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https://observatorio.fm.usp.br/handle/OPI/720
Title: | The Differential Clinical Impact of Human Coronavirus Species in Children With Cystic Fibrosis |
Authors: | SILVA FILHO, Luiz Vicente Ribeiro Ferreira da; ZERBINATI, Rodrigo Melim; TATENO, Adriana Fumie; BOAS, Lucy Vilas; ALMEIDA, Marina Buarque de; LEVI, Jose Eduardo; DREXLER, Jan Felix; DROSTEN, Christian; PANNUTI, Claudio Sergio |
Citation: | JOURNAL OF INFECTIOUS DISEASES, v.206, n.3, p.384-388, 2012 |
Abstract: | We investigated the clinical impact of human coronaviruses (HCoV) OC43, 229E, HKU1 and NL63 in pediatric patients with cystic fibrosis (CF) during routine and exacerbation visits. A total of 408 nasopharyngeal aspirate samples were obtained from 103 patients over a 1-year period. Samples positive for HCoV were submitted for nucleotide sequencing to determine the species. Nineteen samples (4.65%) were positive for HCoV, of which 8 were positive for NL63, 6 for OC43, 4 for HKU1, and 1 for 229E. Identification of HCoV was not associated with an increased rate of respiratory exacerbations, but NL63-positive patients had higher exacerbation rates than patients who were positive for other HCoV species. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MIP Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - HC/ICr Artigos e Materiais de Revistas Científicas - HC/InCor Artigos e Materiais de Revistas Científicas - LIM/36 Artigos e Materiais de Revistas Científicas - LIM/52 |
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