TNF blockers show distinct patterns of immune response to the pandemic influenza A H1N1 vaccine in inflammatory arthritis patients

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP FRANCA, Ivan Leonardo Avelino FMUSP-HC
RIBEIRO, Ana Cristina Medeiros FMUSP-HC
SAAD, Carla Goncalves Schain FMUSP-HC
MORAES, Julio Cesar Bertacine FMUSP-HC
LAURINDO, Ieda Maria Magalhaes FMUSP-HC
PRECIOSO, Alexander Roberto FMUSP-HC
ISHIDA, Maria Akiko
SARTORI, Ana Marli Christovam FMUSP-HC
SILVA, Clovis Artur FMUSP-HC
BONFA, Eloisa FMUSP-HC 2012
dc.identifier.citation RHEUMATOLOGY, v.51, n.11, p.2091-2098, 2012
dc.identifier.issn 1462-0324
dc.description.abstract Methods. One hundred and twenty patients (RA, n = 41; AS, n = 57; PsA, n = 22) on anti-TNF agents (monoclonal, n = 94; soluble receptor, n = 26) were compared with 116 inflammatory arthritis patients under DMARDs and 117 healthy controls. Seroprotection, seroconversion (SC), geometric mean titre, factor increase in geometric mean titre and adverse events were evaluated 21 days after vaccination. Results. After immunization, SC rates (58.2% vs 74.3%, P = 0.017) were significantly lower in SpA patients receiving anti-TNF therapy, whereas no difference was observed in RA patients receiving this therapy compared with healthy controls (P = 0.067). SpA patients receiving mAbs (infliximab/adalimumab) had a significantly lower SC rate compared with healthy controls (51.6% vs 74.3%, P = 0.002) or those on DMARDs (51.6% vs 74.7%, P = 0.005), whereas no difference was observed for patients on etanercept (86.7% vs 74.3%, P = 0.091). Further analysis of non-seroconverting and seroconverting SpA patients revealed that the former group had a higher mean age (P = 0.003), a higher frequency of anti-TNF (P = 0.031) and mAbs (P = 0.001) and a lower frequency of MTX (P = 0.028). In multivariate logistic regression, only older age (P = 0.015) and mAb treatment (P = 0.023) remained significant factors for non-SC in SpA patients. Conclusion. This study revealed a distinct disease pattern of immune response to the pandemic influenza vaccine in inflammatory arthritis patients receiving anti-TNF agents, illustrated by a reduced immunogenicity solely in SpA patients using mAbs. Trial Registration:, ext-link-type=""uri"" xlink:href="""" xmlns:xlink="""">, NCT01151644.
dc.description.sponsorship · Fundacao de Amparo a Pesquisa do Estado de Sao Paulo [FAPESP 2009/51897-5, 2010/10749-0]
· Conselho Nacional de Desenvolvimento Cientifico e Tecnologico [CNPQ 302724/2011-7, 301411/2009-3]
· Federico Foundation
· Butantan Foundation
dc.language.iso eng
dc.publisher OXFORD UNIV PRESS
dc.relation.ispartof Rheumatology
dc.rights restrictedAccess
dc.subject vaccine; pandemic influenza A (H1N1); biologic agents; rheumatic disease; TNF blockers
dc.subject.other systemic-lupus-erythematosus; necrosis-factor antagonists; rheumatoid-arthritis; anti-tnf; disease; immunogenicity; criteria; safety; classification; adjuvant
dc.title TNF blockers show distinct patterns of immune response to the pandemic influenza A H1N1 vaccine in inflammatory arthritis patients
dc.type article
dc.rights.holder Copyright OXFORD UNIV PRESS LIM/17 LIM/36 LIM/48
dc.identifier.doi 10.1093/rheumatology/kes202
dc.identifier.pmid 22908326
