Preserving the B-Cell Compartment Favors Operational Tolerance in Human Renal Transplantation

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art_SILVA_Preserving_the_B_Cell_Compartment_Favors_Operational_Tolerance_2012.PDF (2.05 MB)
Citações na Scopus
77
Tipo de produção
article
Data de publicação
2012
Editora
FEINSTEIN INST MED RES
DOI
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Scopus
Web of Science
PubMed
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Autores
CHAARA, Wahiba
SIX, Adrien
AGENA, Fabiana
SESTERHEIM, Patricia
BARBE-TUANA, Florencia Maria
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Citação
MOLECULAR MEDICINE, v.18, n.5, p.733-743, 2012
Projetos de Pesquisa
Unidades Organizacionais
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Resumo
Transplanted individuals in operational tolerance (OT) maintain long-term stable graft function after completely stopping immunosuppression. Understanding the mechanisms involved in OT can provide valuable information about pathways to human transplantation tolerance. Here we report that operationally tolerant individuals display quantitative and functional preservation of the B-c ell compartment in renal transplantation. OT exhibited normal numbers of circulating total B cells, naive, memory and regulatory B cells (Bregs) as well as preserved B-cell receptor repertoire, similar to healthy individuals. In addition, OT also displayed conserved capacity to activate the cluster of differentiation 40 (CD40)/signal transducer and activator of transcription 3 (STAT3) signaling pathway in Bregs, in contrast, with chronic rejection. Rather than expansion or higher activation, we show that the preservation of the B-cell compartment favors OT. Online address: http://www.molmed.org doi: 10.2119/molmed.2011.00281
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URI
https://observatorio.fm.usp.br/handle/OPI/554
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MCM
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - LIM/19