The Liposuction-Induced Effects on Adiponectin and Selected Cytokines Are Not Affected by Exercise Training in Women

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.author SOLIS, Marina Yazigi FMUSP-HC
ARTIOLI, Guilherme Giannini
MONTAG, Eduardo FMUSP-HC
PAINELLI, Vitor de Salles
SAITO, Fabio Lopes
LIMA, Fernanda Rodrigues FMUSP-HC
ROSCHEL, Hamilton
GUALANO, Bruno FMUSP-HC
LANCHA JUNIOR, Antonio Herbert
BENATTI, Fabiana Braga FMUSP-HC
dc.date.issued 2014
dc.identifier.citation INTERNATIONAL JOURNAL OF ENDOCRINOLOGY, article ID 315382, 6p, 2014
dc.identifier.issn 1687-8337
dc.identifier.uri http://observatorio.fm.usp.br/handle/OPI/5513
dc.description.abstract It has been suggested that the abrupt liposuction-induced decrease in adipose tissue could affect adipokine secretion pattern. We hypothesized that exercise training could positively impact adipokine metabolism following liposuction. The aim of this study was to investigate the effects of liposuction on inflammation-related adipokines in women who were either exercise-trained or remained sedentary after surgery. Thirty-six healthy normal-weight women underwent an abdominal liposuction and two months after surgery were randomly allocated into two groups: trained (TR, n = 18, four-month exercise program) and nontrained (NT, n = 18). Inflammation-related adipokine serum levels (TNF-alpha, IL-6, IL-10, and adiponectin) and abdominal and thigh subcutaneous adipose tissue (scAT) mRNA levels were assessed before (PRE) and six months after surgery (POST6). TNF-alpha, IL-6, and IL-10 serum levels were unchanged in both groups. In contrast, TNF-alpha, IL-6, and IL-10 mRNA levels in scAT were increased, whereas adiponectin scAT mRNA and serum levels were decreased at POST6 (P < 0.05, main effect for time). No changes were observed in mRNA levels of MCP-1, CD14, and CD68 in any of the groups. In conclusion, liposuction downregulates adiponectin scAT gene expression and serum levels and upregulates scAT gene expression of inflammation-related genes six months after surgery in normal-weight women, irrespective of exercise training.
dc.description.sponsorship · FAPESP [2007/53319-3, 2011/08302-0, 2009/13985-0, 2013/04806-0, 2012/07319-0, 2007/53318-7]
· CNPq [308489/2010-1]
dc.language.iso eng
dc.publisher HINDAWI PUBLISHING CORPORATION
dc.relation.ispartof International Journal of Endocrinology
dc.rights openAccess
dc.subject.other large-volume liposuction; cardiovascular risk profile; subcutaneous adipose-tissue; coronary-heart-disease; obese women; insulin sensitivity; gene-expression; plasma-levels; resistance; fat
dc.title The Liposuction-Induced Effects on Adiponectin and Selected Cytokines Are Not Affected by Exercise Training in Women
dc.type article
dc.rights.holder Copyright HINDAWI PUBLISHING CORPORATION
dc.description.group LIM/04
dc.description.group LIM/17
dc.identifier.doi 10.1155/2014/315382
dc.identifier.pmid 24527033
dc.type.category original article
dc.type.version publishedVersion
hcfmusp.author SOLIS, Marina Yazigi:FM:
hcfmusp.author MONTAG, Eduardo:HC:LIM/04
hcfmusp.author LIMA, Fernanda Rodrigues:HC:LIM/17
hcfmusp.author GUALANO, Bruno:HC:LIM/17
hcfmusp.author BENATTI, Fabiana Braga:FM:
hcfmusp.author.external · ARTIOLI, Guilherme Giannini:Univ Sao Paulo, Sch Phys Educ & Sport, BR-05025010 Sao Paulo, Brazil
· PAINELLI, Vitor de Salles:Univ Sao Paulo, Sch Phys Educ & Sport, BR-05025010 Sao Paulo, Brazil
· SAITO, Fabio Lopes:Univ Sao Paulo, Sch Med, BR-05403000 Sao Paulo, Brazil
· ROSCHEL, Hamilton:Univ Sao Paulo, Sch Med, BR-05403000 Sao Paulo, Brazil; Univ Sao Paulo, Sch Phys Educ & Sport, BR-05025010 Sao Paulo, Brazil
· LANCHA JUNIOR, Antonio Herbert:Univ Sao Paulo, Sch Phys Educ & Sport, BR-05025010 Sao Paulo, Brazil
hcfmusp.origem.id 2-s2.0-84893164422
hcfmusp.origem.id WOS:000330390400001
hcfmusp.publisher.city NEW YORK
hcfmusp.publisher.country USA
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dc.description.index PubMed
dc.identifier.eissn 1687-8345
hcfmusp.citation.scopus 6
hcfmusp.citation.wos 6
hcfmusp.affiliation.country Brasil


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