dc.type.category original article
dc.type.version publishedVersion FRANCA, Ivan Leonardo Avelino:FM: RIBEIRO, Ana Cristina Medeiros:FM: AIKAWA, Nadia Emi:FM: SAAD, Carla Goncalves Schain:FM: MORAES, Julio Cesar Bertacine:FM: GOLDSTEIN-SCHAINBERG, Claudia:HC:LIM/17 LAURINDO, Ieda Maria Magalhaes:HC:ICHC PRECIOSO, Alexander Roberto:HC:ICR SARTORI, Ana Marli Christovam:HC:ICHC SILVA, Clovis Artur:HC:ICR BONFA, Eloisa:FM:MCM · ISHIDA, Maria Akiko:Univ Sao Paulo, Fac Med, Inst Adolfo Lutz, BR-05403010 Sao Paulo, Brazil 2-s2.0-84867774746 WOS:000310154300024 OXFORD ENGLAND
hcfmusp.relation.reference · Aikawa NE, 2012, J RHEUMATOL, V39, P167, DOI 10.3899/jrheum.110721
· ARNETT FC, 1988, ARTHRITIS RHEUM, V31, P315, DOI 10.1002/art.1780310302
· Borba EF, 2011, RHEUMATOLOGY, V51, P1061
· Centers for Disease Control and Prevention (CDC), 2010, PREV CONTR INFL VACC
· Crowe SR, 2011, ARTHRITIS RHEUM-US, V63, P2396, DOI 10.1002/art.30388
· Department of Health and Human Services Food and Drug Administration Center for Biologies Evaluation and Research, 2007, GUID IND CLIN DAT NE
· Elkayam O, 2010, SEMIN ARTHRITIS RHEU, V39, P442, DOI 10.1016/j.semarthrit.2008.12.002
· Elkayam O, 2011, ARTHRIT CARE RES, V63, P1062, DOI 10.1002/acr.20465
· European Committee for Medicinal Products for Human Use, 2004, EUR COMM MED PROD HU
· Fomin I, 2006, ANN RHEUM DIS, V65, P191, DOI 10.1136/ard.2005.036434
· Furst DE, 2010, SEMIN ARTHRITIS RHEU, V39, P327, DOI 10.1016/j.semarthrit.2008.10.002
· Gabay C, 2011, ARTHRITIS RHEUM-US, V63, P1486, DOI 10.1002/art.30325
· Gelinck LBS, 2008, ANN RHEUM DIS, V67, P713, DOI 10.1136/ard.2007.077552
· Haraoui B, 2011, SEMIN ARTHRITIS RHEU, V40, P371, DOI 10.1016/j.semarthrit.2010.10.004
· Kaine JL, 2007, J RHEUMATOL, V34, P272
· Kapetanovic MC, 2007, RHEUMATOLOGY, V46, P608, DOI 10.1093/rheumatology/kel366
· Kubota Tetsuo, 2007, Mod Rheumatol, V17, P531, DOI 10.1007/s10165-007-0632-5
· Lertdumrongluk P, 2012, VACCINE, V30, P1108, DOI 10.1016/j.vaccine.2011.12.023
· Lu CC, 2011, VACCINE, V29, P444, DOI 10.1016/j.vaccine.2010.10.081
· Mathian A, 2011, ARTHRITIS RHEUM-US, V63, P3502, DOI 10.1002/art.30576
· Rahier JF, 2010, RHEUMATOLOGY, V49, P1815, DOI 10.1093/rheumatology/keq183
· Rahier JF, 2011, GUT, V60, P456, DOI 10.1136/gut.2010.233981
· Ribeiro ACM, 2011, ANN RHEUM DIS, V70, P2144, DOI 10.1136/ard.2011.152983
· Saad CGS, 2011, ANN RHEUM DIS, V70, P1068, DOI 10.1136/ard.2011.150250
· Salemi S, 2010, CLIN IMMUNOL, V134, P113, DOI 10.1016/j.clim.2009.09.014
· Scallon B, 2002, J PHARMACOL EXP THER, V301, P418, DOI 10.1124/jpet.301.2.418
· Shoenfeld Y, 2011, J AUTOIMMUN, V36, P4, DOI 10.1016/j.jaut.2010.07.003
· Silva CAA, 2010, REV BRAS REUMATOL, V50, P351
· Strangfeld A, 2009, JAMA-J AM MED ASSOC, V301, P737, DOI 10.1001/jama.2009.146
· Taylor W, 2006, ARTHRITIS RHEUM, V54, P2665, DOI 10.1002/art.21972
· Urowitz MB, 2011, ARTHRIT CARE RES, V63, P1517, DOI 10.1002/acr.20599
· van Assen S, 2011, ANN RHEUM DIS, V70, P414, DOI 10.1136/ard.2010.137216
· Walls RS, 2008, LANCET INFECT DIS, V8, P601, DOI 10.1016/S1473-3099(08)70227-5
· Young F, 2001, VACCINE, V29, P8788
dc.description.index MEDLINE
hcfmusp.citation.scopus 37
hcfmusp.citation.wos 33 Brasil

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