOURNAL OF CLINICAL MICROBIOLOGY, v.50, n.6, p.2132-2133, 2012 |
| Abstract: | The impact of Structured Treatment Interruption (STI) in peripheral blood mononuclear cell (PBMC) proviral reservoirs in 41 highly active antiretroviral therapy (HAART)-treated viremic individuals at baseline and 12 weeks after STI was determined using quantitative PCR (qPCR). Viral load increased 0.7 log(10) and CD4 decreased 97.5 cells/mm(3) after 12 weeks. A total of 28 of the 41 individuals showed an increased proviral load, 19 with a statistically significant increase above 10%. An increase in active viral replication is an important factor in the replenishment of the proviral reservoir even for short time periods. |
| Appears in Collections: | Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - LIM/52 |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| art_SANABANI_HIV_1_Proviral_DNA_Loads_(as_Determined_by_2012.PDF Restricted Access | publishedVersion (English) | 225.07 kB | Adobe PDF | View/Open Request a copy |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.