Low RKIP expression associates with poor prognosis in bladder cancer patients

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.author AFONSO, Julieta
LONGATTO-FILHO, Adhemar FMUSP-HC
MARTINHO, Olga
LOBO, Francisco
AMARO, Teresina
REIS, Rui M.
SANTOS, Lucio L.
dc.date.issued 2013
dc.identifier.citation VIRCHOWS ARCHIV, v.462, n.4, p.445-453, 2013
dc.identifier.issn 0945-6317
dc.identifier.uri http://observatorio.fm.usp.br/handle/OPI/5519
dc.description.abstract Urothelial bladder cancer (UBC) is a heterogeneous type of disease. It is urgent to screen biomarkers of tumour aggressiveness in order to clarify the clinical behaviour and to personalize therapy in UBC patients. Raf kinase inhibitory protein (RKIP) is a metastasis suppressor, and its downregulation is associated with metastatic events in an increasing number of solid tumours. We evaluated the clinical and prognostic significance of RKIP expression in patients with high risk of progression UBC. Using immunohistochemistry, we determined RKIP expression levels in a series of 81 patients with high-grade pT1/pTis or muscle-invasive UBC. Staining of CD31 and D2-40 was used to assess blood and lymphatic vessels, in order to distinguish between blood and lymphatic vessel invasion (LVI). We found that 90 % of pT1/pTis tumours, 94 % of non-muscle invasive papillary tumours and 76 % of the cases without LVI occurrence expressed RKIP in > 10 % of cells. In this group, we observed a subgroup of tumours (42 %) in which the tumour centre was significantly more intensely stained than the invasion front. This heterogeneous pattern was observed in 63 % of the cases with LVI. Low RKIP expression was associated with poorer 5-year disease-free and overall survival rates, and remained as an independent prognostic factor for disease-free survival. Loss of RKIP expression may be an important prognostic factor for patients with high risk of progression bladder cancer.
dc.language.iso eng
dc.publisher SPRINGER
dc.relation.ispartof Virchows Archiv
dc.rights restrictedAccess
dc.subject Bladder cancer; Biomarkers; RKIP; Lymphovascular invasion; Prognosis
dc.subject.other kinase inhibitor protein; nf-kappa-b; squamous-cell carcinoma; prostate-cancer; breast-cancer; mesenchymal transition; braf gene; raf; metastasis; invasion
dc.title Low RKIP expression associates with poor prognosis in bladder cancer patients
dc.type article
dc.rights.holder Copyright SPRINGER
dc.description.group LIM/14
dc.identifier.doi 10.1007/s00428-013-1388-2
dc.identifier.pmid 23462986
dc.type.category original article
dc.type.version publishedVersion
hcfmusp.author LONGATTO-FILHO, Adhemar:HC:LIM/14
hcfmusp.author.external · AFONSO, Julieta:Univ Minho, Life & Hlth Sci Res Inst ICVS, Braga, Portugal; ICVS 3Bs PT Govt Associate Lab, Braga, Portugal
· MARTINHO, Olga:Univ Minho, Life & Hlth Sci Res Inst ICVS, Braga, Portugal; ICVS 3Bs PT Govt Associate Lab, Braga, Portugal
· LOBO, Francisco:Portuguese Inst Oncol IPO, Dept Urol, P-4200072 Oporto, Portugal
· AMARO, Teresina:Portuguese Inst Oncol IPO, Expt Pathol & Therapeut Res Ctr, P-4200072 Oporto, Portugal
· REIS, Rui M.:Univ Minho, Life & Hlth Sci Res Inst ICVS, Braga, Portugal; ICVS 3Bs PT Govt Associate Lab, Braga, Portugal; Barretos Canc Hosp, Mol Oncol Res Ctr, Sao Paulo, Brazil
· SANTOS, Lucio L.:Portuguese Inst Oncol IPO, Dept Surg Oncol, P-4200072 Oporto, Portugal; Univ Fernando Pessoa UFP, Oporto, Portugal
hcfmusp.origem.id WOS:000317856400009
hcfmusp.origem.id 2-s2.0-84876502122
hcfmusp.publisher.city NEW YORK
hcfmusp.publisher.country USA
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dc.description.index MEDLINE
hcfmusp.citation.scopus 9
hcfmusp.citation.wos 9
hcfmusp.affiliation.country Brasil
hcfmusp.affiliation.country Portugal


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