Leukocyte Depletion During CPB: Effects on Inflammation and Lung Function

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art_AMORIM_Leukocyte_Depletion_During_CPB_Effects_on_Inflammation_and_2014.PDF (231.39 KB)
Citações na Scopus
14
Tipo de produção
article
Data de publicação
2014
Editora
SPRINGER/PLENUM PUBLISHERS
DOI
Indexadores
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Autores
SILVA JR., Francisco Costa da
Autor de Grupo de pesquisa
Editores
Coordenadores
Organizadores
Citação
INFLAMMATION, v.37, n.1, p.196-204, 2014
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Cardiopulmonary bypass (CPB) is related to inflammatory response and pulmonary dysfunction. The aim of this study was to evaluate the effects of CPB leukocyte filtration on inflammation and lung function after coronary artery bypass grafting (CABG). A prospective randomized study was performed to compare CABG patients undergoing CPB leukocyte filtration (n = 9) or standard CPB (n = 11). Computed tomography, oxygenation, leukocyte count, hemodynamic data, PaO2/FiO(2), shunt fraction, interleukins, elastase, and myeloperoxidase were evaluated. Data were analyzed using two-factor ANOVA for repeated measurements. The filtered group showed lower neutrophil counts up to 50 min of CPB, lower shunt fraction up to 6 h after surgery, and lower levels of IL-10 at the end of surgery (p < 0.05). There was no statistically significant difference between groups related to other parameters. Leukodepletion during CPB results in neutrophil sequestration by a short time, decreased IL-10 serum levels, and lower worsening of lung function only temporarily.
Palavras-chave
coronary artery bypass surgery, leukocyte reduction filtrations, pulmonary function, systemic inflammatory response
URI
https://observatorio.fm.usp.br/handle/OPI/5324
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MCG
Artigos e Materiais de Revistas Científicas - HC/ICESP
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - LIM/08
Artigos e Materiais de Revistas Científicas - ODS/03