Very low levels of education and cognitive reserve A clinicopathologic study

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.author FARFEL, Jose Marcelo FMUSP-HC
NITRINI, Ricardo FMUSP-HC
SUEMOTO, Claudia Kimie FMUSP-HC
GRINBERG, Lea Tenenholz FMUSP-HC
FERRETTI, Renata Eloah Lucena
LEITE, Renata Elaine Paraizo FMUSP-HC
TAMPELLINI, Edilaine FMUSP-HC
LIMA, Luzia
FARIAS, Daniela Souza FMUSP-HC
NEVES, Ricardo Caires
RODRIGUEZ, Roberta Diehl FMUSP-HC
MENEZES, Paulo Rossi FMUSP-HC
FREGNI, Felipe
BENNETT, David A.
PASQUALUCCI, Carlos Augusto FMUSP-HC
JACOB FILHO, Wilson FMUSP-HC
dc.date.issued 2013
dc.identifier.citation NEUROLOGY, v.81, n.7, p.650-657, 2013
dc.identifier.issn 0028-3878
dc.identifier.uri http://observatorio.fm.usp.br/handle/OPI/5063
dc.description.abstract Objective: We conducted a clinicopathologic study in a large population with very low levels of education to determine whether very few years of education could contribute to cognitive reserve and modify the relation of neuropathologic indices to dementia. Methods: In this cross-sectional study, we included 675 individuals 50 years of age or older from the Brazilian Aging Brain Study Group. Cognitive abilities were evaluated through a structured interview with an informant at the time of autopsy, including the Clinical Dementia Rating (CDR) scale. Neuropathologic examinations were performed using immunohistochemistry and following internationally accepted criteria. Multivariate linear regression models were conducted to determine whether the association between cognitive abilities (measured by CDR sum of boxes) and years of education was independent of sociodemographic variables and neuropathologic indices, including neuritic plaques, neurofibrillary tangles, lacunar infarctions, small-vessel disease, and Lewy bodies. In addition, interaction models were used to examine whether education modified the relation between neuropathologic indices and cognition. Results: Mean education was 3.9 +/- 3.5 years. Formal education was associated with a lower CDR sum of boxes (beta = -0.197; 95% confidence interval -0.343, -0.052; p = 0.008), after adjustment for sociodemographic variables and neuropathologic indices. Furthermore, education modified the relationship of lacunar infarcts with cognitive abilities (p = 0.04). Conclusions: Even a few years of formal education contributes to cognitive reserve.
dc.description.sponsorship · Fundacao de Apoio a Pesquisa do Estado de Sao Paulo-FAPESP [2009/01934-4]
· University of Sao Paulo, Medical School, Department of Pathology [FMUSP-HC/LIM-22]
· Coordenadoria de Apoio ao Pessoal de Nivel Superior-CAPES, Brazil
· John Douglas French Alzheimer Foundation
· Hospital Israelita Albert Einstein and Research Institute
· National Institutes of Health (NIH) [1R01AG040311-01, 2P50AG023501, P30AG10161, R01AG17917]
· Albert Einstein Education and Research Institute, Sao Paulo [240/07]
dc.language.iso eng
dc.publisher LIPPINCOTT WILLIAMS & WILKINS
dc.relation.ispartof Neurology
dc.rights openAccess
dc.subject.other alzheimers-disease; older persons; dementia; neuropathology; population; brain; prevalence; pathology; plaques
dc.title Very low levels of education and cognitive reserve A clinicopathologic study
dc.type article
dc.rights.holder Copyright LIPPINCOTT WILLIAMS & WILKINS
dc.contributor.groupauthor Brazilian Aging Brain Study Grp
dc.description.group LIM/22
dc.description.group LIM/15
dc.description.group LIM/39
dc.identifier.doi 10.1212/WNL.0b013e3182a08f1b
dc.identifier.pmid 23873971
dc.type.category original article
dc.type.version publishedVersion
hcfmusp.author FARFEL, Jose Marcelo:FM:MCM
hcfmusp.author NITRINI, Ricardo:FM:MNE
hcfmusp.author SUEMOTO, Claudia Kimie:FM:MCM
hcfmusp.author GRINBERG, Lea Tenenholz:FM:MPT
hcfmusp.author LEITE, Renata Elaine Paraizo:HC:LIM/22
hcfmusp.author TAMPELLINI, Edilaine:FM:
hcfmusp.author FARIAS, Daniela Souza:HC:LIM/22
hcfmusp.author RODRIGUEZ, Roberta Diehl:FM:
hcfmusp.author MENEZES, Paulo Rossi:FM:MPR
hcfmusp.author PASQUALUCCI, Carlos Augusto:FM:MPT
hcfmusp.author JACOB FILHO, Wilson:FM:MCM
hcfmusp.author.external · FERRETTI, Renata Eloah Lucena:Univ Sao Paulo, Sch Nursing, Med Surg Nursing Dept, Sao Paulo, Brazil
· LIMA, Luzia:Univ Sao Paulo, Sch Med, Brazilian Aging Brain Study Grp, Sao Paulo, Brazil; Hosp Israelita Brasileiro Albert Einstein, Inst Israelita Ensino & Pesquisa, Sao Paulo, Brazil
· NEVES, Ricardo Caires:Univ Sao Paulo, Sch Med, Brazilian Aging Brain Study Grp, Sao Paulo, Brazil
· FREGNI, Felipe:Harvard Univ, Sch Med, Dept Phys Med & Rehabil, Boston, MA USA; Harvard Univ, Sch Med, Dept Neurol, Boston, MA 02115 USA
· BENNETT, David A.:Rush Univ, Med Ctr, Rush Alzheimers Dis Ctr, Chicago, IL 60612 USA
hcfmusp.origem.id 2-s2.0-84884486904
hcfmusp.origem.id WOS:000330743500013
hcfmusp.publisher.city PHILADELPHIA
hcfmusp.publisher.country USA
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dc.description.index MEDLINE
dc.identifier.eissn 1526-632X
hcfmusp.citation.scopus 60
hcfmusp.citation.wos 55
hcfmusp.affiliation.country Brasil
hcfmusp.affiliation.country Estados Unidos


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