https://observatorio.fm.usp.br/handle/OPI/5063
DC Field | Value | Language |
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dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | - |
dc.contributor.author | FARFEL, Jose Marcelo | - |
dc.contributor.author | NITRINI, Ricardo | - |
dc.contributor.author | SUEMOTO, Claudia Kimie | - |
dc.contributor.author | GRINBERG, Lea Tenenholz | - |
dc.contributor.author | FERRETTI, Renata Eloah Lucena | - |
dc.contributor.author | LEITE, Renata Elaine Paraizo | - |
dc.contributor.author | TAMPELLINI, Edilaine | - |
dc.contributor.author | LIMA, Luzia | - |
dc.contributor.author | FARIAS, Daniela Souza | - |
dc.contributor.author | NEVES, Ricardo Caires | - |
dc.contributor.author | RODRIGUEZ, Roberta Diehl | - |
dc.contributor.author | MENEZES, Paulo Rossi | - |
dc.contributor.author | FREGNI, Felipe | - |
dc.contributor.author | BENNETT, David A. | - |
dc.contributor.author | PASQUALUCCI, Carlos Augusto | - |
dc.contributor.author | JACOB FILHO, Wilson | - |
dc.date.accessioned | 2014-04-25T21:50:15Z | - |
dc.date.available | 2014-04-25T21:50:15Z | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | NEUROLOGY, v.81, n.7, p.650-657, 2013 | - |
dc.identifier.issn | 0028-3878 | - |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/5063 | - |
dc.description.abstract | Objective: We conducted a clinicopathologic study in a large population with very low levels of education to determine whether very few years of education could contribute to cognitive reserve and modify the relation of neuropathologic indices to dementia. Methods: In this cross-sectional study, we included 675 individuals 50 years of age or older from the Brazilian Aging Brain Study Group. Cognitive abilities were evaluated through a structured interview with an informant at the time of autopsy, including the Clinical Dementia Rating (CDR) scale. Neuropathologic examinations were performed using immunohistochemistry and following internationally accepted criteria. Multivariate linear regression models were conducted to determine whether the association between cognitive abilities (measured by CDR sum of boxes) and years of education was independent of sociodemographic variables and neuropathologic indices, including neuritic plaques, neurofibrillary tangles, lacunar infarctions, small-vessel disease, and Lewy bodies. In addition, interaction models were used to examine whether education modified the relation between neuropathologic indices and cognition. Results: Mean education was 3.9 +/- 3.5 years. Formal education was associated with a lower CDR sum of boxes (beta = -0.197; 95% confidence interval -0.343, -0.052; p = 0.008), after adjustment for sociodemographic variables and neuropathologic indices. Furthermore, education modified the relationship of lacunar infarcts with cognitive abilities (p = 0.04). Conclusions: Even a few years of formal education contributes to cognitive reserve. | - |
dc.description.sponsorship | Fundacao de Apoio a Pesquisa do Estado de Sao Paulo-FAPESP [2009/01934-4] | - |
dc.description.sponsorship | University of Sao Paulo, Medical School, Department of Pathology [FMUSP-HC/LIM-22] | - |
dc.description.sponsorship | Coordenadoria de Apoio ao Pessoal de Nivel Superior-CAPES, Brazil | - |
dc.description.sponsorship | John Douglas French Alzheimer Foundation | - |
dc.description.sponsorship | Hospital Israelita Albert Einstein and Research Institute | - |
dc.description.sponsorship | National Institutes of Health (NIH) [1R01AG040311-01, 2P50AG023501, P30AG10161, R01AG17917] | - |
dc.description.sponsorship | Albert Einstein Education and Research Institute, Sao Paulo [240/07] | - |
dc.language.iso | eng | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.relation.ispartof | Neurology | - |
dc.rights | openAccess | - |
dc.subject.other | alzheimers-disease | - |
dc.subject.other | older persons | - |
dc.subject.other | dementia | - |
dc.subject.other | neuropathology | - |
dc.subject.other | population | - |
dc.subject.other | brain | - |
dc.subject.other | prevalence | - |
dc.subject.other | pathology | - |
dc.subject.other | plaques | - |
dc.title | Very low levels of education and cognitive reserve A clinicopathologic study | - |
dc.type | article | - |
dc.rights.holder | Copyright LIPPINCOTT WILLIAMS & WILKINS | - |
dc.contributor.groupauthor | Brazilian Aging Brain Study Grp | - |
dc.identifier.doi | 10.1212/WNL.0b013e3182a08f1b | - |
dc.identifier.pmid | 23873971 | - |
dc.subject.wos | Clinical Neurology | - |
dc.type.category | original article | - |
dc.type.version | publishedVersion | - |
hcfmusp.author.external | FERRETTI, Renata Eloah Lucena:Univ Sao Paulo, Sch Nursing, Med Surg Nursing Dept, Sao Paulo, Brazil | - |
hcfmusp.author.external | LIMA, Luzia:Univ Sao Paulo, Sch Med, Brazilian Aging Brain Study Grp, Sao Paulo, Brazil; Hosp Israelita Brasileiro Albert Einstein, Inst Israelita Ensino & Pesquisa, Sao Paulo, Brazil | - |
hcfmusp.author.external | NEVES, Ricardo Caires:Univ Sao Paulo, Sch Med, Brazilian Aging Brain Study Grp, Sao Paulo, Brazil | - |
hcfmusp.author.external | FREGNI, Felipe:Harvard Univ, Sch Med, Dept Phys Med & Rehabil, Boston, MA USA; Harvard Univ, Sch Med, Dept Neurol, Boston, MA 02115 USA | - |
hcfmusp.author.external | BENNETT, David A.:Rush Univ, Med Ctr, Rush Alzheimers Dis Ctr, Chicago, IL 60612 USA | - |
hcfmusp.description.beginpage | 650 | - |
hcfmusp.description.endpage | 657 | - |
hcfmusp.description.issue | 7 | - |
hcfmusp.description.volume | 81 | - |
hcfmusp.origem | WOS | - |
hcfmusp.origem.id | 2-s2.0-84884486904 | - |
hcfmusp.origem.id | WOS:000330743500013 | - |
hcfmusp.publisher.city | PHILADELPHIA | - |
hcfmusp.publisher.country | USA | - |
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dc.description.index | MEDLINE | - |
dc.identifier.eissn | 1526-632X | - |
hcfmusp.remissive.sponsorship | Albert Einstein | - |
hcfmusp.remissive.sponsorship | CAPES | - |
hcfmusp.remissive.sponsorship | FAPESP | - |
hcfmusp.remissive.sponsorship | FMUSP-HC | - |
hcfmusp.remissive.sponsorship | NIH | - |
hcfmusp.citation.scopus | 123 | - |
hcfmusp.scopus.lastupdate | 2024-03-29 | - |
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art_FARFEL_Very_low_levels_of_education_and_cognitive_reserve_2013.PDF | publishedVersion (English) | 328.24 kB | Adobe PDF | View/Open |
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