Oral Infections and Orofacial Pain in Alzheimer's Disease: A Case-Control Study

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.author ROLIM, Thais de Souza
FABRI, Gisele Maria Campos
TEIXEIRA, Manoel Jacobsen FMUSP-HC
CESTARI, Jose Augusto Ferrari FMUSP-HC
SIQUEIRA, Silvia Regina Dowgan T. de
dc.date.issued 2014
dc.identifier.citation JOURNAL OF ALZHEIMERS DISEASE, v.38, n.4, p.823-829, 2014
dc.identifier.issn 1387-2877
dc.identifier.uri http://observatorio.fm.usp.br/handle/OPI/5396
dc.description.abstract Background: Dental infections are frequent and have recently been implicated as a possible risk factor for Alzheimer's disease (AD). Despite a lack of studies investigating orofacial pain in this patient group, dental conditions are known to be a potential cause of pain and to affect quality of life and disease progression. Objectives: To evaluate oral status, mandibular function and orofacial pain in patients with mild AD versus healthy subjects matched for age and gender. Methods: Twenty-nine patients and 30 control subjects were evaluated. The protocol comprised a clinical questionnaire and dental exam, research diagnostic criteria for temporomandibular disorders, the McGill Pain Questionnaire, the decayed, missing, and filled teeth index, and included a full periodontal evaluation. AD signs and symptoms as well as associated factors were evaluated by a trained neurologist. Results: A higher prevalence of orofacial pain (20.7%, p < 0.001), articular abnormalities in temporomandibular joints (p < 0.05), and periodontal infections (p = 0.002) was observed in the study group compared to the control group. Conclusion: Orofacial pain and periodontal infections were more frequent in patients with mild AD than in healthy subjects. Orofacial pain screening and dental and oral exams should be routinely performed in AD patients in order to identify pathological conditions that need treatment thus improving quality of life compromised due to dementia.
dc.description.sponsorship · FAPESP (Foundation of Research of the State of Sao Paulo, Brazil) [2007/04930-1, 2007/06852-8, 2011/18756-9]
dc.language.iso eng
dc.publisher IOS PRESS
dc.relation.ispartof Journal of Alzheimers Disease
dc.rights restrictedAccess
dc.subject Alzheimer's disease; oral infections; orofacial pain; periodontitis; TMD
dc.subject.other mini-mental-state; cognitive impairment; tooth loss; health; inflammation; brain; dementia
dc.title Oral Infections and Orofacial Pain in Alzheimer's Disease: A Case-Control Study
dc.type article
dc.rights.holder Copyright IOS PRESS
dc.description.group LIM/26
dc.description.group LIM/15
dc.identifier.doi 10.3233/JAD-131283
dc.identifier.pmid 24077432
dc.type.category original article
dc.type.version publishedVersion
hcfmusp.author NITRINI, Ricardo:FM:MNE
hcfmusp.author ANGHINAH, Renato:FM:
hcfmusp.author TEIXEIRA, Manoel Jacobsen:FM:MNE
hcfmusp.author SIQUEIRA, Jose Tadeu T. de:HC:ICHC
hcfmusp.author CESTARI, Jose Augusto Ferrari:FM:
hcfmusp.author.external · ROLIM, Thais de Souza:Univ Sao Paulo, Sch Med, Orofacial Team, Hosp Clin, BR-05508 Sao Paulo, Brazil; Univ Sao Paulo, Sch Med, Dept Neurol, BR-05508 Sao Paulo, Brazil
· FABRI, Gisele Maria Campos:Univ Sao Paulo, Sch Med, Hosp Clin, Dent Div,Cent Inst, BR-05508 Sao Paulo, Brazil
· SIQUEIRA, Silvia Regina Dowgan T. de:Univ Sao Paulo, Sch Med, Hosp Clin, Grp Oral Med & Neurosci,Dent Div,Psychiat Inst, BR-05508 Sao Paulo, Brazil; Univ Sao Paulo, Sch Arts Sci & Humanities, BR-05508 Sao Paulo, Brazil
hcfmusp.origem.id WOS:000328335100011
hcfmusp.origem.id 2-s2.0-84890502432
hcfmusp.publisher.city AMSTERDAM
hcfmusp.publisher.country NETHERLANDS
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dc.description.index MEDLINE
dc.identifier.eissn 1875-8908
hcfmusp.citation.scopus 26
hcfmusp.citation.wos 22
hcfmusp.affiliation.country Brasil

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