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https://observatorio.fm.usp.br/handle/OPI/735
Title: | Evaluation of HIV-1 resistance to antiretroviral drugs among 150 patients after six months of therapeutic interruption |
Authors: | KALMAR, E. M. N.; SANABANI, S. S.; COSTA, A. Charlys da; FERREIRA, S.; BARRETO, C. C.; CHEN, S.; SABINO, E. C. |
Citation: | INTERNATIONAL JOURNAL OF STD & AIDS, v.23, n.2, p.120-125, 2012 |
Abstract: | Most of the antiretroviral (ARV) studies in Brazil have been reported in treatment-experienced and naive patients rather than in the setting of treatment interruption (TI). In this study, we analysed reasons given for TI and resistance mutations occurring in 150 HIV-1-infected patients who underwent TI. Of the patients analysed, 110 (73.3%) experienced TI following medical advice, while the remaining patients stopped antiretroviral therapy (ART) of their own accord. The main justifications for TI were: ARV-related toxicities (38.7%), good laboratory parameters (30%) and poor adherence (20%). DNA sequencing of the partial pol gene was successful in 137 (91.3%) patients, of whom 38 (27.7%) presented mutations conferring ARV resistance. A higher viral load prior to TI correlated with drug resistance (P < 0.05). Our results demonstrate that there are diverse rationales for TI and that detection of resistant strains during TI most likely indicates a fitter virus than the wild type. High viral loads coupled with unprotected sex in this group could increase the likelihood of transmission of drug-resistant virus. Thus, treating physicians should be alerted to this problem when the use of ARVs is interrupted. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MIP Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - LIM/52 |
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