Polymorphisms of estrogen receptor-alpha gene in Brazilian women with high breast density after menopause

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Citações na Scopus
3
Tipo de produção
article
Data de publicação
2013
Editora
INFORMA HEALTHCARE
DOI
Indexadores
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Autores
FRANZOLIN, Solange O. B.
SOARES- JR., Jose Maria
Autor de Grupo de pesquisa
Editores
Coordenadores
Organizadores
Citação
GYNECOLOGICAL ENDOCRINOLOGY, v.29, n.8, p.771-774, 2013
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
The association of genetic polymorphism in the estrogen receptor alpha (ER alpha) gene and risk for diseases including breast cancer (BC) has been the subject of great interest. Objective: Checking on women with high breast density after menopause, the frequency of the Pvull and Xbal polymorphisms of the ER alpha gene and the correlation between them and the known risk factors for breast cancer. Method: Observational study with 308 women between 45 and 65 years old with high breast density, without hormonal therapy, menstruation for a year or more, breast and ovarian cancer history. It was characterized in clinical history and physical examination: menarche, menopause, parity, family history of BC, smoking, alcohol intake and body mass index. Results: The allelic and genotypic frequencies for ER alpha-Pvull and Xbal: p = 43.99%; p = 56.01%; pp = 32.14%; Pp = 47.73% and PP = 20.13%; X = 41.56%; x = 58.44%; xx = 33.44%; Xx = 50.00% and XX = 16.56%, respectively. The most frequent risk factors for BC: menarche before 12 years old (35.38%), nulliparity or first child after 28 years old (41.66%), family history of BC (19.16%) and overweight/obesity (62.01%). Conclusion: Allelic and genotypic distribution similar to literature. The risk factors for BC were more prevalent in women with high breast density but without significant associations with these polymorphisms.
Palavras-chave
Breast neoplasms, estrogen receptors, genetic polymorphism, mammography, risk factors
URI
https://observatorio.fm.usp.br/handle/OPI/5418
Referências
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MOG
Artigos e Materiais de Revistas Científicas - FM/MDR
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - HC/InRad
Artigos e Materiais de Revistas Científicas - LIM/44
Artigos e Materiais de Revistas Científicas - LIM/58
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