Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/5553
Title: Influence of the intraperitoneal administration of antitumor Abarema auriculata extract on mice behavior
Authors: GUSMAO, Daniela F.ESTORK, Dirce M.PACIENCIA, Mateus L.B.DIAZ, Ingrit E.C.MONTERO, Edna F.S.VARELLA, Antonio DrauzioREIS, Luiz Fernando LimaYOUNES, Riad N.SUFFREDINI, Ivana B.BERNARDI, Maria M.
Citation: REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, v.23, n.6, p.903-912, 2013
Abstract: The organic extract EB689, obtained from the stem of Abarema auriculata (Benth.) Barneby & J.W.Grimes, Fabaceae, commonly known as ""saboeiro-ferro"", was chemically studied, as well as its influence over behavioral effects such as locomotion, emotionality and anxiety, after intra-peritonial administration were assessed. The open-field and elevated-plus maze were used in experiments divided into two stages. The first stage aimed for the identification of the main effects over behavior using a reduced number of animals against half-fold diluted doses of EB689. The same variables were also tested in a second stage of the experiment using the non-lethal intra-peritoneal dose of 4.8 mg/kg in a larger number of animals. It was observed that EB689 clearly decreased locomotion, which was probably caused by internal hemorrhage causing hypovolemic shock. Although it is the first time lupeol and eucryphin are described in A. auriculata, it is still not clear if they are involved in the toxicology of A. auriculata. The undesirable effects of EB689 are better understood, the basis for further pharmacological assays aiming antitumor activity are supported.
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Artigos e Materiais de Revistas Científicas - FM/MCG
Departamento de Cirurgia - FM/MCG

Artigos e Materiais de Revistas Científicas - LIM/62
LIM/62 - Laboratório de Fisiopatologia Cirúrgica


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