Maternal distress, DNA methylation, and fetal programing of stress physiology in Brazilian mother-infant pairs

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art_WILEY_Maternal_distress_DNA_methylation_and_fetal_programing_of_2023.PDF (580.95 KB)
Citações na Scopus
3
Tipo de produção
article
Data de publicação
2023
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
WILEY
Autores
WILEY, Kyle S.
PANTER-BRICK, Catherine
FRACOLLI, Lislaine Aparecida
CHIESA, Anna Maria
Citação
DEVELOPMENTAL PSYCHOBIOLOGY, v.65, n.1, article ID e22352, 16p, 2023
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Maternal prenatal psychosocial stress is associated with adverse hypothalamic-pituitary-adrenal axis (HPAA) function among infants. Although the biological mechanisms influencing this process remain unknown, altered DNA methylation is considered to be one potential mechanism. We investigated associations between maternal prenatal psychological distress, infant salivary DNA methylation, and stress physiology at 12 months. Mother's distress was measured via depression and anxiety in early and late pregnancy in a cohort of 80 pregnant adolescents. Maternal hair cortisol was collected during pregnancy. Saliva samples were collected from infants at 12 months to quantify DNA methylation of three stress-related genes (FKBP5, NR3C1, OXTR) (n = 62) and diurnal cortisol (n = 29). Multivariable linear regression was used to test for associations between prenatal psychological distress, and infant DNA methylation and cortisol. Hair cortisol concentrations in late pregnancy were negatively associated with two sites of FKBP5 (site 1: B = -22.33, p = .003; site 2: B = -15.60, p = .012). Infants of mothers with elevated anxiety symptoms in late pregnancy had lower levels of OXTR2 CpG2 methylation (B = -2.17, p = .03) and higher evening salivary cortisol (B = 0.41, p = .03). Furthermore, OXTR2 methylation was inversely associated with evening cortisol (B = -0.14, p-value <= .001). Our results are, to our knowledge, the first evidence that the methylation of the oxytocin receptor may contribute to the regulation of HPAA during infancy.
Palavras-chave
anxiety, cortisol, depression, DNA methylation, glucocorticoid receptor, oxytocin receptor, pregnancy
URI
https://observatorio.fm.usp.br/handle/OPI/51578
Referências
  1. Armstrong DA, 2014, FASEB J, V28, P2088, DOI 10.1096/fj.13-238402
  2. Barha CK, 2019, J DEV ORIG HLTH DIS, V10, P73, DOI 10.1017/S2040174418000880
  3. Beck A. T., 1996, SAN ANTONIO, V78, P490
  4. BECK AT, 1961, ARCH GEN PSYCHIAT, V4, P561, DOI 10.1001/archpsyc.1961.01710120031004
  5. Beck AT, 1993, BECK ANXIETY INVENTO
  6. Beydoun H, 2008, PAEDIATR PERINAT EP, V22, P438, DOI 10.1111/j.1365-3016.2008.00951.x
