Determinants of Arterial Stiffness in Female Patients with Takayasu Arteritis

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art_ROSA NETO_Determinants_of_Arterial_Stiffness_in_Female_Patients_with_2014.PDF (120.22 KB)
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14
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article
Data de publicação
2014
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J RHEUMATOL PUBL CO
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Scopus
Web of Science
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JOURNAL OF RHEUMATOLOGY, v.41, n.7, p.1374-1378, 2014
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Resumo
Objective. The assessment of pulse wave velocity (PWV) in Takayasu arteritis (TA) is complex because of many confounding factors. We evaluated PWV in female patients with TA and controls with comparable anthropometric and clinical variables and assessed a possible association of TA with disease variables. Methods. We evaluated 27 patients with TA consecutively. Exclusion criteria were menopause, smoking, diabetes, renal insufficiency, poorly controlled hypertension, cardiac arrhythmias, obesity, inflammatory comorbidities, pregnancy, and surgical procedures involving the aorta. Disease activity was determined by clinical and laboratory variables. As healthy controls, 27 subjects with comparable age, blood pressure, height, and weight were selected. Carotid-femoral PWV measurements were obtained using the Complior system. Results. The mean PWV in patients with TA was higher than in healthy controls (9.77 +/- 3.49 vs 7.83 +/- 1.06 m/s; p = 0.009). Despite our strict selection criteria, patients with TA had an average systolic blood pressure (SBP) 8 mmHg higher than controls (p = NS), and significantly higher pulse pressure values. The multivariate linear regression model shows that 93.8% of the PWV variability is explained by the variables age, mean BP, and the disease itself (adjusted R-2 = 0.938). Stepwise logistic analysis using the PWV cutoff value established by the receiver-operator characteristic curve (> 8.34 m/s) as dependent variable, and measures with significance in univariate analysis as independent variables revealed that TA (OR 4.69; 95% CI 1.31-16.72; p = 0.017) and mean BP (OR 1.06; 95% CI 1.00 - 1.12; p = 0.048) were independently associated with higher PWV. Further analysis of disease variables revealed that PWV values were not correlated with erythrocyte sedimentation rate, C-reactive protein, cumulative dose of glucocorticoid, or ejection fraction (p > 0.05). Conclusion. In our cohort of female patients with TA, the disease itself and mean BP were the strongest determinants associated with arterial stiffness.
Palavras-chave
ARTERIAL STIFFNESS, TAKAYASU ARTERITIS, PULSE WAVE VELOCITY, HYPERTENSION, ATHEROSCLEROSIS
URI
https://observatorio.fm.usp.br/handle/OPI/7389
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MCM
Artigos e Materiais de Revistas Científicas - HC/ICESP
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - LIM/17
Artigos e Materiais de Revistas Científicas - ODS/03