Anti-trypanosomal Phenolic Derivatives from Baccharis uncinella

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Citações na Scopus
22
Tipo de produção
article
Data de publicação
2014
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
NATURAL PRODUCTS INC
Autores
GREECO, Simone dos S.
FELIX, Maria Julia P.
LAGO, Joao Henrique G.
TEMPONE, Andre G.
ROMOFF, Paulete
FERREIRA, Marcelo Jose P.
SARTORELLI, Patricia
Citação
NATURAL PRODUCT COMMUNICATIONS, v.9, n.2, p.171-173, 2014
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Bioassay-guided fractionation of the EtOH extract of the aerial parts of Baccharis uncinella C. DC. (Asteraceae) led to identification of two cinnamic acid derivatives (caffeic and ferulic acids), two flavones (hispidulin and pectolinaringenin) and a mixture of three chlorogenic acids (3,4-, 3,5- and 4,5-O-dicaffeoylquinic acids), which displayed in vitro anti-trypanosomal activity. Pectolinaringenin, hispidulin and caffeic acid showed activity against trypomastigotes of Trypanosoma cruzi, exhibiting 50% inhibitory concentration (IC50) values of 52, 81 and 56 mu g/mL, respectively, while the chlorogenic acid mixture showed an IC50 value of 61 mu g/mL. The flavonoids and cinnamic acid derivatives were evaluated for cytotoxicity against NCTC cells resulting in a 50% cytotoxic concentration (CC50) ranging from 33.82 to 129.1 mu g/mL while the chlorogenic acids did not display cytotoxicity (CC50 >150 mu g/mL). This is the first report of anti-trypanosomal activity of compounds from B. uncinella.
Palavras-chave
Baccharis uncinella, Asteraceae, Antitrypanosomal, Flavanones, Chlorogenic acids, Cinnamic acid derivatives
URI
https://observatorio.fm.usp.br/handle/OPI/5547
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Coleções
Artigos e Materiais de Revistas Científicas - IMT