  7. Binder EB, 2009, PSYCHONEUROENDOCRINO, V34, P99, DOI [10.1016/j.psyneuen.2008.08.018, 10.1016/j.psyneuen.2009.05.021]
  8. Bleker LS, 2017, PSYCHONEUROENDOCRINO, V83, P172, DOI 10.1016/j.psyneuen.2017.05.026
  9. Braig S, 2016, PAEDIATR PERINAT EP, V30, P97, DOI 10.1111/ppe.12255
  10. Braithwaite EC, 2015, EPIGENETICS-US, V10, P408, DOI 10.1080/15592294.2015.1039221
  11. Bush NR, 2017, DEV PSYCHOPATHOL, V29, P1553, DOI 10.1017/S0954579417001237
  12. Thompson LP, 2012, J PREGNANCY, V2012, DOI 10.1155/2012/582748
  13. Thompson TM, 2013, BEHAV GENET, V43, P168, DOI 10.1007/s10519-012-9579-1
  14. Toepfer P, 2017, NEUROSCI BIOBEHAV R, V73, P293, DOI 10.1016/j.neubiorev.2016.12.026
  15. Turecki G, 2016, BIOL PSYCHIAT, V79, P87, DOI 10.1016/j.biopsych.2014.11.022
  16. Unternaehrer E, 2016, SOC COGN AFFECT NEUR, V11, P1460, DOI 10.1093/scan/nsw051
  17. van den Bergh BRH, 2008, NEUROPSYCHOPHARMACOL, V33, P536, DOI 10.1038/sj.npp.1301450
  18. Vidal AC, 2013, INT J OBESITY, V37, P907, DOI 10.1038/ijo.2013.47
  19. Wadhwa PD, 2009, SEMIN REPROD MED, V27, P358, DOI 10.1055/s-0029-1237424
  20. Wang P, 2015, J NEUROIMMUNOL, V289, P152, DOI 10.1016/j.jneuroim.2015.11.001
  21. Weaver ICG, 2004, NAT NEUROSCI, V7, P847, DOI 10.1038/nn1276
  22. Zannas AS, 2017, MOL PSYCHIATR, V22, P640, DOI 10.1038/mp.2017.35
  23. Zijlmans MAC, 2015, NEUROSCI BIOBEHAV R, V53, P1, DOI 10.1016/j.neubiorev.2015.02.015
  24. Cappi C, 2016, BMC NEUROSCI, V17, DOI 10.1186/s12868-016-0313-4
  25. Cardoso C, 2014, PSYCHONEUROENDOCRINO, V49, P161, DOI 10.1016/j.psyneuen.2014.07.014
  26. Casanueva E, 2006, J NUTR, V136, P2498, DOI 10.1093/jn/136.10.2498
  27. Cecil CAM, 2014, MOL PSYCHIATR, V19, P1071, DOI 10.1038/mp.2014.95
  28. Conradt E, 2019, INFANT MENT HEALTH J, V40, P513, DOI 10.1002/imhj.21789
  29. Conradt E, 2018, DEV PSYCHOPATHOL, V30, P807, DOI 10.1017/S0954579418000469
  30. Conradt E, 2016, CHILD DEV, V87, P73, DOI 10.1111/cdev.12483
  31. Conradt E, 2015, FRONT BEHAV NEUROSCI, V9, DOI 10.3389/fnbeh.2015.00130
  32. Conradt E, 2013, EPIGENETICS-US, V8, P1321, DOI 10.4161/epi.26634
  33. Danoff Joshua S, 2021, Compr Psychoneuroendocrinol, V8, P100098, DOI 10.1016/j.cpnec.2021.100098
  34. Davis EP, 2010, CHILD DEV, V81, P131, DOI 10.1111/j.1467-8624.2009.01385.x
  35. Davis EP, 2007, J AM ACAD CHILD PSY, V46, P737, DOI 10.1097/chi.0b013e318047b775
  36. Davis EP, 2011, J CHILD PSYCHOL PSYC, V52, P119, DOI 10.1111/j.1469-7610.2010.02314.x
  37. Entringer S, 2015, PSYCHONEUROENDOCRINO, V62, P366, DOI 10.1016/j.psyneuen.2015.08.019
  38. Euclydes VLV, 2022, J DEV ORIG HLTH DIS, V13, P556, DOI 10.1017/S2040174421000738
  39. Fatori D, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-93938-7
  40. Ferri CP, 2007, BMC PUBLIC HEALTH, V7, DOI 10.1186/1471-2458-7-209
  41. Fries ABW, 2005, P NATL ACAD SCI USA, V102, P17237, DOI 10.1073/pnas.0504767102
