High prevalence of hepatitis B virus subgenotypes A1 and D4 in Maranhao state, Northeast Brazil

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.author BARROS, Lena Maria Fonseca
GOMES-GOUVEA, Michele Soares FMUSP-HC
KRAMVIS, Anna
MENDES-CORREA, Maria Cassia Jacintho FMUSP-HC
SANTOS, Alexsandro dos
SOUZA, Leticia Alana Barros
SANTOS, Max Diego Cruz
CARRILHO, Flair Jose FMUSP-HC
DOMICINI, Arnaldo de Jesus
PINHO, Joao Renato Rebello FMUSP-HC
FERREIRA, Adalgisa de Souza Paiva
dc.date.issued 2014
dc.identifier.citation INFECTION GENETICS AND EVOLUTION, v.24, p.68-75, 2014
dc.identifier.issn 1567-1348
dc.identifier.uri http://observatorio.fm.usp.br/handle/OPI/7519
dc.description.abstract In this study, we determined the prevalence of HBV subgenotypes in Maranhao state, located in northeastern Brazil, where the population is heterogeneous, with a high proportion of African descendants. HBV was detected in 119 of 133 (89.5%) chronic hepatitis B patients, including 103 (86.5%) who were HBeAg-negative. Using phylogenetic analysis of the S/Polymerase region of HBV DNA, subgenotype A1 was found to be the most prevalent (67%), followed by genotype D (28%; subgenotype D4 was detected in 24%, D3 in 3%, and D2 in 1%). Genotype F, clustering with subgenotype F2a, was found in six (5%) patients. The topology of the phylogenetic tree showed that HBV/A1 sequences did not cluster together, suggesting that more than one strain was introduced into Maranhao. On the other hand, HBV/D4 sequences formed a monophyletic cluster, suggesting a single entry of this strain in this population. This study showed that HBV/A1 was the only subgenotype of HBV/A present in the population from Maranhao and indicated that in this region HBV/A1 was not restricted to an Afro-descendant community where it was previously reported, but is widely distributed among general population of HBV chronic carriers. Unexpectedly, we found a high frequency of HBV subgenotype D4. Together with previously reported data on the distribution of HBV/D4 in the world, these findings suggest that this subgenotype was more prevalent in the African continent in the past and may have been introduced in Maranhao by means of the slave trade during the late XVIII century, when the largest number of African slaves arrived to this region.
dc.description.sponsorship · Sao Paulo Research Foundation (FAPESP) [2010/50081-9, 2010/51208-2]
· Fundacao de Amparo a Pesquisa do Estado do Maranhao - FAPEMA [APP2009/00950]
· Secretaria de Saude do Estado do Maranhao Departamento de Vigilancia Epidemiologica
dc.language.iso eng
dc.publisher ELSEVIER SCIENCE BV
dc.relation.ispartof Infection Genetics and Evolution
dc.rights restrictedAccess
dc.subject Phylogenetics; Subgenotype A1; Subgenotype D4; Slave trade; Maranhao; Brazil
dc.subject.other molecular characterization; genotype-f; genetic diversity; pregnant-women; hbv genotypes; infection; african; population; mutations; venezuela
dc.title High prevalence of hepatitis B virus subgenotypes A1 and D4 in Maranhao state, Northeast Brazil
dc.type article
dc.rights.holder Copyright ELSEVIER SCIENCE BV
dc.description.group LIM/07
dc.description.group LIM/06
dc.identifier.doi 10.1016/j.meegid.2014.03.007
dc.identifier.pmid 24642137
dc.type.category original article
dc.type.version publishedVersion
hcfmusp.author GOMES-GOUVEA, Michele Soares:FM:
hcfmusp.author MENDES-CORREA, Maria Cassia Jacintho:FM:MIP
hcfmusp.author CARRILHO, Flair Jose:FM:MGT
hcfmusp.author PINHO, Joao Renato Rebello:HC:LIM/07
hcfmusp.author.external · BARROS, Lena Maria Fonseca:Univ Fed Maranhao, Sao Luis, Maranhao, Brazil
· KRAMVIS, Anna:Univ Witwatersrand, Sch Clin Med, Dept Internal Med, Hepatitis Virus Div Res Programme, Johannesburg, South Africa
· SANTOS, Alexsandro dos:Univ Fed Maranhao, Sao Luis, Maranhao, Brazil
· SOUZA, Leticia Alana Barros:Univ Fed Maranhao, Sao Luis, Maranhao, Brazil
· SANTOS, Max Diego Cruz:Univ Fed Maranhao, Sao Luis, Maranhao, Brazil
· DOMICINI, Arnaldo de Jesus:Univ Fed Maranhao, Sao Luis, Maranhao, Brazil
· FERREIRA, Adalgisa de Souza Paiva:Univ Fed Maranhao, Sao Luis, Maranhao, Brazil
hcfmusp.origem.id 2-s2.0-84897442211
hcfmusp.origem.id WOS:000335376800007
hcfmusp.publisher.city AMSTERDAM
hcfmusp.publisher.country NETHERLANDS
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dc.description.index MEDLINE
dc.identifier.eissn 1567-7257
hcfmusp.citation.scopus 17
hcfmusp.citation.wos 17
hcfmusp.affiliation.country Brasil
hcfmusp.affiliation.country África do Sul


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