Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/5020
Title: MMP-8 polymorphism is genetic marker to tendinopathy primary posterior tibial tendon
Authors: Godoy-Santos, A.Ortiz, R. T.Mattar Junior, R.Fernandes, T. D.Santos, M. C. L. G.
Citation: SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS, v.24, n.1, p.220-223, 2014
Abstract: Posterior tibial tendon is particularly vulnerable and is responsible for much morbidity in sportspersons. Some patients have a predisposition without a clinically recognized cause, suggesting that individual characteristics, inclusive genetic inheritance, play an important role in tendinopathy. Matrix metalloproteinase (MMP)-8 is a proteinase capable of degrading a large amount of extracellular proteins, and influence degradation and remodeling of collagen. To determine whether the -799 polymorphism in the promoter of MMP-8 gene is associated with tendinopathy in posterior tibial tendon, 50 patients undergoing surgical procedures and anatomopathological diagnosis of degenerative lesions of the posterior tibial tendon and 100 control patients with posterior tibial tendon integrity and without signs of degeneration in magnetic resonance imaging were evaluated for the -799 MMP-8 polymorphism. There was a significant difference in the presence of the different alleles (P=0.001) and genotype (P=0.003) between the control group and the test group for the MMP-8 gene. The polymorphism at position -799 of the gene for MMP-8 is associated with tendinopathy primary posterior tibial tendon in the population studied. The results suggest that individuals with the T allele are at greater risk of developing tendinopathy.
Appears in Collections:

Artigos e Materiais de Revistas Científicas - FM/MOT
Departamento de Ortopedia e Traumatologia - FM/MOT

Artigos e Materiais de Revistas Científicas - HC/IOT
Instituto de Ortopedia e Traumatologia - HC/IOT

Artigos e Materiais de Revistas Científicas - LIM/41
LIM/41 - Laboratório de Investigação Médica do Sistema Músculoesquelético


Files in This Item:
File Description SizeFormat 
art_Godoy-Santos_MMP_8_polymorphism_is_genetic_marker_to_tendinopathy_2014.PDF
  Restricted Access
publishedVersion (English)94.41 kBAdobe PDFView/Open Request a copy

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.