  42. Galbally M, 2018, PSYCHONEUROENDOCRINO, V90, P1, DOI 10.1016/j.psyneuen.2018.01.004
  43. Gomes-Oliveira MH, 2012, REV BRAS PSIQUIATR, V34, P389, DOI 10.1016/j.rbp.2012.03.005
  44. Graignic-Philippe R, 2014, NEUROSCI BIOBEHAV R, V43, P137, DOI 10.1016/j.neubiorev.2014.03.022
  45. Grimm S, 2014, SOC COGN AFFECT NEUR, V9, P1828, DOI 10.1093/scan/nsu020
  46. Grote NK, 2010, ARCH GEN PSYCHIAT, V67, P1012, DOI 10.1001/archgenpsychiatry.2010.111
  47. Gutteling BM, 2005, EUR CHILD ADOLES PSY, V14, P41, DOI 10.1007/s00787-005-0435-1
  48. Heim C, 2009, MOL PSYCHIATR, V14, P954, DOI 10.1038/mp.2008.112
  49. Heinrichs M, 2003, BIOL PSYCHIAT, V54, P1389, DOI 10.1016/S0006-3223(03)00465-7
  50. Hompes T, 2013, J PSYCHIATR RES, V47, P880, DOI 10.1016/j.jpsychires.2013.03.009
  51. Irwin JL, 2021, PSYCHONEUROENDOCRINO, V125, DOI 10.1016/j.psyneuen.2020.105106
  52. JACOBI PR, 1994, ENVIRON URBAN, V6, P87, DOI 10.1177/095624789400600206
  53. Kertes DA, 2016, CHILD DEV, V87, P61, DOI 10.1111/cdev.12487
  54. King L.S., 2022, COMPREHENSIVE PSYCHO, V9
  55. King L, 2017, HORM BEHAV, V96, P84, DOI 10.1016/j.yhbeh.2017.09.006
  56. Kraaijenvanger EJ, 2019, NEUROSCI BIOBEHAV R, V96, P127, DOI 10.1016/j.neubiorev.2018.11.016
  57. Lee HJ, 2009, PROG NEUROBIOL, V88, P127, DOI 10.1016/j.pneurobio.2009.04.001
  58. Lester BM, 2018, PEDIATRICS, V142, DOI 10.1542/peds.2017-1890
  59. Leuine A, 2007, PEPTIDES, V28, P1162, DOI 10.1016/j.peptides.2007.04.016
  60. Liu CH, 2020, PSYCHONEUROENDOCRINO, V117, DOI 10.1016/j.psyneuen.2020.104675
  61. Liu CH, 2017, DEV PSYCHOBIOL, V59, P916, DOI 10.1002/dev.21557
  62. Lobmaier SM, 2020, ARCH GYNECOL OBSTET, V301, P405, DOI 10.1007/s00404-019-05390-8
  63. Martin CL, 2019, EPIGENETICS-US, V14, P325, DOI 10.1080/15592294.2019.1581594
  64. McQuaid RJ, 2014, NEUROSCI BIOBEHAV R, V45, P305, DOI 10.1016/j.neubiorev.2014.07.005
  65. Meinlschmidt G, 2007, BIOL PSYCHIAT, V61, P1109, DOI 10.1016/j.biopsych.2006.09.007
  66. Mill J, 2013, NAT REV GENET, V14, P585, DOI 10.1038/nrg3405
  67. Minakova E, 2018, BIRTH DEFECTS RES, V110, P1539, DOI 10.1002/bdr2.1416
  68. Monk C, 2003, J DEV BEHAV PEDIATR, V24, P32, DOI 10.1097/00004703-200302000-00008
  69. Monk C, 2016, AM J PSYCHIAT, V173, P705, DOI 10.1176/appi.ajp.2015.15091171
  70. Moskalev EA, 2011, NUCLEIC ACIDS RES, V39, DOI 10.1093/nar/gkr213
  71. Mulligan CJ, 2012, EPIGENETICS-US, V7, P853, DOI 10.4161/epi.21180
  72. Mustonen P, 2019, PSYCHONEUROENDOCRINO, V109, DOI 10.1016/j.psyneuen.2019.104383
  73. Neumann ID, 2002, PROG BRAIN RES, V139, P147
  74. Neumann ID, 2016, BIOL PSYCHIAT, V79, P213, DOI 10.1016/j.biopsych.2015.06.004
  75. O'Connor TG, 2002, BRIT J PSYCHIAT, V180, P502, DOI 10.1192/bjp.180.6.502
  76. O'Connor TG, 2014, BIOL PSYCHOL, V96, P35, DOI 10.1016/j.biopsycho.2013.11.002
