Anti-trypanosomal Phenolic Derivatives from Baccharis uncinella

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.author GREECO, Simone dos S.
FELIX, Maria Julia P.
LAGO, Joao Henrique G.
PINTO, Erika G. FMUSP-HC
TEMPONE, Andre G.
ROMOFF, Paulete
FERREIRA, Marcelo Jose P.
SARTORELLI, Patricia
dc.date.issued 2014
dc.identifier.citation NATURAL PRODUCT COMMUNICATIONS, v.9, n.2, p.171-173, 2014
dc.identifier.issn 1934-578X
dc.identifier.uri http://observatorio.fm.usp.br/handle/OPI/5547
dc.description.abstract Bioassay-guided fractionation of the EtOH extract of the aerial parts of Baccharis uncinella C. DC. (Asteraceae) led to identification of two cinnamic acid derivatives (caffeic and ferulic acids), two flavones (hispidulin and pectolinaringenin) and a mixture of three chlorogenic acids (3,4-, 3,5- and 4,5-O-dicaffeoylquinic acids), which displayed in vitro anti-trypanosomal activity. Pectolinaringenin, hispidulin and caffeic acid showed activity against trypomastigotes of Trypanosoma cruzi, exhibiting 50% inhibitory concentration (IC50) values of 52, 81 and 56 mu g/mL, respectively, while the chlorogenic acid mixture showed an IC50 value of 61 mu g/mL. The flavonoids and cinnamic acid derivatives were evaluated for cytotoxicity against NCTC cells resulting in a 50% cytotoxic concentration (CC50) ranging from 33.82 to 129.1 mu g/mL while the chlorogenic acids did not display cytotoxicity (CC50 >150 mu g/mL). This is the first report of anti-trypanosomal activity of compounds from B. uncinella.
dc.description.sponsorship · FAPESP [2011/51739-0]
· CNPq [470853/2012-3]
dc.language.iso eng
dc.publisher NATURAL PRODUCTS INC
dc.relation.ispartof Natural Product Communications
dc.rights restrictedAccess
dc.subject Baccharis uncinella; Asteraceae; Antitrypanosomal; Flavanones; Chlorogenic acids; Cinnamic acid derivatives
dc.subject.other chagas-disease chemotherapy; retusa dc. asteraceae; aerial parts; metabolites; plants; drugs
dc.title Anti-trypanosomal Phenolic Derivatives from Baccharis uncinella
dc.type article
dc.rights.holder Copyright NATURAL PRODUCTS INC
dc.identifier.pmid 24689283
dc.type.category original article
dc.type.version publishedVersion
hcfmusp.author PINTO, Erika G.:IMT:
hcfmusp.author.external · GREECO, Simone dos S.:Univ Fed Sao Paulo, Inst Ciencias Ambientais Quim & Farmacet, BR-09972270 Diadema, SP, Brazil; Univ Fed ABC, Ctr Ciencias Nat & Humanas, BR-0909040 Santo Andre, SP, Brazil
· FELIX, Maria Julia P.:Univ Fed Sao Paulo, Inst Ciencias Ambientais Quim & Farmacet, BR-09972270 Diadema, SP, Brazil
· LAGO, Joao Henrique G.:Univ Fed Sao Paulo, Inst Ciencias Ambientais Quim & Farmacet, BR-09972270 Diadema, SP, Brazil
· TEMPONE, Andre G.:Univ Presbiteriana Mackenzie, Ctr Ciencias & Humanidades, BR-01302907 Sao Paulo, Brazil
· ROMOFF, Paulete:Univ Presbiteriana Mackenzie, Ctr Ciencias & Humanidades, BR-01302907 Sao Paulo, Brazil
· FERREIRA, Marcelo Jose P.:Univ Presbiteriana Mackenzie, Ctr Ciencias & Humanidades, BR-01302907 Sao Paulo, Brazil
· SARTORELLI, Patricia:Univ Fed Sao Paulo, Inst Ciencias Ambientais Quim & Farmacet, BR-09972270 Diadema, SP, Brazil
hcfmusp.origem.id WOS:000331666900010
hcfmusp.origem.id 2-s2.0-84894500959
hcfmusp.publisher.city WESTERVILLE
hcfmusp.publisher.country USA
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dc.description.index MEDLINE
dc.identifier.eissn 1555-9475
hcfmusp.citation.scopus 12
hcfmusp.citation.wos 11
hcfmusp.affiliation.country Brasil


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