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Title: | Acute cholestatic hepatitis caused by amoxicillin/clavulanate |
Authors: | BERALDO, Daniel Oliveira; MELO, Joanderson Fernandes; BONFIM, Alexandre Vidal; TEIXEIRA, Andrei Alkmim; TEIXEIRA, Ricardo Alkmim; DUARTE, Andre Loyola |
Citation: | WORLD JOURNAL OF GASTROENTEROLOGY, v.19, n.46, p.8789-8792, 2013 |
Abstract: | Amoxicillin/clavulanate is a synthetic penicillin that is currently commonly used, especially for the treatment of respiratory and cutaneous infections. In general, it is a well-tolerated oral antibiotic. However, amoxicillin/clavulanate can cause adverse effects, mainly cutaneous, gastrointestinal, hepatic and hematologic, in some cases. Presented here is a case report of a 63-year-old male patient who developed cholestatic hepatitis after recent use of amoxicillin/clavulanate. After 6 wk of prolonged use of the drug, he began to show signs of cholestatic icterus and developed severe hyperbilirubinemia (total bilirubin > 300 mg/L). Diagnostic investigation was conducted by ultrasonography of the upper abdomen, serum tests for infection history, laboratory screening of autoimmune diseases, nuclear magnetic resonance (NMR) of the abdomen with bile duct-NMR and transcutaneous liver biopsy guided by ultrasound. The duration of disease was approximately 4 mo, with complete resolution of symptoms and laboratory changes at the end of that time period. Specific treatment was not instituted, only a combination of anti-emetic (metoclopramide) and cholestyramine for pruritus. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - HC/InCor Artigos e Materiais de Revistas Científicas - ODS/03 |
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art_TEIXEIRA_Acute_cholestatic_hepatitis_caused_by_amoxicillin_clavulanate_2013.PDF | publishedVersion (English) | 1.12 MB | Adobe PDF | View/Open |
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