  77. Oberlander TF, 2008, EPIGENETICS-US, V3, P97, DOI 10.4161/epi.3.2.6034
  78. Opacka-Juffry J, 2012, STRESS, V15, P1, DOI 10.3109/10253890.2011.560309
  79. Orta OR, 2019, STRESS, V22, P60, DOI 10.1080/10253890.2018.1504917
  80. Ostlund BD, 2016, FRONT BEHAV NEUROSCI, V10, DOI 10.3389/fnbeh.2016.00147
  81. Palma-Gudiel H, 2015, EPIGENETICS-US, V10, P893, DOI 10.1080/15592294.2015.1088630
  82. Palma-Gudiel H, 2015, NEUROSCI BIOBEHAV R, V55, P520, DOI 10.1016/j.neubiorev.2015.05.016
  83. Paquette AG, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0104913
  84. Pearson RM, 2013, JAMA PSYCHIAT, V70, P1312, DOI 10.1001/jamapsychiatry.2013.2163
  85. Perroud N, 2014, WORLD J BIOL PSYCHIA, V15, P334, DOI 10.3109/15622975.2013.866693
  86. Pierrehumbert B, 2010, NEUROSCIENCE, V166, P168, DOI 10.1016/j.neuroscience.2009.12.016
  87. Pluess M, 2010, BIOL PSYCHOL, V83, P169, DOI 10.1016/j.biopsycho.2009.12.005
  88. PRICE DA, 1983, ARCH DIS CHILD, V58, P454, DOI 10.1136/adc.58.6.454
  89. Quintao S, 2013, PSICOL-REFLEX CRIT, V26, P305, DOI 10.1590/S0102-79722013000200010
  90. Radtke KM, 2011, TRANSL PSYCHIAT, V1, DOI 10.1038/tp.2011.21
  91. Rah JH, 2008, J NUTR, V138, P1505, DOI 10.1093/jn/138.8.1505
  92. Ribeiro WS, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0063545
  93. Rijlaarsdam J, 2017, AUTISM RES, V10, P430, DOI 10.1002/aur.1681
  94. Rippe RCA, 2016, PSYCHONEUROENDOCRINO, V66, P56, DOI 10.1016/j.psyneuen.2015.12.016
  95. Rodney NC, 2014, AM J PHYS ANTHROPOL, V155, P200, DOI 10.1002/ajpa.22568
  96. Rowlands A, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph182212152
  97. Russell E, 2012, PSYCHONEUROENDOCRINO, V37, P589, DOI 10.1016/j.psyneuen.2011.09.009
  98. Santiago LB, 1996, CLIN ENDOCRINOL, V44, P157, DOI 10.1046/j.1365-2265.1996.645466.x
  99. Scharlau F, 2018, STRESS, V21, P43, DOI 10.1080/10253890.2017.1392507
  100. Schetter CD, 2011, ANNU REV PSYCHOL, V62, P531, DOI 10.1146/annurev.psych.031809.130727
  101. SCHOLL TO, 1990, AM J CLIN NUTR, V51, P790, DOI 10.1093/ajcn/51.5.790
  102. Seckl JR, 2004, ANN NY ACAD SCI, V1032, P63, DOI 10.1196/annals.1314.006
  103. Smith AK, 2015, AM J MED GENET B, V168, P36, DOI 10.1002/ajmg.b.32278
  104. Sosnowski DW, 2018, DEV PSYCHOBIOL, V60, P127, DOI 10.1002/dev.21604
  105. Stalder T, 2012, BRAIN BEHAV IMMUN, V26, P1019, DOI 10.1016/j.bbi.2012.02.002
  106. Straub H, 2012, AM J OBSTET GYNECOL, V207, DOI 10.1016/j.ajog.2012.06.033

Coleções
Artigos e Materiais de Revistas Científicas - FM/MPR
Artigos e Materiais de Revistas Científicas - FM/MPE
Artigos e Materiais de Revistas Científicas - FM/MPS
Artigos e Materiais de Revistas Científicas - HC/IPq
Artigos e Materiais de Revistas Científicas - LIM/23
Artigos e Materiais de Revistas Científicas - LIM/39